Pharmacokinetics of Intravenously and Intraperitoneally Administered Mafedine Sodium in Mice
Peculiarities of the pharmacokinetics of mafedine sodium salt upon intraperitoneal (i.p.) and intravenous (i.v.) administration to laboratory mice were studied. A high-performance liquid chromatography (HPLC) method for its quantitative determination was proposed. Mafedine sodium salt was found to h...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2021-03, Vol.54 (12), p.1193-1197 |
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| container_issue | 12 |
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| container_title | Pharmaceutical chemistry journal |
| container_volume | 54 |
| creator | Sysoev, Yu. I. Whaley, A. K. Prikhodko, V. A. Semivelichenko, E. D. Eletskaya, E. I. Luzhanin, V. G. Okovityi, S. V. |
| description | Peculiarities of the pharmacokinetics of mafedine sodium salt upon intraperitoneal (i.p.) and intravenous (i.v.) administration to laboratory mice were studied. A high-performance liquid chromatography (HPLC) method for its quantitative determination was proposed. Mafedine sodium salt was found to have a short biological elimination half-life after both i.p. and i.v. administration (15.73 and 6.98 min, respectively) and high i.p. bioavailability (~94%). Features of the alpha-2-adrenomimetic activity of mafedine sodium salt could be elucidated by further searches for and investigations of its metabolites and their pharmacokinetics. |
| doi_str_mv | 10.1007/s11094-021-02342-y |
| format | Article |
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Features of the alpha-2-adrenomimetic activity of mafedine sodium salt could be elucidated by further searches for and investigations of its metabolites and their pharmacokinetics.</description><subject>Dexmedetomidine</subject><subject>High performance liquid chromatography</subject><subject>Medicine</subject><subject>Mice</subject><subject>Molecular-Biological Problems of Drug Design and Mechanism of Drug Action</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kFtLAzEQhYMoWKt_wKcFn1dnNsleHkvxUmhRUMEHIaRJtqbuZkuyFfbfG11fBJFhGDicb5g5hJwjXCJAcRUQoWIpZBibsiwdDsgEeUHTCigekglAhSlyeDkmJyFsASJGswl5fXiTvpWqe7fO9FaFpKuTheu9_DCu24dmSKTTo7Iz3vadM7KJ6ky31tnQG290spK10XFB8thpu28T65KVVeaUHNWyCebsZ07J88310_wuXd7fLuazZaooL_s0K7Ic1iVUWnHFKOdGSVlmyBRUgAqxKOscmMKs4AaqQldSMlaxfI2aKV7TKbkY925kY4R1dRevVa0NSsxyniPmBeXRdfmHK5Y2rVXxr9pG_ReQjYDyXQje1GLnbSv9IBDEV-xijF3E2MV37GKIEB2hEM1uY7zYdnvv4vv_UZ-Z24Vu</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Sysoev, Yu. 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V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of Intravenously and Intraperitoneally Administered Mafedine Sodium in Mice</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2021-03-01</date><risdate>2021</risdate><volume>54</volume><issue>12</issue><spage>1193</spage><epage>1197</epage><pages>1193-1197</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>Peculiarities of the pharmacokinetics of mafedine sodium salt upon intraperitoneal (i.p.) and intravenous (i.v.) administration to laboratory mice were studied. A high-performance liquid chromatography (HPLC) method for its quantitative determination was proposed. Mafedine sodium salt was found to have a short biological elimination half-life after both i.p. and i.v. administration (15.73 and 6.98 min, respectively) and high i.p. bioavailability (~94%). 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| subjects | Dexmedetomidine High performance liquid chromatography Medicine Mice Molecular-Biological Problems of Drug Design and Mechanism of Drug Action Organic Chemistry Pharmacology/Toxicology Pharmacy |
| title | Pharmacokinetics of Intravenously and Intraperitoneally Administered Mafedine Sodium in Mice |
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