Praziquantel Efficacy Increased Using Mechanical Technology and Supramolecular Targeted Delivery System for Treatment of Cestodiasis

Various samples of praziquantel (PZQ) with polyvinylpyrrolidone (PVP) and sodium dioctyl sulfosuccinate (SDS) with increased aqueous solubility and efficacy against the cestodes Hymenolepis nana and Moniezia expansa were obtained using mechanochemical technology. The anthelmintic activity of the obtained samples of PZQ supramolecular complexes was studied on a laboratory model of hymenolepiasis in white mice and sheep naturally infected with M. expansa using results of helmintological necropsy of the small intestines and taking into account the number of detected cestodes. The supramolecular complex of PZQ with PVP and SDS in a 10:89:1 ratio at doses of 3, 2, and 1 mg of active compound per kg of body mass were highly efficacious (>97%) against H. nana and M. expansa . In contrast, PZQ substance and a mechanical mixture of PZQ with PVP and SDS at a dose of 1 mg of PZQ per kg showed weak efficacy. The supramolecular complex of PZQ turned out to be a promising anthelmintic drug with increased pharmacological activity.