Ins1-Cre and [Ins1-Cre.sup.ER] Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation

Targeted gene ablation studies of the endocrine pancreas have long suffered from suboptimal Cre deleter strains. In many cases, Cre lines purportedly specific for beta cells also displayed expression in other islet endocrine cells or in a subset of neurons in the brain. Several pancreas and endocrin...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2020-08, Vol.161 (8), p.1
Hauptverfasser:	Mosleh, Elham, Ou, Kristy, Haemmerle, Matthew W, Tembo, Teguru, Yuhas, Andrew, Carboneau, Bethany A, Townsend, Shannon E, Bosma, Karin J, Gannon, Maureen, O'Brien, Richard M, Stoffers, Doris A, Golson, Maria L
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene expression Gene silencing Genetic aspects Genetic engineering Genetic research Health aspects Pancreatic beta cells
Online-Zugang:	Volltext
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