Nogo-66 promotes [beta]-amyloid protein secretion via NgR/ROCK-dependent BACE1 activation

The generation of [beta]-amyloid protein (A[beta]) is considered a key step in the pathogenesis of Alzheimer's disease (AD) and the regulation of its production is an important therapeutic strategy. It was hypothesized in the present study that Nogo-A may be involved in AD and may regulate the...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular medicine reports 2021-03, Vol.23 (3)
Hauptverfasser:	Xie, Qing-qing, Feng, Xiao, Huang, Yi-yun, Fang, Nian, Yi, Hua, Wang, Zi-jian, Cao, Qiao-yu, Lou, Guo-feng, Pan, Jun-ping, Hu, Yang, Li, Fang-cheng, Zheng, Qing, Xiao, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-protein Care and treatment Cellular signal transduction Development and progression Gene expression Genetic aspects Health aspects Nervous system Regeneration
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!