The association between melatonin levels and sleep quality in patients with pruritus: A potential biomarker on a candidate future treatment
Background: Melatonin is a hormone that regulates the sleep-wake cycle and has immunomodulatory and anti-inflammatory roles. Aims: The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with noc...
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| Veröffentlicht in: | Indian journal of dermatology 2021-11, Vol.66 (6), p.609-615 |
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| container_title | Indian journal of dermatology |
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| creator | Erdem, Yasemin Altunay, İlknur Özkur, Ezgi şekerlisoy, Gül Karabay, Ezgi Özdemir, Filiz Çerman, Aslı |
| description | Background: Melatonin is a hormone that regulates the sleep-wake cycle and has immunomodulatory and anti-inflammatory roles. Aims: The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with nocturnal pruritus. Methods: The study was a prospective study with 82 participants, including 41 patients and 41 healthy volunteers. The visual analog scale (VAS), Pittsburg Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were recorded for each patient. To assess the melatonin levels, urinary 6-sulfatoxymelatonin levels in the first urine in the morning were measured. Results: Melatonin concentrations were significantly lower (P = 0.007), while the BDI (P = 0.001) and PSQI (P = 0.001) scores were significantly higher in the patients with pruritus than in the healthy control subjects. There was an inverse correlation between melatonin levels and PSQI scores (r = −0.355, P = 0.023), and a positive correlation was detected between BDI scores and PSQI scores (r = 0.631, P = 0.001) in the pruritus group. Conclusion: Melatonin levels were found to decrease in relation to sleep quality in nocturnal pruritus patients. Low melatonin levels in these patients may be associated with sleep disorders and pruritus. |
| doi_str_mv | 10.4103/ijd.ijd_31_21 |
| format | Article |
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Aims: The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with nocturnal pruritus. Methods: The study was a prospective study with 82 participants, including 41 patients and 41 healthy volunteers. The visual analog scale (VAS), Pittsburg Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were recorded for each patient. To assess the melatonin levels, urinary 6-sulfatoxymelatonin levels in the first urine in the morning were measured. Results: Melatonin concentrations were significantly lower (P = 0.007), while the BDI (P = 0.001) and PSQI (P = 0.001) scores were significantly higher in the patients with pruritus than in the healthy control subjects. There was an inverse correlation between melatonin levels and PSQI scores (r = −0.355, P = 0.023), and a positive correlation was detected between BDI scores and PSQI scores (r = 0.631, P = 0.001) in the pruritus group. Conclusion: Melatonin levels were found to decrease in relation to sleep quality in nocturnal pruritus patients. Low melatonin levels in these patients may be associated with sleep disorders and pruritus.</description><identifier>ISSN: 0019-5154</identifier><identifier>EISSN: 1998-3611</identifier><identifier>DOI: 10.4103/ijd.ijd_31_21</identifier><identifier>PMID: 35283519</identifier><language>eng</language><publisher>MUMBAI: Wolters Kluwer India Pvt. Ltd</publisher><subject>Biomarkers ; Care and treatment ; Circadian rhythm ; Depression, Mental ; Dermatology ; Life Sciences & Biomedicine ; Medical research ; Medicine, Experimental ; Melatonin ; Mental depression ; Original ; Pruritus ; Science & Technology ; Skin diseases ; Sleep ; Sleep disorders</subject><ispartof>Indian journal of dermatology, 2021-11, Vol.66 (6), p.609-615</ispartof><rights>Copyright: © 2022 Indian Journal of Dermatology.</rights><rights>COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd.</rights><rights>2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2022 Indian Journal of Dermatology 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000756586700006</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c580t-f4d986f48224e2eb897a738c670b416050c01d8d71e488605cfc9b5019801a033</citedby><cites>FETCH-LOGICAL-c580t-f4d986f48224e2eb897a738c670b416050c01d8d71e488605cfc9b5019801a033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906312/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906312/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35283519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdem, Yasemin</creatorcontrib><creatorcontrib>Altunay, İlknur</creatorcontrib><creatorcontrib>Özkur, Ezgi</creatorcontrib><creatorcontrib>şekerlisoy, Gül</creatorcontrib><creatorcontrib>Karabay, Ezgi</creatorcontrib><creatorcontrib>Özdemir, Filiz</creatorcontrib><creatorcontrib>Çerman, Aslı</creatorcontrib><title>The association between melatonin levels and sleep quality in patients with pruritus: A potential biomarker on a candidate future treatment</title><title>Indian journal of dermatology</title><addtitle>INDIAN J DERMATOL</addtitle><addtitle>Indian J Dermatol</addtitle><description>Background: Melatonin is a hormone that regulates the sleep-wake cycle and has immunomodulatory and anti-inflammatory roles. Aims: The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with nocturnal pruritus. Methods: The study was a prospective study with 82 participants, including 41 patients and 41 healthy volunteers. The visual analog scale (VAS), Pittsburg Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were recorded for each patient. To assess the melatonin levels, urinary 6-sulfatoxymelatonin levels in the first urine in the morning were measured. Results: Melatonin concentrations were significantly lower (P = 0.007), while the BDI (P = 0.001) and PSQI (P = 0.001) scores were significantly higher in the patients with pruritus than in the healthy control subjects. There was an inverse correlation between melatonin levels and PSQI scores (r = −0.355, P = 0.023), and a positive correlation was detected between BDI scores and PSQI scores (r = 0.631, P = 0.001) in the pruritus group. Conclusion: Melatonin levels were found to decrease in relation to sleep quality in nocturnal pruritus patients. Low melatonin levels in these patients may be associated with sleep disorders and pruritus.</description><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Circadian rhythm</subject><subject>Depression, Mental</subject><subject>Dermatology</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Melatonin</subject><subject>Mental depression</subject><subject>Original</subject><subject>Pruritus</subject><subject>Science & Technology</subject><subject>Skin diseases</subject><subject>Sleep</subject><subject>Sleep disorders</subject><issn>0019-5154</issn><issn>1998-3611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2P0zAQhiMEYkvhyBVZ4oKEUux8OhxWqiq-pJW4LGfLcSatW8fO2s5W-xv400zZbmFRD9iyomSeeWc8eZPkNaOLgtH8g952CzwiZyJjT5IZaxqe5hVjT5MZpaxJS1YWF8mLELaUFjnj7HlykZcZz0vWzJKf1xsgMgSntIzaWdJC3ANYMoCR0VltiYFbMIFI25FgAEZyM0mj4x3B2IhJYGMgex03ZPST13EKH8mSjC5iQEtDWu0G6XfgCcpLolBIdzIC6ac4eSDRg4wDwi-TZ700AV4dn_Pkx-dP16uv6dX3L99Wy6tUlZzGtC-6hld9wbOsgAxa3tSyzrmqatoWrKIlVZR1vKsZFJzju-pV05Y4C06ZpHk-Ty7vdcepHaBTWNpLI0avsc874aQWjyNWb8Ta3Qre0CpnGQq8Owp4dzNBiGLQQYEx0oKbgsiqnDdFVmcU0bf_oFs3eYvXQyoryow1Nf9DraUBoW3vsK46iIpl1bCsqkvUnCfpGWoNFrBJZ6HX-PkRvzjD4-5g0OpswrGA8i4ED_1pJoyKg9vEwWkntyH_5u9BnugHeyHA74E9tK4PCr2i4IRRSuuyKjn-OFzVSsffFly5yUZMff__qUivjrQzEXzYmWkPXmBTO-v259sXFW0E2l882D__BfnJCwg</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Erdem, Yasemin</creator><creator>Altunay, İlknur</creator><creator>Özkur, Ezgi</creator><creator>şekerlisoy, Gül</creator><creator>Karabay, Ezgi</creator><creator>Özdemir, Filiz</creator><creator>Çerman, Aslı</creator><general>Wolters Kluwer India Pvt. 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Özkur, Ezgi ; şekerlisoy, Gül ; Karabay, Ezgi ; Özdemir, Filiz ; Çerman, Aslı</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-f4d986f48224e2eb897a738c670b416050c01d8d71e488605cfc9b5019801a033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Care and treatment</topic><topic>Circadian rhythm</topic><topic>Depression, Mental</topic><topic>Dermatology</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Melatonin</topic><topic>Mental depression</topic><topic>Original</topic><topic>Pruritus</topic><topic>Science & Technology</topic><topic>Skin diseases</topic><topic>Sleep</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdem, Yasemin</creatorcontrib><creatorcontrib>Altunay, İlknur</creatorcontrib><creatorcontrib>Özkur, Ezgi</creatorcontrib><creatorcontrib>şekerlisoy, Gül</creatorcontrib><creatorcontrib>Karabay, Ezgi</creatorcontrib><creatorcontrib>Özdemir, Filiz</creatorcontrib><creatorcontrib>Çerman, Aslı</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdem, Yasemin</au><au>Altunay, İlknur</au><au>Özkur, Ezgi</au><au>şekerlisoy, Gül</au><au>Karabay, Ezgi</au><au>Özdemir, Filiz</au><au>Çerman, Aslı</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between melatonin levels and sleep quality in patients with pruritus: A potential biomarker on a candidate future treatment</atitle><jtitle>Indian journal of dermatology</jtitle><stitle>INDIAN J DERMATOL</stitle><addtitle>Indian J Dermatol</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>66</volume><issue>6</issue><spage>609</spage><epage>615</epage><pages>609-615</pages><issn>0019-5154</issn><eissn>1998-3611</eissn><abstract>Background: Melatonin is a hormone that regulates the sleep-wake cycle and has immunomodulatory and anti-inflammatory roles. Aims: The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with nocturnal pruritus. Methods: The study was a prospective study with 82 participants, including 41 patients and 41 healthy volunteers. The visual analog scale (VAS), Pittsburg Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were recorded for each patient. To assess the melatonin levels, urinary 6-sulfatoxymelatonin levels in the first urine in the morning were measured. Results: Melatonin concentrations were significantly lower (P = 0.007), while the BDI (P = 0.001) and PSQI (P = 0.001) scores were significantly higher in the patients with pruritus than in the healthy control subjects. There was an inverse correlation between melatonin levels and PSQI scores (r = −0.355, P = 0.023), and a positive correlation was detected between BDI scores and PSQI scores (r = 0.631, P = 0.001) in the pruritus group. Conclusion: Melatonin levels were found to decrease in relation to sleep quality in nocturnal pruritus patients. Low melatonin levels in these patients may be associated with sleep disorders and pruritus.</abstract><cop>MUMBAI</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>35283519</pmid><doi>10.4103/ijd.ijd_31_21</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Care and treatment Circadian rhythm Depression, Mental Dermatology Life Sciences & Biomedicine Medical research Medicine, Experimental Melatonin Mental depression Original Pruritus Science & Technology Skin diseases Sleep Sleep disorders |
| title | The association between melatonin levels and sleep quality in patients with pruritus: A potential biomarker on a candidate future treatment |
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