Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study
Background: A reliable, migraine-specific biomarker has not been identified so far. Calcitonin Gene-Related Peptide (CGRP) and Apolipoprotein E (ApoE) might serve as migraine biomarkers due to their roles in migraine pathophysiology. However, their diagnostic usefulness has not been explored yet. Pr...
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| Veröffentlicht in: | International journal of general medicine 2021-03, Vol.14, p.851 |
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| creator | Latif, Rabia Rafique, Nazish Asoom, Lubna Al Alsunni, Ahmed A Salem, Ayad Mohammed AINoaimi, Dinah Abdulhadi AlHarbi, Wasan Mohammed Shaikh, Ahad Yasir AIRaddadi, Shoug Abdullah AIMuhaish, Leena Abdulrahman Almohazey, Dana Abdulazeez, Sayed Borgio, J. Francis |
| description | Background: A reliable, migraine-specific biomarker has not been identified so far. Calcitonin Gene-Related Peptide (CGRP) and Apolipoprotein E (ApoE) might serve as migraine biomarkers due to their roles in migraine pathophysiology. However, their diagnostic usefulness has not been explored yet. Present study explored the diagnostic accuracy of CGRP and ApoE in migraine. Methods: A cross-sectional, case-control study was conducted from November 2019 to April 2020 at Physiology department of our university. Fourteen female migraine patients, 18-25 years old, with confirmed "Migraine" diagnosis by a neurologist, were recruited. Control group consisted of 14 age-matched healthy females with no personal/family history of migraine. Blood was drawn once from control subjects and twice from migraine patients (ictal and interictal phase). Serum CGRP and ApoE levels were assessed by ELISA. Statistical analysis involved paired f-test, one-way ANOVA, Receiver operating characteristic (ROC) curves and cross-tabs. Results: ApoE (mg/dl) was higher significantly in interictal (1.90[+ or -]0.50) and ictal (1.97[+ or -]0.65) phases of migraine compared to control (1.07[+ or -]0.26) (p < 0.001). ROC curves for ApoE were significant in migraine ictal vs control (AUC= 0.91, AUC 95% CI: 0.78-1.0) and migraine interictal vs control (AUC=0.92, AUC 95% CI: 0.8-1.0) subjects. ROC curve for CGRP (pg/mL) was significant in migraine ictal vs control subjects only (AUC=0.79, AUC 95% CI: 0.6-0.97). Conclusion: Serum ApoE has "excellent" accuracy to diagnose migraine patients whether in ictal or interictal phase, from healthy subjects. ApoE levels of patients in these two phases of migraine are raised significantly than healthy subjects. CGRP has "fair" diagnostic accuracy to discriminate between migraine ictal phase and healthy subjects. Its levels do not differ significantly among migraine ictal, interictal phase and healthy controls. Keywords: apolipoprotein E, calcitonin gene-related peptide, migraine, receiver operating curve, biomarkers |
| doi_str_mv | 10.2l47/IJGM.S303350 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A658505056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A658505056</galeid><sourcerecordid>A658505056</sourcerecordid><originalsourceid>FETCH-LOGICAL-g676-a79126ae0bfab440f3e8e956151023c36ff3bc0ccf63dcd4fcbb217fdb9e88aa3</originalsourceid><addsrcrecordid>eNptj0FLAzEQhYMoWKs3f0DA89Zks5tsvS211kqLxfZesslkiWSTJZse-u9d0EMP8mDeY_hm4CH0SMksd4V4Xn-strM9I4yV5ApNKBVVJogori_yLbobhm9COOeUTVB8tbL1YUhW4VqpU5TqjIPBe4inDi-kUzYFbz1egYfsC5xMoPEO-mQ1YOk1rvvgbB_6GBKM3BKPY2vbKK2HF1zjXQRnO-tlPON9OunzPbox0g3w8OdTdHhbHhbv2eZztV7Um6zlgmdSzGnOJZDGyKYoiGFQwbzktKQkZ4pxY1ijiFKGM610YVTT5FQY3cyhqqRkU_T0-7aVDo7Wm5DGcp0d1LHmZVWSUXykZv9QozR0VgUPxo77i4MfQj1s7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study</title><source>Taylor & Francis Open Access</source><source>DOVE Medical Press Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Latif, Rabia ; Rafique, Nazish ; Asoom, Lubna Al ; Alsunni, Ahmed A ; Salem, Ayad Mohammed ; AINoaimi, Dinah Abdulhadi ; AlHarbi, Wasan Mohammed ; Shaikh, Ahad Yasir ; AIRaddadi, Shoug Abdullah ; AIMuhaish, Leena Abdulrahman ; Almohazey, Dana ; Abdulazeez, Sayed ; Borgio, J. Francis</creator><creatorcontrib>Latif, Rabia ; Rafique, Nazish ; Asoom, Lubna Al ; Alsunni, Ahmed A ; Salem, Ayad Mohammed ; AINoaimi, Dinah Abdulhadi ; AlHarbi, Wasan Mohammed ; Shaikh, Ahad Yasir ; AIRaddadi, Shoug Abdullah ; AIMuhaish, Leena Abdulrahman ; Almohazey, Dana ; Abdulazeez, Sayed ; Borgio, J. Francis</creatorcontrib><description>Background: A reliable, migraine-specific biomarker has not been identified so far. Calcitonin Gene-Related Peptide (CGRP) and Apolipoprotein E (ApoE) might serve as migraine biomarkers due to their roles in migraine pathophysiology. However, their diagnostic usefulness has not been explored yet. Present study explored the diagnostic accuracy of CGRP and ApoE in migraine. Methods: A cross-sectional, case-control study was conducted from November 2019 to April 2020 at Physiology department of our university. Fourteen female migraine patients, 18-25 years old, with confirmed "Migraine" diagnosis by a neurologist, were recruited. Control group consisted of 14 age-matched healthy females with no personal/family history of migraine. Blood was drawn once from control subjects and twice from migraine patients (ictal and interictal phase). Serum CGRP and ApoE levels were assessed by ELISA. Statistical analysis involved paired f-test, one-way ANOVA, Receiver operating characteristic (ROC) curves and cross-tabs. Results: ApoE (mg/dl) was higher significantly in interictal (1.90[+ or -]0.50) and ictal (1.97[+ or -]0.65) phases of migraine compared to control (1.07[+ or -]0.26) (p < 0.001). ROC curves for ApoE were significant in migraine ictal vs control (AUC= 0.91, AUC 95% CI: 0.78-1.0) and migraine interictal vs control (AUC=0.92, AUC 95% CI: 0.8-1.0) subjects. ROC curve for CGRP (pg/mL) was significant in migraine ictal vs control subjects only (AUC=0.79, AUC 95% CI: 0.6-0.97). Conclusion: Serum ApoE has "excellent" accuracy to diagnose migraine patients whether in ictal or interictal phase, from healthy subjects. ApoE levels of patients in these two phases of migraine are raised significantly than healthy subjects. CGRP has "fair" diagnostic accuracy to discriminate between migraine ictal phase and healthy subjects. Its levels do not differ significantly among migraine ictal, interictal phase and healthy controls. Keywords: apolipoprotein E, calcitonin gene-related peptide, migraine, receiver operating curve, biomarkers</description><identifier>ISSN: 1178-7074</identifier><identifier>EISSN: 1178-7074</identifier><identifier>DOI: 10.2l47/IJGM.S303350</identifier><language>eng</language><publisher>Dove Medical Press Limited</publisher><subject>Apolipoproteins ; Calcitonin ; Enzyme-linked immunosorbent assay ; Ethylenediaminetetraacetic acid ; Genes ; Genetic research ; Migraine ; Peptides ; Physiological aspects</subject><ispartof>International journal of general medicine, 2021-03, Vol.14, p.851</ispartof><rights>COPYRIGHT 2021 Dove Medical Press Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Latif, Rabia</creatorcontrib><creatorcontrib>Rafique, Nazish</creatorcontrib><creatorcontrib>Asoom, Lubna Al</creatorcontrib><creatorcontrib>Alsunni, Ahmed A</creatorcontrib><creatorcontrib>Salem, Ayad Mohammed</creatorcontrib><creatorcontrib>AINoaimi, Dinah Abdulhadi</creatorcontrib><creatorcontrib>AlHarbi, Wasan Mohammed</creatorcontrib><creatorcontrib>Shaikh, Ahad Yasir</creatorcontrib><creatorcontrib>AIRaddadi, Shoug Abdullah</creatorcontrib><creatorcontrib>AIMuhaish, Leena Abdulrahman</creatorcontrib><creatorcontrib>Almohazey, Dana</creatorcontrib><creatorcontrib>Abdulazeez, Sayed</creatorcontrib><creatorcontrib>Borgio, J. Francis</creatorcontrib><title>Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study</title><title>International journal of general medicine</title><description>Background: A reliable, migraine-specific biomarker has not been identified so far. Calcitonin Gene-Related Peptide (CGRP) and Apolipoprotein E (ApoE) might serve as migraine biomarkers due to their roles in migraine pathophysiology. However, their diagnostic usefulness has not been explored yet. Present study explored the diagnostic accuracy of CGRP and ApoE in migraine. Methods: A cross-sectional, case-control study was conducted from November 2019 to April 2020 at Physiology department of our university. Fourteen female migraine patients, 18-25 years old, with confirmed "Migraine" diagnosis by a neurologist, were recruited. Control group consisted of 14 age-matched healthy females with no personal/family history of migraine. Blood was drawn once from control subjects and twice from migraine patients (ictal and interictal phase). Serum CGRP and ApoE levels were assessed by ELISA. Statistical analysis involved paired f-test, one-way ANOVA, Receiver operating characteristic (ROC) curves and cross-tabs. Results: ApoE (mg/dl) was higher significantly in interictal (1.90[+ or -]0.50) and ictal (1.97[+ or -]0.65) phases of migraine compared to control (1.07[+ or -]0.26) (p < 0.001). ROC curves for ApoE were significant in migraine ictal vs control (AUC= 0.91, AUC 95% CI: 0.78-1.0) and migraine interictal vs control (AUC=0.92, AUC 95% CI: 0.8-1.0) subjects. ROC curve for CGRP (pg/mL) was significant in migraine ictal vs control subjects only (AUC=0.79, AUC 95% CI: 0.6-0.97). Conclusion: Serum ApoE has "excellent" accuracy to diagnose migraine patients whether in ictal or interictal phase, from healthy subjects. ApoE levels of patients in these two phases of migraine are raised significantly than healthy subjects. CGRP has "fair" diagnostic accuracy to discriminate between migraine ictal phase and healthy subjects. Its levels do not differ significantly among migraine ictal, interictal phase and healthy controls. Keywords: apolipoprotein E, calcitonin gene-related peptide, migraine, receiver operating curve, biomarkers</description><subject>Apolipoproteins</subject><subject>Calcitonin</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Genes</subject><subject>Genetic research</subject><subject>Migraine</subject><subject>Peptides</subject><subject>Physiological aspects</subject><issn>1178-7074</issn><issn>1178-7074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj0FLAzEQhYMoWKs3f0DA89Zks5tsvS211kqLxfZesslkiWSTJZse-u9d0EMP8mDeY_hm4CH0SMksd4V4Xn-strM9I4yV5ApNKBVVJogori_yLbobhm9COOeUTVB8tbL1YUhW4VqpU5TqjIPBe4inDi-kUzYFbz1egYfsC5xMoPEO-mQ1YOk1rvvgbB_6GBKM3BKPY2vbKK2HF1zjXQRnO-tlPON9OunzPbox0g3w8OdTdHhbHhbv2eZztV7Um6zlgmdSzGnOJZDGyKYoiGFQwbzktKQkZ4pxY1ijiFKGM610YVTT5FQY3cyhqqRkU_T0-7aVDo7Wm5DGcp0d1LHmZVWSUXykZv9QozR0VgUPxo77i4MfQj1s7A</recordid><startdate>20210331</startdate><enddate>20210331</enddate><creator>Latif, Rabia</creator><creator>Rafique, Nazish</creator><creator>Asoom, Lubna Al</creator><creator>Alsunni, Ahmed A</creator><creator>Salem, Ayad Mohammed</creator><creator>AINoaimi, Dinah Abdulhadi</creator><creator>AlHarbi, Wasan Mohammed</creator><creator>Shaikh, Ahad Yasir</creator><creator>AIRaddadi, Shoug Abdullah</creator><creator>AIMuhaish, Leena Abdulrahman</creator><creator>Almohazey, Dana</creator><creator>Abdulazeez, Sayed</creator><creator>Borgio, J. Francis</creator><general>Dove Medical Press Limited</general><scope/></search><sort><creationdate>20210331</creationdate><title>Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study</title><author>Latif, Rabia ; Rafique, Nazish ; Asoom, Lubna Al ; Alsunni, Ahmed A ; Salem, Ayad Mohammed ; AINoaimi, Dinah Abdulhadi ; AlHarbi, Wasan Mohammed ; Shaikh, Ahad Yasir ; AIRaddadi, Shoug Abdullah ; AIMuhaish, Leena Abdulrahman ; Almohazey, Dana ; Abdulazeez, Sayed ; Borgio, J. Francis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g676-a79126ae0bfab440f3e8e956151023c36ff3bc0ccf63dcd4fcbb217fdb9e88aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apolipoproteins</topic><topic>Calcitonin</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Genes</topic><topic>Genetic research</topic><topic>Migraine</topic><topic>Peptides</topic><topic>Physiological aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Latif, Rabia</creatorcontrib><creatorcontrib>Rafique, Nazish</creatorcontrib><creatorcontrib>Asoom, Lubna Al</creatorcontrib><creatorcontrib>Alsunni, Ahmed A</creatorcontrib><creatorcontrib>Salem, Ayad Mohammed</creatorcontrib><creatorcontrib>AINoaimi, Dinah Abdulhadi</creatorcontrib><creatorcontrib>AlHarbi, Wasan Mohammed</creatorcontrib><creatorcontrib>Shaikh, Ahad Yasir</creatorcontrib><creatorcontrib>AIRaddadi, Shoug Abdullah</creatorcontrib><creatorcontrib>AIMuhaish, Leena Abdulrahman</creatorcontrib><creatorcontrib>Almohazey, Dana</creatorcontrib><creatorcontrib>Abdulazeez, Sayed</creatorcontrib><creatorcontrib>Borgio, J. Francis</creatorcontrib><jtitle>International journal of general medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Latif, Rabia</au><au>Rafique, Nazish</au><au>Asoom, Lubna Al</au><au>Alsunni, Ahmed A</au><au>Salem, Ayad Mohammed</au><au>AINoaimi, Dinah Abdulhadi</au><au>AlHarbi, Wasan Mohammed</au><au>Shaikh, Ahad Yasir</au><au>AIRaddadi, Shoug Abdullah</au><au>AIMuhaish, Leena Abdulrahman</au><au>Almohazey, Dana</au><au>Abdulazeez, Sayed</au><au>Borgio, J. Francis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study</atitle><jtitle>International journal of general medicine</jtitle><date>2021-03-31</date><risdate>2021</risdate><volume>14</volume><spage>851</spage><pages>851-</pages><issn>1178-7074</issn><eissn>1178-7074</eissn><abstract>Background: A reliable, migraine-specific biomarker has not been identified so far. Calcitonin Gene-Related Peptide (CGRP) and Apolipoprotein E (ApoE) might serve as migraine biomarkers due to their roles in migraine pathophysiology. However, their diagnostic usefulness has not been explored yet. Present study explored the diagnostic accuracy of CGRP and ApoE in migraine. Methods: A cross-sectional, case-control study was conducted from November 2019 to April 2020 at Physiology department of our university. Fourteen female migraine patients, 18-25 years old, with confirmed "Migraine" diagnosis by a neurologist, were recruited. Control group consisted of 14 age-matched healthy females with no personal/family history of migraine. Blood was drawn once from control subjects and twice from migraine patients (ictal and interictal phase). Serum CGRP and ApoE levels were assessed by ELISA. Statistical analysis involved paired f-test, one-way ANOVA, Receiver operating characteristic (ROC) curves and cross-tabs. Results: ApoE (mg/dl) was higher significantly in interictal (1.90[+ or -]0.50) and ictal (1.97[+ or -]0.65) phases of migraine compared to control (1.07[+ or -]0.26) (p < 0.001). ROC curves for ApoE were significant in migraine ictal vs control (AUC= 0.91, AUC 95% CI: 0.78-1.0) and migraine interictal vs control (AUC=0.92, AUC 95% CI: 0.8-1.0) subjects. ROC curve for CGRP (pg/mL) was significant in migraine ictal vs control subjects only (AUC=0.79, AUC 95% CI: 0.6-0.97). Conclusion: Serum ApoE has "excellent" accuracy to diagnose migraine patients whether in ictal or interictal phase, from healthy subjects. ApoE levels of patients in these two phases of migraine are raised significantly than healthy subjects. CGRP has "fair" diagnostic accuracy to discriminate between migraine ictal phase and healthy subjects. Its levels do not differ significantly among migraine ictal, interictal phase and healthy controls. Keywords: apolipoprotein E, calcitonin gene-related peptide, migraine, receiver operating curve, biomarkers</abstract><pub>Dove Medical Press Limited</pub><doi>10.2l47/IJGM.S303350</doi></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Apolipoproteins Calcitonin Enzyme-linked immunosorbent assay Ethylenediaminetetraacetic acid Genes Genetic research Migraine Peptides Physiological aspects |
| title | Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study |
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