MITOL-dependent ubiquitylation negatively regulates the entry of Pol[gamma]A into mitochondria

Mutations in mitochondrial replicative polymerase Pol[gamma]A lead to progressive external ophthalmoplegia (PEO). While Pol[gamma]A is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the mitochondrial outer membrane which contro...

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Veröffentlicht in:	PLoS biology 2021-03, Vol.19 (3)
Hauptverfasser:	Hussain, Mansoor, Mohammed, Aftab, Saifi, Shabnam, Khan, Aamir, Kaur, Ekjot, Priya, Swati, Agarwal, Himanshi, Sengupta, Sagar
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Ligases Methods Mitochondrial DNA Ubiquitin Ubiquitin-proteasome system
Online-Zugang:	Volltext
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