Capsaicin ameliorate the nephrotoxicity induced by methotrexate
Although methotrexate (MTX) is an effective immunosuppressive and anti-cancer agent, it is associated with side effects, including nephrotoxicity. Capsaicin, a component of hot chilli peppers, induces rapid desensitization of TRPV1 pain receptors and therefore has uses in pain treatment. Capsaicin a...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2021-11, Vol.34 (6), p.2191 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Aldossary, Sara A Chohan, Muhammad Shahzad Mohaini, Mohammed Al Tasleem Rasool, Sahibzada |
| description | Although methotrexate (MTX) is an effective immunosuppressive and anti-cancer agent, it is associated with side effects, including nephrotoxicity. Capsaicin, a component of hot chilli peppers, induces rapid desensitization of TRPV1 pain receptors and therefore has uses in pain treatment. Capsaicin also has anti-cancer activity, including anti-inflammatory properties. Thus, capsaicin may have potential in preventing MTX-induced nephrotoxicity. The purpose of this research work was to observe protective effects of capsaicin towards renal toxicity caused by methotrexate and mechanisms responsible for these effects. As expected, capsaicin had nephroprotective effects in MTX-intoxicated rats. Serum creatinine urea, nitric oxide (NO) and renal malondialdehyde (MDA) levels decreased significantly, with a concurrent increase in superoxide dismutase (SOD) and renal glutathione peroxidase (GPx) activities as compared to rats that had been untreated with nephrotoxic. Biochemical analyses confirmed the protective effects of capsaicin. We conclude that capsaicin provides protection against MTX-nephrotoxicity in rats via anti-inflammatory and antioxidant activities. |
| doi_str_mv | 10.36721/PJPS.2021.34.6.REG.2191-2195.1 |
| format | Article |
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Capsaicin, a component of hot chilli peppers, induces rapid desensitization of TRPV1 pain receptors and therefore has uses in pain treatment. Capsaicin also has anti-cancer activity, including anti-inflammatory properties. Thus, capsaicin may have potential in preventing MTX-induced nephrotoxicity. The purpose of this research work was to observe protective effects of capsaicin towards renal toxicity caused by methotrexate and mechanisms responsible for these effects. As expected, capsaicin had nephroprotective effects in MTX-intoxicated rats. Serum creatinine urea, nitric oxide (NO) and renal malondialdehyde (MDA) levels decreased significantly, with a concurrent increase in superoxide dismutase (SOD) and renal glutathione peroxidase (GPx) activities as compared to rats that had been untreated with nephrotoxic. Biochemical analyses confirmed the protective effects of capsaicin. We conclude that capsaicin provides protection against MTX-nephrotoxicity in rats via anti-inflammatory and antioxidant activities.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2021.34.6.REG.2191-2195.1</identifier><identifier>PMID: 35034880</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; Capsaicin ; Capsaicin - pharmacology ; Care and treatment ; Complications and side effects ; Disease Models, Animal ; Drugs ; Health aspects ; Inflammation Mediators - metabolism ; Kidney - drug effects ; Kidney - metabolism ; Kidney - pathology ; Kidney diseases ; Kidney Diseases - chemically induced ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Kidney Diseases - prevention & control ; Male ; Methotrexate ; Oxidative Stress - drug effects ; Pharmacology, Experimental ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2021-11, Vol.34 (6), p.2191</ispartof><rights>COPYRIGHT 2021 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35034880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aldossary, Sara A</creatorcontrib><creatorcontrib>Chohan, Muhammad Shahzad</creatorcontrib><creatorcontrib>Mohaini, Mohammed Al</creatorcontrib><creatorcontrib>Tasleem Rasool, Sahibzada</creatorcontrib><title>Capsaicin ameliorate the nephrotoxicity induced by methotrexate</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Although methotrexate (MTX) is an effective immunosuppressive and anti-cancer agent, it is associated with side effects, including nephrotoxicity. Capsaicin, a component of hot chilli peppers, induces rapid desensitization of TRPV1 pain receptors and therefore has uses in pain treatment. Capsaicin also has anti-cancer activity, including anti-inflammatory properties. Thus, capsaicin may have potential in preventing MTX-induced nephrotoxicity. The purpose of this research work was to observe protective effects of capsaicin towards renal toxicity caused by methotrexate and mechanisms responsible for these effects. As expected, capsaicin had nephroprotective effects in MTX-intoxicated rats. Serum creatinine urea, nitric oxide (NO) and renal malondialdehyde (MDA) levels decreased significantly, with a concurrent increase in superoxide dismutase (SOD) and renal glutathione peroxidase (GPx) activities as compared to rats that had been untreated with nephrotoxic. Biochemical analyses confirmed the protective effects of capsaicin. We conclude that capsaicin provides protection against MTX-nephrotoxicity in rats via anti-inflammatory and antioxidant activities.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Disease Models, Animal</subject><subject>Drugs</subject><subject>Health aspects</subject><subject>Inflammation Mediators - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - prevention & control</subject><subject>Male</subject><subject>Methotrexate</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology, Experimental</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AQhveg2Fr9CxLw4CnrTHazyZ6klLYqBYsf4C1sNrPtSvNBkkL77w1UD4IMvAMzz_syDGN3CFyoJML79fP6jUcQIReSK_46X_IINYaDxBzP2BgBMVSAnyN22XVfAEpqrS_YSMQgZJrCmD3MTNMZb30VmJJ2vm5NT0G_paCiZtvWfX0Ylv0x8FWxt1QE-TEoqd_WfUuHAb1i587sOrr-6RP2sZi_zx7D1cvyaTZdhZsoSfvQkLa5TAEtELki1XGuXUFkAMCBQpO6hJzIIdZSorYyUQlRDlpgpJUsxITdnnI3ZkeZr9xwgLGl72w2VanWSRIpHCj-DzVUQaW3dUXOD_M_hpuTodnnJRVZ0_rStMfs90HiG8FTaQU</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Aldossary, Sara A</creator><creator>Chohan, Muhammad Shahzad</creator><creator>Mohaini, Mohammed Al</creator><creator>Tasleem Rasool, Sahibzada</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202111</creationdate><title>Capsaicin ameliorate the nephrotoxicity induced by methotrexate</title><author>Aldossary, Sara A ; Chohan, Muhammad Shahzad ; Mohaini, Mohammed Al ; Tasleem Rasool, Sahibzada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-ae9cb4801c0eefd895b9fdeea000f061a8f7ef3b0594419c4767eeb09312964d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Disease Models, Animal</topic><topic>Drugs</topic><topic>Health aspects</topic><topic>Inflammation Mediators - metabolism</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - prevention & control</topic><topic>Male</topic><topic>Methotrexate</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology, Experimental</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aldossary, Sara A</creatorcontrib><creatorcontrib>Chohan, Muhammad Shahzad</creatorcontrib><creatorcontrib>Mohaini, Mohammed Al</creatorcontrib><creatorcontrib>Tasleem Rasool, Sahibzada</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aldossary, Sara A</au><au>Chohan, Muhammad Shahzad</au><au>Mohaini, Mohammed Al</au><au>Tasleem Rasool, Sahibzada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsaicin ameliorate the nephrotoxicity induced by methotrexate</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2021-11</date><risdate>2021</risdate><volume>34</volume><issue>6</issue><spage>2191</spage><pages>2191-</pages><issn>1011-601X</issn><abstract>Although methotrexate (MTX) is an effective immunosuppressive and anti-cancer agent, it is associated with side effects, including nephrotoxicity. Capsaicin, a component of hot chilli peppers, induces rapid desensitization of TRPV1 pain receptors and therefore has uses in pain treatment. Capsaicin also has anti-cancer activity, including anti-inflammatory properties. Thus, capsaicin may have potential in preventing MTX-induced nephrotoxicity. The purpose of this research work was to observe protective effects of capsaicin towards renal toxicity caused by methotrexate and mechanisms responsible for these effects. As expected, capsaicin had nephroprotective effects in MTX-intoxicated rats. Serum creatinine urea, nitric oxide (NO) and renal malondialdehyde (MDA) levels decreased significantly, with a concurrent increase in superoxide dismutase (SOD) and renal glutathione peroxidase (GPx) activities as compared to rats that had been untreated with nephrotoxic. Biochemical analyses confirmed the protective effects of capsaicin. We conclude that capsaicin provides protection against MTX-nephrotoxicity in rats via anti-inflammatory and antioxidant activities.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>35034880</pmid><doi>10.36721/PJPS.2021.34.6.REG.2191-2195.1</doi></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Capsaicin Capsaicin - pharmacology Care and treatment Complications and side effects Disease Models, Animal Drugs Health aspects Inflammation Mediators - metabolism Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney diseases Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Male Methotrexate Oxidative Stress - drug effects Pharmacology, Experimental Rats Rats, Sprague-Dawley |
| title | Capsaicin ameliorate the nephrotoxicity induced by methotrexate |
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