Alum-adjuvanted protein administered in combination with ALVAC-HIV downregulates early serum cytokine responses to the vaccine whereas MF59 enhances the early cytokine burst

Background: Vaccine adjuvants are detected by the innate immune system and influence adaptive immune responses. The modestly efficacious RV144 Thai trial used alum to adjuvant the gp120 protein boost, whereas the non-efficacious HVTN 702 South African trial used MF59. Volunteers enrolled in HVTN 107...

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Veröffentlicht in:	Journal of the International AIDS Society 2021-01, Vol.24 (S1), p.44
Hauptverfasser:	Nissen, E. Andersen, Voillet, V, Naidoo, A, Kee, J, Gartland, A. Fiore, Dintwe, O, Grunenberg, N, Polakowski, L, Fleurs, L, Jani, I, Sebe, M, Laher, F, Chibanda, L. Stranix, Naicker, N, Mngadi, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Pharmaceutic Genetic aspects Health aspects HIV infection Immune response Prevention Testing Viral proteins
Online-Zugang:	Volltext
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