Endothelial Piezol sustains muscle capillary density and contributes to physical activity

Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell-specific deletion of Piezo1 in adult mice depressed physical performance. Muscle...

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Veröffentlicht in:	The Journal of clinical investigation 2022-03, Vol.132 (5)
Hauptverfasser:	Bartoli, Fiona, Debant, Marjolaine, Chuntharpursat-Bon, Eulashini, Evans, Elizabeth L, Musialowski, Katie E, Parsonage, Gregory, Morley, Lara C, Futers, T. Simon, Sukumar, Piruthivi, Bowen, T. Scott, Kearney, Mark T, Lichtenstein, Laeticia, Roberts, Lee D, Beech, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Capillaries Endothelium Exercise Membrane proteins Physiological aspects Physiological research
Online-Zugang:	Volltext
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