Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives
A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of couma...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2022, Vol.55 (10), p.1040-1049 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Radwan, Eman M. Elsayed, Elsherbiny H. El-Moneim, Mohamed Abd Youssef Moustafa, Amal M. |
| description | A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of coumarin derivatives with 2-hydroxybenzaldehyde yielded the corresponding acetyl derivatives and 4-substituted pyrazole derivatives. Structures of the synthesized compounds were elucidated by spectral methods and elemental analysis. All the prepared derivatives were evaluated for their cytotoxicity against human breast carcinoma cell line (MCF-7). Compound
VI
showed the least IC
50
value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin. |
| doi_str_mv | 10.1007/s11094-021-02535-5 |
| format | Article |
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VI
showed the least IC
50
value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin.</description><identifier>ISSN: 0091-150X</identifier><identifier>EISSN: 1573-9031</identifier><identifier>DOI: 10.1007/s11094-021-02535-5</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acylation ; Breast cancer ; Cancer ; Carcinoma ; Coumarins ; Diagnosis ; Medicine ; Organic Chemistry ; Pharmacology/Toxicology ; Pharmacy ; Phenylbutazone ; Resveratrol</subject><ispartof>Pharmaceutical chemistry journal, 2022, Vol.55 (10), p.1040-1049</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-8bb99c3ef70a24f85fe7ad1fdab0185e6965083c3d65d74dfdc17e5bd94383533</citedby><cites>FETCH-LOGICAL-c358t-8bb99c3ef70a24f85fe7ad1fdab0185e6965083c3d65d74dfdc17e5bd94383533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11094-021-02535-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11094-021-02535-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Radwan, Eman M.</creatorcontrib><creatorcontrib>Elsayed, Elsherbiny H.</creatorcontrib><creatorcontrib>El-Moneim, Mohamed Abd</creatorcontrib><creatorcontrib>Youssef Moustafa, Amal M.</creatorcontrib><title>Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives</title><title>Pharmaceutical chemistry journal</title><addtitle>Pharm Chem J</addtitle><description>A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of coumarin derivatives with 2-hydroxybenzaldehyde yielded the corresponding acetyl derivatives and 4-substituted pyrazole derivatives. Structures of the synthesized compounds were elucidated by spectral methods and elemental analysis. All the prepared derivatives were evaluated for their cytotoxicity against human breast carcinoma cell line (MCF-7). Compound
VI
showed the least IC
50
value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin.</description><subject>Acylation</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Coumarins</subject><subject>Diagnosis</subject><subject>Medicine</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phenylbutazone</subject><subject>Resveratrol</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rGzEQxUVJIY7bL9CTINdsIq1W--forN0mYNpDWuhNaKWRq7ArBUnrxNAPXyXOpRDCMAwzvN-D4SH0hZJLSkhzFSklXVWQkubmjBf8A1pQ3rCiI4yeoAUhHS0oJ79P0VmM94RkjJUL9Pfu4NIfiDZi6TTuD8kn_2SVTQe82knrYsI38yQdvg4g89LLoKzzk8Q9jCPe7OU4y2S9w97gOz8B_g6PmF1UxdrGeYjJpjlBdvbZJViH1xDsPhN7iJ_QRyPHCJ9f5xL9-rr52d8U2x_fbvvVtlCMt6loh6HrFAPTEFlWpuUGGqmp0XIgtOVQdzUnLVNM11w3lTZa0Qb4oLuKtYwztkTnR9-dHEFYZ3wKUk02KrGqu7Ku66Zus-ryDVUuDZNV3oGx-f4fUB4BFXyMAYx4CDY_eRCUiOdYxDEWkWMRL7EIniF2hGIWux0Ece_n4PL771H_AEKokNg</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Radwan, Eman M.</creator><creator>Elsayed, Elsherbiny H.</creator><creator>El-Moneim, Mohamed Abd</creator><creator>Youssef Moustafa, Amal M.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2022</creationdate><title>Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives</title><author>Radwan, Eman M. ; Elsayed, Elsherbiny H. ; El-Moneim, Mohamed Abd ; Youssef Moustafa, Amal M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-8bb99c3ef70a24f85fe7ad1fdab0185e6965083c3d65d74dfdc17e5bd94383533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acylation</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Coumarins</topic><topic>Diagnosis</topic><topic>Medicine</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phenylbutazone</topic><topic>Resveratrol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radwan, Eman M.</creatorcontrib><creatorcontrib>Elsayed, Elsherbiny H.</creatorcontrib><creatorcontrib>El-Moneim, Mohamed Abd</creatorcontrib><creatorcontrib>Youssef Moustafa, Amal M.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radwan, Eman M.</au><au>Elsayed, Elsherbiny H.</au><au>El-Moneim, Mohamed Abd</au><au>Youssef Moustafa, Amal M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2022</date><risdate>2022</risdate><volume>55</volume><issue>10</issue><spage>1040</spage><epage>1049</epage><pages>1040-1049</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with pyrazole-3,5-dione and condensation of ethyl 7-hydroxycoumarin-3-carboxylate with 4,6-dibromo-3-amino phenol. Acylation with acetic anhydride and condensation of coumarin derivatives with 2-hydroxybenzaldehyde yielded the corresponding acetyl derivatives and 4-substituted pyrazole derivatives. Structures of the synthesized compounds were elucidated by spectral methods and elemental analysis. All the prepared derivatives were evaluated for their cytotoxicity against human breast carcinoma cell line (MCF-7). Compound
VI
showed the least IC
50
value in MTT colorimetric assay as compared to that of the standard marketed drug staurosporin.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-021-02535-5</doi><tpages>10</tpages></addata></record> |
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| subjects | Acylation Breast cancer Cancer Carcinoma Coumarins Diagnosis Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Phenylbutazone Resveratrol |
| title | Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives |
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