Mixed phenotype acute leukemia with PML-RAR[alpha] positive: a case report and literature review
Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as...
Gespeichert in:
| Veröffentlicht in: | Molecular cytogenetics 2021-02, Vol.14 (1) |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | |
| container_title | Molecular cytogenetics |
| container_volume | 14 |
| creator | Zheng, Xiaolong Shen, Huafei Zhu, Mingyu Shi, Yuanfei Wang, Huanping Chen, Zhimei Huang, Xin Wang, Yungui Jin, Jie Xie, Wanzhuo |
| description | Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RAR[alpha] positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients. Keywords: Acute leukemia, T/myeloid subtype, Mixed phenotype acute leukemia, PML-RAR[alpha], t(15;17), Acute biphenotypic leukemia, Case report |
| doi_str_mv | 10.1186/s13039-021-00530-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A653583769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A653583769</galeid><sourcerecordid>A653583769</sourcerecordid><originalsourceid>FETCH-LOGICAL-g679-cfde79f1a9f6967508ecc6b9d3068f6b02ba718fe5704f7cfdbc87732b97e2993</originalsourceid><addsrcrecordid>eNptj01LAzEQhoMoWKt_wFPAc2qyab68laJVaFFKbyI1m5200e3usklb_fdu0UMPMod3eHhm4EXomtEBY1reRsYpN4RmjFAqOCXmBPWYEoJoJuXp0X6OLmL8oFQyroc99D4LX1DgZg1Vnb4bwNZtE-AStp-wCRbvQ1rjl9mUzEfzV1s2a_uGmzqGFHZwhy12NgJuoanbhG1V4DIkaG3atge6C7C_RGfelhGu_rKPFg_3i_EjmT5PnsajKVlJZYjzBSjjmTVeGqkE1eCczE3BqdRe5jTLrWLag1B06FWn504rxbPcKMiM4X108_t2ZUtYhsrXqbVuE6JbjqTgQnMlD9bgH6uboivr6gp86PjRwQ8VWGb5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Mixed phenotype acute leukemia with PML-RAR[alpha] positive: a case report and literature review</title><source>DOAJ Directory of Open Access Journals</source><source>SpringerNature Complete Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Zheng, Xiaolong ; Shen, Huafei ; Zhu, Mingyu ; Shi, Yuanfei ; Wang, Huanping ; Chen, Zhimei ; Huang, Xin ; Wang, Yungui ; Jin, Jie ; Xie, Wanzhuo</creator><creatorcontrib>Zheng, Xiaolong ; Shen, Huafei ; Zhu, Mingyu ; Shi, Yuanfei ; Wang, Huanping ; Chen, Zhimei ; Huang, Xin ; Wang, Yungui ; Jin, Jie ; Xie, Wanzhuo</creatorcontrib><description>Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RAR[alpha] positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients. Keywords: Acute leukemia, T/myeloid subtype, Mixed phenotype acute leukemia, PML-RAR[alpha], t(15;17), Acute biphenotypic leukemia, Case report</description><identifier>ISSN: 1755-8166</identifier><identifier>EISSN: 1755-8166</identifier><identifier>DOI: 10.1186/s13039-021-00530-9</identifier><language>eng</language><publisher>BioMed Central Ltd</publisher><subject>Acute leukemia ; Anthracyclines ; Cancer ; Chemotherapy ; Diagnosis ; Genetic aspects ; Prognosis ; Vincristine</subject><ispartof>Molecular cytogenetics, 2021-02, Vol.14 (1)</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Zheng, Xiaolong</creatorcontrib><creatorcontrib>Shen, Huafei</creatorcontrib><creatorcontrib>Zhu, Mingyu</creatorcontrib><creatorcontrib>Shi, Yuanfei</creatorcontrib><creatorcontrib>Wang, Huanping</creatorcontrib><creatorcontrib>Chen, Zhimei</creatorcontrib><creatorcontrib>Huang, Xin</creatorcontrib><creatorcontrib>Wang, Yungui</creatorcontrib><creatorcontrib>Jin, Jie</creatorcontrib><creatorcontrib>Xie, Wanzhuo</creatorcontrib><title>Mixed phenotype acute leukemia with PML-RAR[alpha] positive: a case report and literature review</title><title>Molecular cytogenetics</title><description>Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RAR[alpha] positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients. Keywords: Acute leukemia, T/myeloid subtype, Mixed phenotype acute leukemia, PML-RAR[alpha], t(15;17), Acute biphenotypic leukemia, Case report</description><subject>Acute leukemia</subject><subject>Anthracyclines</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Genetic aspects</subject><subject>Prognosis</subject><subject>Vincristine</subject><issn>1755-8166</issn><issn>1755-8166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj01LAzEQhoMoWKt_wFPAc2qyab68laJVaFFKbyI1m5200e3usklb_fdu0UMPMod3eHhm4EXomtEBY1reRsYpN4RmjFAqOCXmBPWYEoJoJuXp0X6OLmL8oFQyroc99D4LX1DgZg1Vnb4bwNZtE-AStp-wCRbvQ1rjl9mUzEfzV1s2a_uGmzqGFHZwhy12NgJuoanbhG1V4DIkaG3atge6C7C_RGfelhGu_rKPFg_3i_EjmT5PnsajKVlJZYjzBSjjmTVeGqkE1eCczE3BqdRe5jTLrWLag1B06FWn504rxbPcKMiM4X108_t2ZUtYhsrXqbVuE6JbjqTgQnMlD9bgH6uboivr6gp86PjRwQ8VWGb5</recordid><startdate>20210211</startdate><enddate>20210211</enddate><creator>Zheng, Xiaolong</creator><creator>Shen, Huafei</creator><creator>Zhu, Mingyu</creator><creator>Shi, Yuanfei</creator><creator>Wang, Huanping</creator><creator>Chen, Zhimei</creator><creator>Huang, Xin</creator><creator>Wang, Yungui</creator><creator>Jin, Jie</creator><creator>Xie, Wanzhuo</creator><general>BioMed Central Ltd</general><scope/></search><sort><creationdate>20210211</creationdate><title>Mixed phenotype acute leukemia with PML-RAR[alpha] positive: a case report and literature review</title><author>Zheng, Xiaolong ; Shen, Huafei ; Zhu, Mingyu ; Shi, Yuanfei ; Wang, Huanping ; Chen, Zhimei ; Huang, Xin ; Wang, Yungui ; Jin, Jie ; Xie, Wanzhuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g679-cfde79f1a9f6967508ecc6b9d3068f6b02ba718fe5704f7cfdbc87732b97e2993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute leukemia</topic><topic>Anthracyclines</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Diagnosis</topic><topic>Genetic aspects</topic><topic>Prognosis</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Xiaolong</creatorcontrib><creatorcontrib>Shen, Huafei</creatorcontrib><creatorcontrib>Zhu, Mingyu</creatorcontrib><creatorcontrib>Shi, Yuanfei</creatorcontrib><creatorcontrib>Wang, Huanping</creatorcontrib><creatorcontrib>Chen, Zhimei</creatorcontrib><creatorcontrib>Huang, Xin</creatorcontrib><creatorcontrib>Wang, Yungui</creatorcontrib><creatorcontrib>Jin, Jie</creatorcontrib><creatorcontrib>Xie, Wanzhuo</creatorcontrib><jtitle>Molecular cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Xiaolong</au><au>Shen, Huafei</au><au>Zhu, Mingyu</au><au>Shi, Yuanfei</au><au>Wang, Huanping</au><au>Chen, Zhimei</au><au>Huang, Xin</au><au>Wang, Yungui</au><au>Jin, Jie</au><au>Xie, Wanzhuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed phenotype acute leukemia with PML-RAR[alpha] positive: a case report and literature review</atitle><jtitle>Molecular cytogenetics</jtitle><date>2021-02-11</date><risdate>2021</risdate><volume>14</volume><issue>1</issue><issn>1755-8166</issn><eissn>1755-8166</eissn><abstract>Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RAR[alpha] positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients. Keywords: Acute leukemia, T/myeloid subtype, Mixed phenotype acute leukemia, PML-RAR[alpha], t(15;17), Acute biphenotypic leukemia, Case report</abstract><pub>BioMed Central Ltd</pub><doi>10.1186/s13039-021-00530-9</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1755-8166 |
| ispartof | Molecular cytogenetics, 2021-02, Vol.14 (1) |
| issn | 1755-8166 1755-8166 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A653583769 |
| source | DOAJ Directory of Open Access Journals; SpringerNature Complete Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acute leukemia Anthracyclines Cancer Chemotherapy Diagnosis Genetic aspects Prognosis Vincristine |
| title | Mixed phenotype acute leukemia with PML-RAR[alpha] positive: a case report and literature review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T14%3A39%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mixed%20phenotype%20acute%20leukemia%20with%20PML-RAR%5Balpha%5D%20positive:%20a%20case%20report%20and%20literature%20review&rft.jtitle=Molecular%20cytogenetics&rft.au=Zheng,%20Xiaolong&rft.date=2021-02-11&rft.volume=14&rft.issue=1&rft.issn=1755-8166&rft.eissn=1755-8166&rft_id=info:doi/10.1186/s13039-021-00530-9&rft_dat=%3Cgale%3EA653583769%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A653583769&rfr_iscdi=true |