Determination of TLC fingerprint biomarker of Ipomoea batatas (L.) Lam leaves extracted with ethanol and its potential as antihyperglycemic agent

Determination of TLC fingerprint biomarker of Ipomoea batatas (L.) Lam leaves extracted with ethanol and its potential as antihyperglycemic agent

Antihyperglycemic activity of Ipomoea batatas (L.) leaves has been studied for years. As many naturally found varieties of such plant species have been used as herbal medicines, there is a need to establish a fingerprint biomarker standardization method. Our research combined TLC fingerprints and ch...

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Veröffentlicht in:Farmacija 2021-12, Vol.68 (4), p.907-917
Hauptverfasser: Yustiantara, Putu Sanna, Warditiani, Ni Kadek, Sari, Pande Made Nova Armita, Dewi, Ni Luh Kade Arman Anita, Ramona, Yan, Jawi, I Made, Wirasuta, I Made Agus Gelgel
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Acetaldehyde
Alcohol
Alcohol, Denatured
Blood sugar
Diabetics
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container_issue 4
container_start_page 907
container_title Farmacija
container_volume 68
creator Yustiantara, Putu Sanna
Warditiani, Ni Kadek
Sari, Pande Made Nova Armita
Dewi, Ni Luh Kade Arman Anita
Ramona, Yan
Jawi, I Made
Wirasuta, I Made Agus Gelgel
description Antihyperglycemic activity of Ipomoea batatas (L.) leaves has been studied for years. As many naturally found varieties of such plant species have been used as herbal medicines, there is a need to establish a fingerprint biomarker standardization method. Our research combined TLC fingerprints and chemometric analysis to determine biomarkers in leaf ethanol extract of Ipomoea batatas (L.) (EIBL). We predicted the main constituents of anthocyanin glycosides and their acylated derivates in the leaf ethanol extract of such plants using ESI-MS. The EIBL that contained identified biomarkers has succeeded in providing an antihyperglycemic effect in experimental using STZ-induced rats. This study also found a linear correlation between doses of flavonoid derivates as antioxidant agents with their antihyperglycemic activities. Therefore, this biomarker information can be used as a model to predict the dose-responses of the antihyperglycemic activities produced by other leaf ethanol extracts of I. batatas .
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subjects Acetaldehyde
Alcohol
Alcohol, Denatured
Blood sugar
Diabetics
title Determination of TLC fingerprint biomarker of Ipomoea batatas (L.) Lam leaves extracted with ethanol and its potential as antihyperglycemic agent
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