FACTORS PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER/LOKAL ILERI MIDE KANSERINDE NEOADJUVAN KEMOTERAPIYE YANITI ONGOREN FAKTORLER
Objective: In the treatment of local advanced gastric cancer (LAGC), it is recommended to start with neoadjuvant chemotherapy (NAC). Although the benefits of NAC have been shown, it is still not fully understood which patients respond better. The aim of this study was to investigate the effect of he...
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| creator | Yildirim, Emine Bektas, Sibel Aydin, Sabin Goktas Er, Ahmet Muzaffer Yanik, Irem Gumuskaya, Perihan Ozkan Yilmaz, Barbaros Utku Bilici, Ahmet Oncel, Mustafa |
| description | Objective: In the treatment of local advanced gastric cancer (LAGC), it is recommended to start with neoadjuvant chemotherapy (NAC). Although the benefits of NAC have been shown, it is still not fully understood which patients respond better. The aim of this study was to investigate the effect of hematological and histopathological parameters on the response to chemotherapy. Materials and Methods: A retrospective examination was made of 38 patients who underwent surgery for LAGC after receiving NAC. Evaluations were made by comparing the demographic characteristics, histopathological characteristics in an endoscopic biopsy of the tumor, preoperative hemoglobin levels, and neutrophil-lymphocyte ratios with the postoperative pathological response to determine which tumor characteristics gave a better response. Results: In the postoperative histopathological evaluation, there was a pathological complete response to chemotherapy in two patients (6%), grade 1 in 9 patients (24%), grade 2 in 13 patients (34%), and grade 3 in 14 patients (36%). A statistically significant relationship was determined between the histopathological absence of perineural invasion and pathological complete response (p=0.023). Conclusion: A relationship between perineural invasion and poor response to chemotherapy was determined. Although not at a statistically significant level, there was also observed to be a poor response to chemotherapy in the presence of low grade and lymphovascular invasion. Keywords: Local advanced gastric cancer, neoadjuvant chemotherapy response, pathological complete response, perineural invasion Amac: Lokal ileri mide kanserinde (LIMK) tedaviye neoadjuvan kemoterapi (NAK) ile baslanmasi onerilir. Ancak NAK'nin faydalari gosterilmis olsa da hangi hasta gurubunun tedaviye daha iyi yanit verdigi tam olarak anlasilamamistir. Calismamizda hematolojik ve histopatolojik parametrelerin kemoterapi yaniti uzerine etkisi arastirilmistir. Yontem ve Gerec: Bu calismada lokal ileri evre mide kanseri nedeni ile neoadjuvan kemoterapi gorup sonrasinda ameliyat edilen 38 hasta retrospektif olarak incelendi. Ameliyat sonrasi patolojik yanit ile hastanin demografik ozellikleri, tumorun endoskopik biyopsideki histopatolojik ozellikleri, preoperatif hemoglobin seviyesi, notrofil lenfosit orani karsilastirilip hangi ozellikteki tumorlerin daha iyi yanit verdigi degerlendirildi. Bulgular: Ameliyat sonrasi yapilan histopatolojik degerlendirmede 2 (%6) hastada patolojik tam yanit, 9 |
| doi_str_mv | 10.26650/IUITFD.950751 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A691769365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A691769365</galeid><sourcerecordid>A691769365</sourcerecordid><originalsourceid>FETCH-LOGICAL-g675-30e6d870d96a28aca2a9902dc63f663307b80d4d3b9f1602c1db12cec7d317953</originalsourceid><addsrcrecordid>eNptjjtrwzAUhTW00JBm7XyhsxPJiuVoFLbsqHakICsFT8HxI7jkAU3_U_9mbVpoh3KH-zrn4yD0RPDcZyzAC7VTLonnPMBhQO7QhFAceGxJ6QOa3W5vGGM_ICTAywn6TETkjC1ga2WsIqd0ClYWW6MLCc6AlkbEL7tXoR1Ea7kxbi2t2JagNOQmEnlegoiHdyRjSEXhrIogGle7yE0mclC5tAo2KpaQiYFqlR7GXy5kI3WEqlJCKbRyCoxOjZUaEpEN6QbCI7rvqtOtnf30KXKJdNHay02qhhjekYWBR3HLmlWIG84qf1XVlV9xjv2mZrRjjFIcHla4WTb0wDvCsF-T5kD8uq3DhpKQB3SKnr-xx-rU7vtLd_14r-pzf6v3gnESMk7ZqJr_oxqqac99fb20XT_c_xi-AJAkbww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>FACTORS PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER/LOKAL ILERI MIDE KANSERINDE NEOADJUVAN KEMOTERAPIYE YANITI ONGOREN FAKTORLER</title><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>Yildirim, Emine ; Bektas, Sibel ; Aydin, Sabin Goktas ; Er, Ahmet Muzaffer ; Yanik, Irem ; Gumuskaya, Perihan Ozkan ; Yilmaz, Barbaros Utku ; Bilici, Ahmet ; Oncel, Mustafa</creator><creatorcontrib>Yildirim, Emine ; Bektas, Sibel ; Aydin, Sabin Goktas ; Er, Ahmet Muzaffer ; Yanik, Irem ; Gumuskaya, Perihan Ozkan ; Yilmaz, Barbaros Utku ; Bilici, Ahmet ; Oncel, Mustafa</creatorcontrib><description>Objective: In the treatment of local advanced gastric cancer (LAGC), it is recommended to start with neoadjuvant chemotherapy (NAC). Although the benefits of NAC have been shown, it is still not fully understood which patients respond better. The aim of this study was to investigate the effect of hematological and histopathological parameters on the response to chemotherapy. Materials and Methods: A retrospective examination was made of 38 patients who underwent surgery for LAGC after receiving NAC. Evaluations were made by comparing the demographic characteristics, histopathological characteristics in an endoscopic biopsy of the tumor, preoperative hemoglobin levels, and neutrophil-lymphocyte ratios with the postoperative pathological response to determine which tumor characteristics gave a better response. Results: In the postoperative histopathological evaluation, there was a pathological complete response to chemotherapy in two patients (6%), grade 1 in 9 patients (24%), grade 2 in 13 patients (34%), and grade 3 in 14 patients (36%). A statistically significant relationship was determined between the histopathological absence of perineural invasion and pathological complete response (p=0.023). Conclusion: A relationship between perineural invasion and poor response to chemotherapy was determined. Although not at a statistically significant level, there was also observed to be a poor response to chemotherapy in the presence of low grade and lymphovascular invasion. Keywords: Local advanced gastric cancer, neoadjuvant chemotherapy response, pathological complete response, perineural invasion Amac: Lokal ileri mide kanserinde (LIMK) tedaviye neoadjuvan kemoterapi (NAK) ile baslanmasi onerilir. Ancak NAK'nin faydalari gosterilmis olsa da hangi hasta gurubunun tedaviye daha iyi yanit verdigi tam olarak anlasilamamistir. Calismamizda hematolojik ve histopatolojik parametrelerin kemoterapi yaniti uzerine etkisi arastirilmistir. Yontem ve Gerec: Bu calismada lokal ileri evre mide kanseri nedeni ile neoadjuvan kemoterapi gorup sonrasinda ameliyat edilen 38 hasta retrospektif olarak incelendi. Ameliyat sonrasi patolojik yanit ile hastanin demografik ozellikleri, tumorun endoskopik biyopsideki histopatolojik ozellikleri, preoperatif hemoglobin seviyesi, notrofil lenfosit orani karsilastirilip hangi ozellikteki tumorlerin daha iyi yanit verdigi degerlendirildi. Bulgular: Ameliyat sonrasi yapilan histopatolojik degerlendirmede 2 (%6) hastada patolojik tam yanit, 9 (%24) hastada grade 1 yanit, 13 (%34) hastada grade 2 yanit ve 14 hastada (%36) grade 3 yanit mevcuttu. Patolojik tam yanit ile histopatolojik olarak perinoral invazyon olmamasi istatistiksel olarak anlamli iliski gosterdi (p=0,023). Sonuc: Calismamizda NAK alan LIMK'li hastalarda perinoral invazyon varliginin kemoterapiye kotu yanit ile iliskisi oldugu gorulmustur. Ayrica lenfovaskular invazyon ve dusuk grade mevcudiyetinde istatistiksel olarak anlamli olmasa da kemoterapiye kotu yanit gozlenmistir. Anahtar Kelimeler: Lokal ileri mide kanseri, neoadjuvan kemoterapi yaniti, patolojik tam yanit, perinoral invazyon</description><identifier>ISSN: 1305-6433</identifier><identifier>DOI: 10.26650/IUITFD.950751</identifier><language>eng</language><publisher>AVES</publisher><subject>Analysis ; Care and treatment ; Diagnosis ; Glycosylated hemoglobin ; Neoadjuvant therapy ; Patient outcomes ; Risk factors ; Stomach cancer</subject><ispartof>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine, 2022-03, Vol.85 (1), p.41</ispartof><rights>COPYRIGHT 2022 AVES</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids></links><search><creatorcontrib>Yildirim, Emine</creatorcontrib><creatorcontrib>Bektas, Sibel</creatorcontrib><creatorcontrib>Aydin, Sabin Goktas</creatorcontrib><creatorcontrib>Er, Ahmet Muzaffer</creatorcontrib><creatorcontrib>Yanik, Irem</creatorcontrib><creatorcontrib>Gumuskaya, Perihan Ozkan</creatorcontrib><creatorcontrib>Yilmaz, Barbaros Utku</creatorcontrib><creatorcontrib>Bilici, Ahmet</creatorcontrib><creatorcontrib>Oncel, Mustafa</creatorcontrib><title>FACTORS PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER/LOKAL ILERI MIDE KANSERINDE NEOADJUVAN KEMOTERAPIYE YANITI ONGOREN FAKTORLER</title><title>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine</title><description>Objective: In the treatment of local advanced gastric cancer (LAGC), it is recommended to start with neoadjuvant chemotherapy (NAC). Although the benefits of NAC have been shown, it is still not fully understood which patients respond better. The aim of this study was to investigate the effect of hematological and histopathological parameters on the response to chemotherapy. Materials and Methods: A retrospective examination was made of 38 patients who underwent surgery for LAGC after receiving NAC. Evaluations were made by comparing the demographic characteristics, histopathological characteristics in an endoscopic biopsy of the tumor, preoperative hemoglobin levels, and neutrophil-lymphocyte ratios with the postoperative pathological response to determine which tumor characteristics gave a better response. Results: In the postoperative histopathological evaluation, there was a pathological complete response to chemotherapy in two patients (6%), grade 1 in 9 patients (24%), grade 2 in 13 patients (34%), and grade 3 in 14 patients (36%). A statistically significant relationship was determined between the histopathological absence of perineural invasion and pathological complete response (p=0.023). Conclusion: A relationship between perineural invasion and poor response to chemotherapy was determined. Although not at a statistically significant level, there was also observed to be a poor response to chemotherapy in the presence of low grade and lymphovascular invasion. Keywords: Local advanced gastric cancer, neoadjuvant chemotherapy response, pathological complete response, perineural invasion Amac: Lokal ileri mide kanserinde (LIMK) tedaviye neoadjuvan kemoterapi (NAK) ile baslanmasi onerilir. Ancak NAK'nin faydalari gosterilmis olsa da hangi hasta gurubunun tedaviye daha iyi yanit verdigi tam olarak anlasilamamistir. Calismamizda hematolojik ve histopatolojik parametrelerin kemoterapi yaniti uzerine etkisi arastirilmistir. Yontem ve Gerec: Bu calismada lokal ileri evre mide kanseri nedeni ile neoadjuvan kemoterapi gorup sonrasinda ameliyat edilen 38 hasta retrospektif olarak incelendi. Ameliyat sonrasi patolojik yanit ile hastanin demografik ozellikleri, tumorun endoskopik biyopsideki histopatolojik ozellikleri, preoperatif hemoglobin seviyesi, notrofil lenfosit orani karsilastirilip hangi ozellikteki tumorlerin daha iyi yanit verdigi degerlendirildi. Bulgular: Ameliyat sonrasi yapilan histopatolojik degerlendirmede 2 (%6) hastada patolojik tam yanit, 9 (%24) hastada grade 1 yanit, 13 (%34) hastada grade 2 yanit ve 14 hastada (%36) grade 3 yanit mevcuttu. Patolojik tam yanit ile histopatolojik olarak perinoral invazyon olmamasi istatistiksel olarak anlamli iliski gosterdi (p=0,023). Sonuc: Calismamizda NAK alan LIMK'li hastalarda perinoral invazyon varliginin kemoterapiye kotu yanit ile iliskisi oldugu gorulmustur. Ayrica lenfovaskular invazyon ve dusuk grade mevcudiyetinde istatistiksel olarak anlamli olmasa da kemoterapiye kotu yanit gozlenmistir. Anahtar Kelimeler: Lokal ileri mide kanseri, neoadjuvan kemoterapi yaniti, patolojik tam yanit, perinoral invazyon</description><subject>Analysis</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Glycosylated hemoglobin</subject><subject>Neoadjuvant therapy</subject><subject>Patient outcomes</subject><subject>Risk factors</subject><subject>Stomach cancer</subject><issn>1305-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptjjtrwzAUhTW00JBm7XyhsxPJiuVoFLbsqHakICsFT8HxI7jkAU3_U_9mbVpoh3KH-zrn4yD0RPDcZyzAC7VTLonnPMBhQO7QhFAceGxJ6QOa3W5vGGM_ICTAywn6TETkjC1ga2WsIqd0ClYWW6MLCc6AlkbEL7tXoR1Ea7kxbi2t2JagNOQmEnlegoiHdyRjSEXhrIogGle7yE0mclC5tAo2KpaQiYFqlR7GXy5kI3WEqlJCKbRyCoxOjZUaEpEN6QbCI7rvqtOtnf30KXKJdNHay02qhhjekYWBR3HLmlWIG84qf1XVlV9xjv2mZrRjjFIcHla4WTb0wDvCsF-T5kD8uq3DhpKQB3SKnr-xx-rU7vtLd_14r-pzf6v3gnESMk7ZqJr_oxqqac99fb20XT_c_xi-AJAkbww</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Yildirim, Emine</creator><creator>Bektas, Sibel</creator><creator>Aydin, Sabin Goktas</creator><creator>Er, Ahmet Muzaffer</creator><creator>Yanik, Irem</creator><creator>Gumuskaya, Perihan Ozkan</creator><creator>Yilmaz, Barbaros Utku</creator><creator>Bilici, Ahmet</creator><creator>Oncel, Mustafa</creator><general>AVES</general><scope/></search><sort><creationdate>20220301</creationdate><title>FACTORS PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER/LOKAL ILERI MIDE KANSERINDE NEOADJUVAN KEMOTERAPIYE YANITI ONGOREN FAKTORLER</title><author>Yildirim, Emine ; Bektas, Sibel ; Aydin, Sabin Goktas ; Er, Ahmet Muzaffer ; Yanik, Irem ; Gumuskaya, Perihan Ozkan ; Yilmaz, Barbaros Utku ; Bilici, Ahmet ; Oncel, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g675-30e6d870d96a28aca2a9902dc63f663307b80d4d3b9f1602c1db12cec7d317953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Glycosylated hemoglobin</topic><topic>Neoadjuvant therapy</topic><topic>Patient outcomes</topic><topic>Risk factors</topic><topic>Stomach cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildirim, Emine</creatorcontrib><creatorcontrib>Bektas, Sibel</creatorcontrib><creatorcontrib>Aydin, Sabin Goktas</creatorcontrib><creatorcontrib>Er, Ahmet Muzaffer</creatorcontrib><creatorcontrib>Yanik, Irem</creatorcontrib><creatorcontrib>Gumuskaya, Perihan Ozkan</creatorcontrib><creatorcontrib>Yilmaz, Barbaros Utku</creatorcontrib><creatorcontrib>Bilici, Ahmet</creatorcontrib><creatorcontrib>Oncel, Mustafa</creatorcontrib><jtitle>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildirim, Emine</au><au>Bektas, Sibel</au><au>Aydin, Sabin Goktas</au><au>Er, Ahmet Muzaffer</au><au>Yanik, Irem</au><au>Gumuskaya, Perihan Ozkan</au><au>Yilmaz, Barbaros Utku</au><au>Bilici, Ahmet</au><au>Oncel, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FACTORS PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER/LOKAL ILERI MIDE KANSERINDE NEOADJUVAN KEMOTERAPIYE YANITI ONGOREN FAKTORLER</atitle><jtitle>İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine</jtitle><date>2022-03-01</date><risdate>2022</risdate><volume>85</volume><issue>1</issue><spage>41</spage><pages>41-</pages><issn>1305-6433</issn><abstract>Objective: In the treatment of local advanced gastric cancer (LAGC), it is recommended to start with neoadjuvant chemotherapy (NAC). Although the benefits of NAC have been shown, it is still not fully understood which patients respond better. The aim of this study was to investigate the effect of hematological and histopathological parameters on the response to chemotherapy. Materials and Methods: A retrospective examination was made of 38 patients who underwent surgery for LAGC after receiving NAC. Evaluations were made by comparing the demographic characteristics, histopathological characteristics in an endoscopic biopsy of the tumor, preoperative hemoglobin levels, and neutrophil-lymphocyte ratios with the postoperative pathological response to determine which tumor characteristics gave a better response. Results: In the postoperative histopathological evaluation, there was a pathological complete response to chemotherapy in two patients (6%), grade 1 in 9 patients (24%), grade 2 in 13 patients (34%), and grade 3 in 14 patients (36%). A statistically significant relationship was determined between the histopathological absence of perineural invasion and pathological complete response (p=0.023). Conclusion: A relationship between perineural invasion and poor response to chemotherapy was determined. Although not at a statistically significant level, there was also observed to be a poor response to chemotherapy in the presence of low grade and lymphovascular invasion. Keywords: Local advanced gastric cancer, neoadjuvant chemotherapy response, pathological complete response, perineural invasion Amac: Lokal ileri mide kanserinde (LIMK) tedaviye neoadjuvan kemoterapi (NAK) ile baslanmasi onerilir. Ancak NAK'nin faydalari gosterilmis olsa da hangi hasta gurubunun tedaviye daha iyi yanit verdigi tam olarak anlasilamamistir. Calismamizda hematolojik ve histopatolojik parametrelerin kemoterapi yaniti uzerine etkisi arastirilmistir. Yontem ve Gerec: Bu calismada lokal ileri evre mide kanseri nedeni ile neoadjuvan kemoterapi gorup sonrasinda ameliyat edilen 38 hasta retrospektif olarak incelendi. Ameliyat sonrasi patolojik yanit ile hastanin demografik ozellikleri, tumorun endoskopik biyopsideki histopatolojik ozellikleri, preoperatif hemoglobin seviyesi, notrofil lenfosit orani karsilastirilip hangi ozellikteki tumorlerin daha iyi yanit verdigi degerlendirildi. Bulgular: Ameliyat sonrasi yapilan histopatolojik degerlendirmede 2 (%6) hastada patolojik tam yanit, 9 (%24) hastada grade 1 yanit, 13 (%34) hastada grade 2 yanit ve 14 hastada (%36) grade 3 yanit mevcuttu. Patolojik tam yanit ile histopatolojik olarak perinoral invazyon olmamasi istatistiksel olarak anlamli iliski gosterdi (p=0,023). Sonuc: Calismamizda NAK alan LIMK'li hastalarda perinoral invazyon varliginin kemoterapiye kotu yanit ile iliskisi oldugu gorulmustur. Ayrica lenfovaskular invazyon ve dusuk grade mevcudiyetinde istatistiksel olarak anlamli olmasa da kemoterapiye kotu yanit gozlenmistir. Anahtar Kelimeler: Lokal ileri mide kanseri, neoadjuvan kemoterapi yaniti, patolojik tam yanit, perinoral invazyon</abstract><pub>AVES</pub><doi>10.26650/IUITFD.950751</doi></addata></record> |
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| identifier | ISSN: 1305-6433 |
| ispartof | İstanbul Tıp Fakültesi dergisi = Journal of the Istanbul Faculty of Medicine, 2022-03, Vol.85 (1), p.41 |
| issn | 1305-6433 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Analysis Care and treatment Diagnosis Glycosylated hemoglobin Neoadjuvant therapy Patient outcomes Risk factors Stomach cancer |
| title | FACTORS PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED GASTRIC CANCER/LOKAL ILERI MIDE KANSERINDE NEOADJUVAN KEMOTERAPIYE YANITI ONGOREN FAKTORLER |
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