Changes in the lipid profile of neutered cats' blood in cases of obesity and diabetes/Promjene lipidnog profila krvi steriliziranih pretilih macaka s dijabetesom

The aim of the present study was to examine the lipid profile, lipid fractions and the lipid peroxidation state in the blood of neutered cats with obesity and diabetes. Three groups of neutered cats (males and females) were formed for the study. We compared cats with obesity (7-9 points on a 9-point BCS scale), with obesity complicated by diabetes, and clinically healthy animals with normal body condition scores (4-5 BCS points). Lipidogram parameters, fractions of high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), chylomicrons (CM), lipid peroxidation products (POL) - lipid hydroperoxides (GPL) and malondialdehyde (MDA) were analysed. In obese cats, a decrease in HDL and phospholipids was observed, and an increase in LDL, VLDL, CM, triglycerides, and cholesterol. No significant differences in lipid and lipoprotein metabolism between neutered females and males were found. A tendency towards increasing concentrations of lipoproteins, triglycerides and cholesterol in males, as well as an increase in phospholipids in females was found. In cats with obesity and associated diabetes, the ratio of phospholipids: cholesterol was less than one, while in healthy cats - more than one. Obesity and diabetes initiate POL and increased concentrations of GPL and MDA, which were the highest in the blood of females with associated pathology. Key words: cat; obesity; triglycerides; cholesterol; phospholipids; lipid hydroperoxides Cilj ovog rada bio je istraziti lipidni profil, lipidne frakcije i lipidnu peroksidaciju u krvi ster-iliziranih pretilih macaka s dijabetesom. Za istrazivanje formirane su tri skupine steriliziranih macaka (muzjaka i zenki). Usporedene su pretile macke (7 - 9 bodova na BCS ljestvici od 9 bodova) s onima u kojih je pretilost komplicirana dijabetesom te klinicki zdravim zivotinjama s normalnim tjelesnim pokazateljima (4 - 5 BCS bodova). Analiziran je lipidogram, frakcije lipopro-teina visoke gustoce (HDL), lipoproteina niske gustoce (LDL) i lipoproteina vrlo niske gustoce (VLDL), kilomikroni (CM), produkti lipidne peroksidacije (POL) - lipidna hidroperoksidaza (GPL) i malondialdehid (MDA). U pretilih je macaka uocen snizen HDL i fosfolipidi te povisen LDL, VLDL, CM, trigliceridi i kolesterol. Nije bilo znakovite razlike u metabolizmu lipida i lipo-proteina izmedu kastriranih zenki i muzjaka. Uocena je sklonost porastu koncentracije lipopro-teina, triglicerida i kolesterola u muzjaka kao i porast fosf