A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor (HER2)-targeted therapies is frequently associated with HER3 and active signaling via HER2-HER3 dimers, particularly in the context of breast cancer. Thus, understanding the response to HER2-HER3 signaling a...

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Veröffentlicht in:	Oncogene 2021-02, Vol.40 (7), p.1300-1317
Hauptverfasser:	Al-Akhrass, Hussein, Conway, James R. W., Poulsen, Annemarie Svane Aavild, Paatero, Ilkka, Kaivola, Jasmin, Padzik, Artur, Andersen, Olav M., Ivaska, Johanna
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/19 631/67/1347 631/80/86/2368 64/116 82/103 96/109 96/35 Animals Apoptosis Biochemistry & Molecular Biology Brain - drug effects Brain - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Care and treatment Cell Biology Cell proliferation Cell Proliferation - drug effects Cell surface Development and progression Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epidermal growth factor ErbB-2 protein Female Gene expression Genetic aspects Genetics & Heredity Health aspects Heregulin Heterografts Human Genetics Humans Internal Medicine Kinases LDL-Receptor Related Proteins - genetics Life Sciences & Biomedicine Lysosomes MAP kinase Medicine Medicine & Public Health Membrane Transport Proteins - genetics Metastases Mice Neuregulin-1 - pharmacology Oncology Protein-tyrosine kinase Protein-tyrosine kinase receptors rab4 GTP-Binding Proteins - genetics Receptor, ErbB-2 - genetics Receptor, ErbB-3 - genetics Science & Technology Spheroids Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Transcription Xenografts Zebrafish
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