Pharmacological inhibition of nSMase2 reduces brain exosome release and [alpha]-synuclein pathology in a Parkinson's disease model

Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation. The enzyme nSMase2 is involved in the production of exosomes carryin...

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Veröffentlicht in:	Molecular brain 2021-04, Vol.14 (1)
Hauptverfasser:	Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Enzymes Interleukins
Online-Zugang:	Volltext
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