Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy

Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in disease management. Here, we define a molecular pathw...

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Veröffentlicht in:	The Journal of clinical investigation 2022-01, Vol.132 (2)
Hauptverfasser:	van de Veerdonk, Frank L, Renga, Giorgia, Pariano, Marilena, Belle, Marina M, Servillo, Giuseppe, Fallarino, Francesca, De Luca, Antonella, Iannitti, Rossana G, Piobbico, Danilo, Gargaro, Marco, Manni, Giorgia, D'Onofrio, Fiorella, Stincardini, Claudia, Sforna, Luigi, Borghi, Monica, Castelli, Marilena, Pieroni, Stefania, Oikonomou, Vasileios, Villella, Valeria R, Puccetti, Matteo, Giovagnoli, Stefano, Galarini, Roberta, Barola, Carolina, Maiuri, Luigi, Fazia, Maria Agnese Della, Cellini, Barbara, Talesa, Vincenzo Nicola, Dinarello, Charles A, Costantini, Claudio, Romani, Luigina
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy (Cytology) Cellular proteins Health aspects Homeostasis Mitochondria Oxidation-reduction reaction Pharmacology, Experimental Physiological aspects
Online-Zugang:	Volltext
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