MSC-induced lncRNA AGAP2-AS1 promotes stemness and trastuzumab resistance through regulating CPT1 expression and fatty acid oxidation in breast cancer

Trastuzumab resistance has been becoming a major obstacle for treatment of HER-2-positive breast cancer patients. Increasing evidence suggests that mesenchymal stem cells (MSCs) play critical roles during the formation of drug resistance, however, the underlying mechanism is not well known. In this...

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Veröffentlicht in:	Oncogene 2021-01, Vol.40 (4), p.833
Hauptverfasser:	Han, Jing, Qu, Hongbo, Han, Mingli, Ding, Yichao, Xie, Mingwei, Hu, Jianguo, Chen, Yuanwen, Dong, Huaying
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cancer cells Care and treatment Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - physiology Cell Line, Tumor Development and progression Drug Resistance, Neoplasm ELAV-Like Protein 1 - physiology Fatty Acids - metabolism Female Gene expression Genetic aspects Health aspects Humans Mesenchymal Stem Cells - physiology MicroRNAs - physiology Oxidation-Reduction RNA RNA, Long Noncoding - physiology Stem cells Trastuzumab - therapeutic use
Online-Zugang:	Volltext
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