Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-[gamma] signature

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-[gamma] within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-[gamma] which triggers their ability to kill the intracellular parasites. Consistent with this, trans...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	PLoS neglected tropical diseases 2021-04, Vol.15 (4)
Hauptverfasser:	Farias Amorim, Camila, O. Novais, Fernanda, Nguyen, Ba T, Nascimento, Mauricio T, Lago, Jamile, Lago, Alexsandro S, Carvalho, Lucas P, Beiting, Daniel P, Scott, Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Development and progression Genetic aspects Health aspects Immune response Inflammation Interferon gamma Leishmaniasis, Cutaneous T cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!