Biologic TNF-[alpha] inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

Background Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a central role in Alzheimer's disease (AD) pathology, making biologic TNF-[alpha] inhibitors (TNFIs), including etanercept, viable therapeutics for AD. The protective effects of biologic TNFIs on AD hallmark pathology (A[beta] deposit...

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Veröffentlicht in:	Journal of neuroinflammation 2021-12, Vol.18 (1)
Hauptverfasser:	Ou, Weijun, Yang, Joshua, Simanauskaite, Juste, Choi, Matthew, Castellanos, Demi M, Chang, Rudy, Sun, Jiahong, Jagadeesan, Nataraj, Parfitt, Karen D, Cribbs, David H, Sumbria, Rachita K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Care and treatment Causes of Tau proteins Tumor necrosis factor
Online-Zugang:	Volltext
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