Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-?B pathways

Background To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) development. Methods Ten-week-old male C57BL/6 mice were randomized and assign...

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Veröffentlicht in:	Arthritis research & therapy 2021-05, Vol.23 (1)
Hauptverfasser:	Lu, Jiansen, Zhang, Hongbo, Pan, Jianying, Hu, Zhiqiang, Liu, Liangliang, Liu, Yanli, Yu, Xiao, Bai, Xiaochun, Cai, Daozhang, Zhang, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological response modifiers Care and treatment Cellular signal transduction Development and progression Genetic aspects Health aspects Macrophages Magnolia Materia medica, Vegetable Mitogen-activated protein kinases Osteoarthritis Pharmacology, Experimental Plant extracts Polyphenols
Online-Zugang:	Volltext
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