Mechanistic basis of post-treatment control of SIV after anti-[alpha]4[beta]7 antibody therapy

Treating macaques with an anti-[alpha]4[beta]7 antibody under the umbrella of combination antiretroviral therapy (cART) during early SIV infection can lead to viral remission, with viral loads maintained at < 50 SIV RNA copies/ml after removal of all treatment in a subset of animals. Depletion of...

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Veröffentlicht in:	PLoS computational biology 2021-06, Vol.17 (6)
Hauptverfasser:	Wells, Chad R, Cao, Youfang, Durham, David P, Byrareddy, Siddappa N, Ansari, Aftab A, Ruddle, Nancy H, Townsend, Jeffrey P, Galvani, Alison P, Perelson, Alan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Control Drug therapy Highly active antiretroviral therapy HIV infection Immune response Physiological aspects Properties Simian immunodeficiency virus
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