Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP.sup.+ in dissociated cultures from rat mesencephalon

Parkinson's disease is associated with the loss of dopamine (DA) neurons in ventral mesencephalon. We have previously reported that no single neurotrophic factor we tested protected DA neurons from the dopaminergic toxin 1-methyl-4-phenylpyridinium (MPP.sup.+) in dissociated cultures isolated f...

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Veröffentlicht in:	PloS one 2021-02, Vol.16 (2), p.e0245663
Hauptverfasser:	Jaumotte, Juliann D, Saarma, Mart, Zigmond, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Dopamine Drug therapy Health aspects Mesencephalon Neurological research Neurons Neuroprotective agents Neurotrophic functions Parkinson's disease Physiological aspects
Online-Zugang:	Volltext
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