NEW APPROACHES TO EXPLAINING THE ETIOLOGY IN RECURRENT PREGNANCY LOSSES/TEKRARLAYAN GEBELIK KAYIPLARINDA ETIYOLOJININ ACIKLANMASINA YONELIK YENI YAKLASIMLAR

Recurrent pregnancy losses are seen in approximately 1-3% of the world's pregnancies and it has been a subject that has been studied for years. Pregnancy includes the production of fertile cells, fertilization, implantation, embryological development processes, the formation of the placenta, the provision of feto-maternal blood circulation and the continuity of pregnancy. Factors affecting an associated pathway in any of these processes may be the underlying cause of pregnancy loss. With the new technologies, it has started to be shown that genetic factors in etiology in pregnancy losses are not only chromosome anomalies, but also single-gene mutations or different genetic factors. The identification of new gene/s and the understanding of the activity of the pathways are compelling enough to change the diagnosis and treatment approaches in the unexplained cases group. Keywords: Recurrent pregnancy loss, next generation sequencing, genetics Tekrarlayan gebelik kayiplari tum dunyada yaklasik %1-3 oraninda gorulmekte olup, yillardir uzerinde calisilan bir konudur. Gebelik, ureme hucrelerinin uretiminden baslayarak, fertilizasyon, implantasyon, embriyolojik gelisim surecleri, plasentanin olusumu, feto-maternal kan dolasiminin saglanmasi ve gebelisin devamini kapsayan oldukca genis ve farkli surecleri icermektedir. Bu sureclerden herhangi birinde, iliskili bir yolagi etkileyen faktorler gebelik kayiplarinda altta yatan sebep olabilir. Yeni teknolojiler ile birlikte gebelik kayiplarinda etiyolojide yer alan genetik faktorlerin sadece kromozom anomalileri degil, tek gen mutasyonlari ya da farkli genetik faktorlerin de oldugu gosterilmektedir. Yeni gen/lerin tanimlanmasi ve yolaklarin aktivitesinin anlasilmasi sebebi aciklanamayan olgu grubunda tani ve tedavi yaklasimlarini degistirebilecek guctedir. Anahtar Kelimeler: Tekrarlayan gebelik kayiplari, yeni nesil dizileme, genetik