Impact of self-reported family history on some metabolic markers of type 2 diabetic patients

Context: Family history of type 2 diabetes mellitus (T2DM), hypertension (HTN) and obesity, are known non-modifiable, independent and easily assessed risk factors for incident type 2 diabetes. Aims: This study was aimed at assessing the effect of self-reported family history on the levels of some me...

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Veröffentlicht in:Nigerian journal of basic and clinical sciences 2021-07, Vol.18 (2), p.145-152
Hauptverfasser: Muazu, Salisu, Bako, Hauwa, Nwakasi, Nnamah, Taofeeq, Oduola, Bello, Kabiru, Sani, Usman, Bello, Ahmad
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container_end_page 152
container_issue 2
container_start_page 145
container_title Nigerian journal of basic and clinical sciences
container_volume 18
creator Muazu, Salisu
Bako, Hauwa
Nwakasi, Nnamah
Taofeeq, Oduola
Bello, Kabiru
Sani, Usman
Bello, Ahmad
description Context: Family history of type 2 diabetes mellitus (T2DM), hypertension (HTN) and obesity, are known non-modifiable, independent and easily assessed risk factors for incident type 2 diabetes. Aims: This study was aimed at assessing the effect of self-reported family history on the levels of some metabolic markers (total homocysteine [tHcy], high sensitivity C-reactive protein [hs-CRP] and glycated haemoglobin [HbA1c]) among patients with type 2 diabetes. Settings and Design: Two hundred and forty participants subdivided into Group 1 (T2DM only), Group 2 (T2DM diagnosed with HTN) and Group 3 (controls) were enrolled in a cross-sectional pattern. Subjects and Methods: A structured questionnaire was used to obtain information on self-reported family history. Biochemical parameters were assayed using standard laboratory procedures. Statistical Analysis Used: SPSS version 20.0 was used for statistical analysis with significance at P ≤ 0.05. Results: Group 1: Family history of type 2 diabetes (FHD) (HbA1c, P < 0.001, fasting plasma glucose [FPG], P = 0.005, triglycerides [TG], P = 0.049), family history of HTN (FHTN) (HbA1c, P < 0.001, FPG P = 0.005), family history of obesity (FHO) (HbA1c, P < 0.001, high-density lipoprotein cholesterol [HDL-C], P = 0.049). Group 2: FHD (tHcy, P = 0.021, HDL-C, P = 0.026), FHTN (tHcy, P = 0.035), FHO (HbA1c, P = 0.003, FPG, P = 0.001, TC, P < 0.001, TG, P = 0.019, LDL-C, P = 0.001). Group 3: FHD (tHcy, P = 0.004, HDL-C, P = 0.035), FHTN (FPG, P < 0.001, tHcy P = 0.010, TC, P = 0.037, TG, P = 0.003), FHO (hs-CRP, P < 0.001, HDL-C, P = 0.007, TG P = 0.001, LDL-C P = 0.019). Conclusions: Self-reported positive family history may provide insights into the biochemical and metabolic profile of patients with type 2 diabetes.
doi_str_mv 10.4103/njbcs.njbcs_4_21
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Aims: This study was aimed at assessing the effect of self-reported family history on the levels of some metabolic markers (total homocysteine [tHcy], high sensitivity C-reactive protein [hs-CRP] and glycated haemoglobin [HbA1c]) among patients with type 2 diabetes. Settings and Design: Two hundred and forty participants subdivided into Group 1 (T2DM only), Group 2 (T2DM diagnosed with HTN) and Group 3 (controls) were enrolled in a cross-sectional pattern. Subjects and Methods: A structured questionnaire was used to obtain information on self-reported family history. Biochemical parameters were assayed using standard laboratory procedures. Statistical Analysis Used: SPSS version 20.0 was used for statistical analysis with significance at P ≤ 0.05. Results: Group 1: Family history of type 2 diabetes (FHD) (HbA1c, P < 0.001, fasting plasma glucose [FPG], P = 0.005, triglycerides [TG], P = 0.049), family history of HTN (FHTN) (HbA1c, P < 0.001, FPG P = 0.005), family history of obesity (FHO) (HbA1c, P < 0.001, high-density lipoprotein cholesterol [HDL-C], P = 0.049). Group 2: FHD (tHcy, P = 0.021, HDL-C, P = 0.026), FHTN (tHcy, P = 0.035), FHO (HbA1c, P = 0.003, FPG, P = 0.001, TC, P < 0.001, TG, P = 0.019, LDL-C, P = 0.001). Group 3: FHD (tHcy, P = 0.004, HDL-C, P = 0.035), FHTN (FPG, P < 0.001, tHcy P = 0.010, TC, P = 0.037, TG, P = 0.003), FHO (hs-CRP, P < 0.001, HDL-C, P = 0.007, TG P = 0.001, LDL-C P = 0.019). Conclusions: Self-reported positive family history may provide insights into the biochemical and metabolic profile of patients with type 2 diabetes.]]></description><identifier>ISSN: 0331-8540</identifier><identifier>DOI: 10.4103/njbcs.njbcs_4_21</identifier><language>eng</language><publisher>Wolters Kluwer India Pvt. 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Aims: This study was aimed at assessing the effect of self-reported family history on the levels of some metabolic markers (total homocysteine [tHcy], high sensitivity C-reactive protein [hs-CRP] and glycated haemoglobin [HbA1c]) among patients with type 2 diabetes. Settings and Design: Two hundred and forty participants subdivided into Group 1 (T2DM only), Group 2 (T2DM diagnosed with HTN) and Group 3 (controls) were enrolled in a cross-sectional pattern. Subjects and Methods: A structured questionnaire was used to obtain information on self-reported family history. Biochemical parameters were assayed using standard laboratory procedures. Statistical Analysis Used: SPSS version 20.0 was used for statistical analysis with significance at P ≤ 0.05. Results: Group 1: Family history of type 2 diabetes (FHD) (HbA1c, P < 0.001, fasting plasma glucose [FPG], P = 0.005, triglycerides [TG], P = 0.049), family history of HTN (FHTN) (HbA1c, P < 0.001, FPG P = 0.005), family history of obesity (FHO) (HbA1c, P < 0.001, high-density lipoprotein cholesterol [HDL-C], P = 0.049). Group 2: FHD (tHcy, P = 0.021, HDL-C, P = 0.026), FHTN (tHcy, P = 0.035), FHO (HbA1c, P = 0.003, FPG, P = 0.001, TC, P < 0.001, TG, P = 0.019, LDL-C, P = 0.001). Group 3: FHD (tHcy, P = 0.004, HDL-C, P = 0.035), FHTN (FPG, P < 0.001, tHcy P = 0.010, TC, P = 0.037, TG, P = 0.003), FHO (hs-CRP, P < 0.001, HDL-C, P = 0.007, TG P = 0.001, LDL-C P = 0.019). Conclusions: Self-reported positive family history may provide insights into the biochemical and metabolic profile of patients with type 2 diabetes.]]></description><subject>C-reactive protein</subject><subject>Care and treatment</subject><subject>Diabetics</subject><subject>Family</subject><subject>Glycosylated hemoglobin</subject><subject>Health aspects</subject><subject>Hypertension</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Risk factors</subject><subject>Type 2 diabetes</subject><issn>0331-8540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kd9LwzAQx_Og4Jh79zHgc2fSpGn3OIa_YCCCvgkhTS-arW1KEhn9782sIAO9gzu4u8_BfQ-hK0qWnBJ20-9qHZbfUXKZ0zM0I4zRrCo4uUCLEHYkWclJLtgMvT12g9IRO4MDtCbzMDgfocFGdbYd8YcN0fkRux4H1wHuIKratVbjTvk9-HAk4zgAznFjVQ0xtQYVLfQxXKJzo9oAi588R693ty-bh2z7dP-4WW8zzVjZZFUOTaOKShtRMcqBFjUtClbVFSc1EWUFTVmUSuSEiBXTdEVEIXIGNTdcC6bZHF1Pe99VC9L2xkWvdGeDlmtRiRUX6dw0tfxjKnkDndWuB2NT_QQgE6C9C8GDkYO36exRUiKPWstJ5V-tE_I8IQfXxqTOvv08gJcdNPveHf7lJOWFnD4hnZEnn2BfB1KTxQ</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Muazu, Salisu</creator><creator>Bako, Hauwa</creator><creator>Nwakasi, Nnamah</creator><creator>Taofeeq, Oduola</creator><creator>Bello, Kabiru</creator><creator>Sani, Usman</creator><creator>Bello, Ahmad</creator><general>Wolters Kluwer India Pvt. 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Aims: This study was aimed at assessing the effect of self-reported family history on the levels of some metabolic markers (total homocysteine [tHcy], high sensitivity C-reactive protein [hs-CRP] and glycated haemoglobin [HbA1c]) among patients with type 2 diabetes. Settings and Design: Two hundred and forty participants subdivided into Group 1 (T2DM only), Group 2 (T2DM diagnosed with HTN) and Group 3 (controls) were enrolled in a cross-sectional pattern. Subjects and Methods: A structured questionnaire was used to obtain information on self-reported family history. Biochemical parameters were assayed using standard laboratory procedures. Statistical Analysis Used: SPSS version 20.0 was used for statistical analysis with significance at P ≤ 0.05. Results: Group 1: Family history of type 2 diabetes (FHD) (HbA1c, P < 0.001, fasting plasma glucose [FPG], P = 0.005, triglycerides [TG], P = 0.049), family history of HTN (FHTN) (HbA1c, P < 0.001, FPG P = 0.005), family history of obesity (FHO) (HbA1c, P < 0.001, high-density lipoprotein cholesterol [HDL-C], P = 0.049). Group 2: FHD (tHcy, P = 0.021, HDL-C, P = 0.026), FHTN (tHcy, P = 0.035), FHO (HbA1c, P = 0.003, FPG, P = 0.001, TC, P < 0.001, TG, P = 0.019, LDL-C, P = 0.001). Group 3: FHD (tHcy, P = 0.004, HDL-C, P = 0.035), FHTN (FPG, P < 0.001, tHcy P = 0.010, TC, P = 0.037, TG, P = 0.003), FHO (hs-CRP, P < 0.001, HDL-C, P = 0.007, TG P = 0.001, LDL-C P = 0.019). Conclusions: Self-reported positive family history may provide insights into the biochemical and metabolic profile of patients with type 2 diabetes.]]></abstract><pub>Wolters Kluwer India Pvt. Ltd</pub><doi>10.4103/njbcs.njbcs_4_21</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects C-reactive protein
Care and treatment
Diabetics
Family
Glycosylated hemoglobin
Health aspects
Hypertension
Medical research
Medicine, Experimental
Risk factors
Type 2 diabetes
title Impact of self-reported family history on some metabolic markers of type 2 diabetic patients
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