RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche and bone tropism are largely unknown. In this study, we report that osteoclast precursors (OPs) can function as a premetastatic niche component that...

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Veröffentlicht in:	The Journal of clinical investigation 2022-01, Vol.132 (2)
Hauptverfasser:	Yue, Zhiying, Niu, Xin, Yuan, Zengjin, Qin, Qin, Jiang, Wenhao, He, Liang, Gao, Jingduo, Ding, Yi, Liu, Yanxi, Xu, Ziwei, Li, Zhenxi, Yang, Zhengfeng, Li, Rong, Xue, Xiwen, Gao, Yankun, Yue, Fei, Zhang, Xiang H.-F, Hu, Guohong, Wang, Yi, Li, Yi, Chen, Geng, Siwko, Stefan, Gartland, Alison, Wang, Ning, Xiao, Jianru, Liu, Mingyao, Luo, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone cancer Cell receptors Cellular signal transduction Development and progression Genetic aspects Health aspects Metastasis Osteoclasts (Biology)
Online-Zugang:	Volltext
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