Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusion Injury

The interleukins (ILs) are a pluripotent cytokine family that have been reported to regulate ischemic stroke and cerebral ischemia/reperfusion (I/R) injury. IL-22 is a member of the IL-10 superfamily and plays important roles in tissue injury and repair. However, the effects of IL-22 on ischemic str...

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Veröffentlicht in:	Mediators of inflammation 2021, Vol.2021, p.6621296-14, Article 6621296
Hauptverfasser:	Dong, Yongfei, Hu, Chengyun, Huang, Chunxia, Gao, Jie, Niu, Wanxiang, Wang, Di, Wang, Yang, Niu, Chaoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brain Brain Ischemia - metabolism Brain research Cell Biology Cerebral cortex Cytokines IL-1β Immunology Inflammation Infrared imaging systems Interleukin 10 Interleukin 22 Interleukins Interleukins - metabolism Interleukins - pharmacology Ischemia Janus kinase 2 Janus Kinase 2 - metabolism Laboratory animals Life Sciences & Biomedicine Mice Monocytes Neurological diseases Neurons Neuroprotection Oxidative Stress Pheochromocytoma cells Phosphorylation Pluripotency Protein-tyrosine kinase Proteins Rats Reperfusion Reperfusion Injury - metabolism Science & Technology Signal Transduction Stat3 protein STAT3 Transcription Factor - metabolism Stroke Transcription Traumatic brain injury Tumor necrosis factor Tumor necrosis factor-TNF Variance analysis Water content
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