Lung Cancer-Targeted [131I]-Iodoshikonin as Theranostic Agent: Radiolabeling, In Vivo Pharmacokinetics and Biodistribution
Shikonin has been reported to exhibit high affinity toward lung cells and recited to inhibit the migration and invasion of lung cancer cells and suppress their growth. Shikonin cause noteworthy potential cytotoxic actions against A-549 lung cancer cells with IC 50 ≈ 3.5 μg/L per 10 4 cells. 131 I-sh...
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Veröffentlicht in: | Pharmaceutical chemistry journal 2022-02, Vol.55 (11), p.1163-1168 |
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creator | Selim, Adli A. Motaleb, M. A. Fayez, Hend A. |
description | Shikonin has been reported to exhibit high affinity toward lung cells and recited to inhibit the migration and invasion of lung cancer cells and suppress their growth. Shikonin cause noteworthy potential cytotoxic actions against A-549 lung cancer cells with IC
50
≈ 3.5 μg/L per 10
4
cells.
131
I-shikonin was created with a high radiochemical yield of 92 ± 2.5% under the optimized conditions.
In vivo
pharmacokinetic and biodistribution studies of the new labeled shikonin showed high lung uptake reaching 81.28 ± 2% injected dose per gram at 15 min post injection with a high lung/heart and lung/blood ratios. The newly synthesized [
131
I]-iodoshikonin affords potential lung theranostic radiopharmaceutical. In conclusion, the results showed the potential use of [
131
I]-iodoshikonin as a promising system for lung imaging. |
doi_str_mv | 10.1007/s11094-022-02553-x |
format | Article |
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50
≈ 3.5 μg/L per 10
4
cells.
131
I-shikonin was created with a high radiochemical yield of 92 ± 2.5% under the optimized conditions.
In vivo
pharmacokinetic and biodistribution studies of the new labeled shikonin showed high lung uptake reaching 81.28 ± 2% injected dose per gram at 15 min post injection with a high lung/heart and lung/blood ratios. The newly synthesized [
131
I]-iodoshikonin affords potential lung theranostic radiopharmaceutical. In conclusion, the results showed the potential use of [
131
I]-iodoshikonin as a promising system for lung imaging.</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-022-02553-x</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Fenoterol ; Lung cancer ; Medicine ; Nuclear energy ; Organic Chemistry ; Pharmacology/Toxicology ; Pharmacy</subject><ispartof>Pharmaceutical chemistry journal, 2022-02, Vol.55 (11), p.1163-1168</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-4da5798e3af0bd18b2ef47f08ecb50aed8fb43b0b03bc0df7ca4fb7d93a313873</citedby><cites>FETCH-LOGICAL-c358t-4da5798e3af0bd18b2ef47f08ecb50aed8fb43b0b03bc0df7ca4fb7d93a313873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11094-022-02553-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11094-022-02553-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Selim, Adli A.</creatorcontrib><creatorcontrib>Motaleb, M. A.</creatorcontrib><creatorcontrib>Fayez, Hend A.</creatorcontrib><title>Lung Cancer-Targeted [131I]-Iodoshikonin as Theranostic Agent: Radiolabeling, In Vivo Pharmacokinetics and Biodistribution</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><description>Shikonin has been reported to exhibit high affinity toward lung cells and recited to inhibit the migration and invasion of lung cancer cells and suppress their growth. Shikonin cause noteworthy potential cytotoxic actions against A-549 lung cancer cells with IC
50
≈ 3.5 μg/L per 10
4
cells.
131
I-shikonin was created with a high radiochemical yield of 92 ± 2.5% under the optimized conditions.
In vivo
pharmacokinetic and biodistribution studies of the new labeled shikonin showed high lung uptake reaching 81.28 ± 2% injected dose per gram at 15 min post injection with a high lung/heart and lung/blood ratios. The newly synthesized [
131
I]-iodoshikonin affords potential lung theranostic radiopharmaceutical. In conclusion, the results showed the potential use of [
131
I]-iodoshikonin as a promising system for lung imaging.</description><subject>Fenoterol</subject><subject>Lung cancer</subject><subject>Medicine</subject><subject>Nuclear energy</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kW9rFDEQh4MoeLZ-AV8FfNvUyWbT3fXdeWg9OLDItQgiYfJvL-1dIsleqf30TT3fFIoMw8DwewaGh5B3HE45QPehcA5Dy6Bpaksp2N0LMuOyE2wAwV-SGcDAGZfw4zV5U8o1QMVEMyP3q30c6QKjcZmtMY9ucpb-5IIvf7Flsqlswk2KIVIsdL1xGWMqUzB0Pro4faTf0Ya0Re22IY4ndBnpVbhN9GKDeYcm3YToarpQjJZ-CsmGMuWg91NI8Zi88rgt7u2_eUQuv3xeL76y1bfz5WK-YkbIfmKtRdkNvRPoQVve68b5tvPQO6MloLO9163QoEFoA9Z3BluvOzsIFFz0nTgi7w93R9w6FaJPU0azC8Wo-dkgWym6M15Tp8-kalm3CyZF50PdPwGaA2ByKiU7r37nsMP8R3FQj1LUQYqqUtRfKequQuIAlRqOo8vqOu1zrO__j3oAMvGRLA</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Selim, Adli A.</creator><creator>Motaleb, M. A.</creator><creator>Fayez, Hend A.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220201</creationdate><title>Lung Cancer-Targeted [131I]-Iodoshikonin as Theranostic Agent: Radiolabeling, In Vivo Pharmacokinetics and Biodistribution</title><author>Selim, Adli A. ; Motaleb, M. A. ; Fayez, Hend A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-4da5798e3af0bd18b2ef47f08ecb50aed8fb43b0b03bc0df7ca4fb7d93a313873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Fenoterol</topic><topic>Lung cancer</topic><topic>Medicine</topic><topic>Nuclear energy</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selim, Adli A.</creatorcontrib><creatorcontrib>Motaleb, M. A.</creatorcontrib><creatorcontrib>Fayez, Hend A.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selim, Adli A.</au><au>Motaleb, M. A.</au><au>Fayez, Hend A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung Cancer-Targeted [131I]-Iodoshikonin as Theranostic Agent: Radiolabeling, In Vivo Pharmacokinetics and Biodistribution</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2022-02-01</date><risdate>2022</risdate><volume>55</volume><issue>11</issue><spage>1163</spage><epage>1168</epage><pages>1163-1168</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>Shikonin has been reported to exhibit high affinity toward lung cells and recited to inhibit the migration and invasion of lung cancer cells and suppress their growth. Shikonin cause noteworthy potential cytotoxic actions against A-549 lung cancer cells with IC
50
≈ 3.5 μg/L per 10
4
cells.
131
I-shikonin was created with a high radiochemical yield of 92 ± 2.5% under the optimized conditions.
In vivo
pharmacokinetic and biodistribution studies of the new labeled shikonin showed high lung uptake reaching 81.28 ± 2% injected dose per gram at 15 min post injection with a high lung/heart and lung/blood ratios. The newly synthesized [
131
I]-iodoshikonin affords potential lung theranostic radiopharmaceutical. In conclusion, the results showed the potential use of [
131
I]-iodoshikonin as a promising system for lung imaging.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-022-02553-x</doi><tpages>6</tpages></addata></record> |
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subjects | Fenoterol Lung cancer Medicine Nuclear energy Organic Chemistry Pharmacology/Toxicology Pharmacy |
title | Lung Cancer-Targeted [131I]-Iodoshikonin as Theranostic Agent: Radiolabeling, In Vivo Pharmacokinetics and Biodistribution |
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