circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway

Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by clusters of cancer cells surrounded by a dense desmoplastic stroma. However, little is known about stromal cell heterogeneity in the pancreatic tumor microenvironment. Methods We conducted circRNA profiling in primary fibroblasts...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2022-02, Vol.41 (1)
Hauptverfasser:	Zheng, Shangyou, Hu, Chonghui, Lin, Hongcao, Li, Guolin, Xia, Renpeng, Zhang, Xiang, Su, Dan, Li, Zhihua, Zhou, Quanbo, Chen, Rufu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Analysis Development and progression Enzyme-linked immunosorbent assay Genetic aspects Pancreatic cancer RNA
Online-Zugang:	Volltext
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