PRODUCTION OF A SHORT-LIVED THERAPEUTIC [alpha]-EMITTER [sup.149]Tb BY IRRADIATION OF EUROPIUM BY 63 MeV [alpha]-PARTICLES
[sup.149]Tb is currently considered to be a promising [alpha]-emitting isotope radioimmunotherapy. It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of [Eu.sub.2][O.sub.3] with 4He with energy 63 MeV. After irradiation, radiochemical separation of te...
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| Veröffentlicht in: | Atomic energy (New York, N.Y.) N.Y.), 2021-08, Vol.129 (6), p.337 |
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| container_title | Atomic energy (New York, N.Y.) |
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| creator | Aliev, R.A Zagryadskiy, V.A Latushkin, S.T Moiseeva, A.N Novikov, V.I Unezhev, V.N Kazakov, A.G |
| description | [sup.149]Tb is currently considered to be a promising [alpha]-emitting isotope radioimmunotherapy. It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of [Eu.sub.2][O.sub.3] with 4He with energy 63 MeV. After irradiation, radiochemical separation of terbium radioisotopes was performed in a time not exceeding the half-life of [sup.149]Tb (4.12 h). It was based on reductive co-precipitation of europium and extraction-chromatographic purification. The obtained product, including [sup.149]Tb and the associated terbium radioisotopes, were analyzed by means of alpha- and gamma-spectrometry. It was concluded that the combination and sequence of approaches used in this work allow rapid production of short-lived [sup.149]Tb and the use of the technological route implemented in this work in practice. |
| doi_str_mv | 10.1007/s10512-021-00758-z |
| format | Article |
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It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of [Eu.sub.2][O.sub.3] with 4He with energy 63 MeV. After irradiation, radiochemical separation of terbium radioisotopes was performed in a time not exceeding the half-life of [sup.149]Tb (4.12 h). It was based on reductive co-precipitation of europium and extraction-chromatographic purification. The obtained product, including [sup.149]Tb and the associated terbium radioisotopes, were analyzed by means of alpha- and gamma-spectrometry. It was concluded that the combination and sequence of approaches used in this work allow rapid production of short-lived [sup.149]Tb and the use of the technological route implemented in this work in practice.</description><identifier>ISSN: 1063-4258</identifier><identifier>EISSN: 1573-8205</identifier><identifier>DOI: 10.1007/s10512-021-00758-z</identifier><language>eng</language><publisher>Springer</publisher><subject>Health aspects ; Immunotherapy</subject><ispartof>Atomic energy (New York, N.Y.), 2021-08, Vol.129 (6), p.337</ispartof><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids></links><search><creatorcontrib>Aliev, R.A</creatorcontrib><creatorcontrib>Zagryadskiy, V.A</creatorcontrib><creatorcontrib>Latushkin, S.T</creatorcontrib><creatorcontrib>Moiseeva, A.N</creatorcontrib><creatorcontrib>Novikov, V.I</creatorcontrib><creatorcontrib>Unezhev, V.N</creatorcontrib><creatorcontrib>Kazakov, A.G</creatorcontrib><title>PRODUCTION OF A SHORT-LIVED THERAPEUTIC [alpha]-EMITTER [sup.149]Tb BY IRRADIATION OF EUROPIUM BY 63 MeV [alpha]-PARTICLES</title><title>Atomic energy (New York, N.Y.)</title><description>[sup.149]Tb is currently considered to be a promising [alpha]-emitting isotope radioimmunotherapy. It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of [Eu.sub.2][O.sub.3] with 4He with energy 63 MeV. After irradiation, radiochemical separation of terbium radioisotopes was performed in a time not exceeding the half-life of [sup.149]Tb (4.12 h). It was based on reductive co-precipitation of europium and extraction-chromatographic purification. The obtained product, including [sup.149]Tb and the associated terbium radioisotopes, were analyzed by means of alpha- and gamma-spectrometry. It was concluded that the combination and sequence of approaches used in this work allow rapid production of short-lived [sup.149]Tb and the use of the technological route implemented in this work in practice.</description><subject>Health aspects</subject><subject>Immunotherapy</subject><issn>1063-4258</issn><issn>1573-8205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNptjFtLwzAYhosoOKd_wKuAV15kJmnTJpe1y1ygsyVLBzLGyNp0VjY3zAayX2_FAw7ku_hOz_t43jVGPYxQdOcwophARDBsV8rg4cTrYBr5kBFET9sZhT4MCGXn3oVzLwghHnLW8Q65yvpFomX2CLIBiMF4mCkNUzkRfaCHQsW5KLRMwNSsts9mBsVIai0UmLr9tocDPtMLcP8EpFJxX8Y_HlGoLJfF6PMV-mBkJ7-CPFatLxXjS--sNitnr7571ysGQidDmGYPMolTuMQIY0hpTSJsIstJEJiwKnlVkiC0PqkCziLG6YKWiAUlN9gQTupFxXgd-REitSmN9bvezZd3aVZ23rzWm92bKdeNK-dxyDANIkZxS_X-odqq7LopN6-2btr7UeD2KNAyO_u-W5q9c3M5Vn_ZD_9NdEg</recordid><startdate>20210819</startdate><enddate>20210819</enddate><creator>Aliev, R.A</creator><creator>Zagryadskiy, V.A</creator><creator>Latushkin, S.T</creator><creator>Moiseeva, A.N</creator><creator>Novikov, V.I</creator><creator>Unezhev, V.N</creator><creator>Kazakov, A.G</creator><general>Springer</general><scope>ISR</scope></search><sort><creationdate>20210819</creationdate><title>PRODUCTION OF A SHORT-LIVED THERAPEUTIC [alpha]-EMITTER [sup.149]Tb BY IRRADIATION OF EUROPIUM BY 63 MeV [alpha]-PARTICLES</title><author>Aliev, R.A ; Zagryadskiy, V.A ; Latushkin, S.T ; Moiseeva, A.N ; Novikov, V.I ; Unezhev, V.N ; Kazakov, A.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1011-55f271a7e9244a6dc9dc246e32d4987895b5c084c9a1a292fbd89f73702facae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Health aspects</topic><topic>Immunotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aliev, R.A</creatorcontrib><creatorcontrib>Zagryadskiy, V.A</creatorcontrib><creatorcontrib>Latushkin, S.T</creatorcontrib><creatorcontrib>Moiseeva, A.N</creatorcontrib><creatorcontrib>Novikov, V.I</creatorcontrib><creatorcontrib>Unezhev, V.N</creatorcontrib><creatorcontrib>Kazakov, A.G</creatorcontrib><collection>Gale In Context: Science</collection><jtitle>Atomic energy (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aliev, R.A</au><au>Zagryadskiy, V.A</au><au>Latushkin, S.T</au><au>Moiseeva, A.N</au><au>Novikov, V.I</au><au>Unezhev, V.N</au><au>Kazakov, A.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PRODUCTION OF A SHORT-LIVED THERAPEUTIC [alpha]-EMITTER [sup.149]Tb BY IRRADIATION OF EUROPIUM BY 63 MeV [alpha]-PARTICLES</atitle><jtitle>Atomic energy (New York, N.Y.)</jtitle><date>2021-08-19</date><risdate>2021</risdate><volume>129</volume><issue>6</issue><spage>337</spage><pages>337-</pages><issn>1063-4258</issn><eissn>1573-8205</eissn><abstract>[sup.149]Tb is currently considered to be a promising [alpha]-emitting isotope radioimmunotherapy. It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of [Eu.sub.2][O.sub.3] with 4He with energy 63 MeV. After irradiation, radiochemical separation of terbium radioisotopes was performed in a time not exceeding the half-life of [sup.149]Tb (4.12 h). It was based on reductive co-precipitation of europium and extraction-chromatographic purification. The obtained product, including [sup.149]Tb and the associated terbium radioisotopes, were analyzed by means of alpha- and gamma-spectrometry. It was concluded that the combination and sequence of approaches used in this work allow rapid production of short-lived [sup.149]Tb and the use of the technological route implemented in this work in practice.</abstract><pub>Springer</pub><doi>10.1007/s10512-021-00758-z</doi><tpages>4</tpages></addata></record> |
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| subjects | Health aspects Immunotherapy |
| title | PRODUCTION OF A SHORT-LIVED THERAPEUTIC [alpha]-EMITTER [sup.149]Tb BY IRRADIATION OF EUROPIUM BY 63 MeV [alpha]-PARTICLES |
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