Glomerular C4d deposition in proliferative glomerular diseases
Introduction: The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and clinicopathological parameters, other complemen...
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| Veröffentlicht in: | Indian journal of pathology & microbiology 2021-01, Vol.64 (1), p.69-77 |
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| description | Introduction: The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and clinicopathological parameters, other complement proteins, and immunoglobulin markers. Methods: This cross-sectional study was conducted during the year 2018-19 involving 107 native renal biopsies with histologically diagnosed cases of proliferative glomerular diseases. C4d immunohistochemical evaluation of renal tissue sections was performed using polyclonal antihuman C4d as the primary antibody. Patients were classified as positive and negative groups based on their glomerular C4d deposition. Results: The overall prevalence of C4d positivity was 80.4% in proliferative glomerular diseases ranging between 60.0% in C3 glomerulonephritis to 92.9% in membranoproliferative glomerulonephritis. Mixed capillary and mesangial deposition were noted in all cases of proliferative glomerulonephritis. Classical pathway was dominantly involved in all glomerular diseases except C3 glomerulonephritis and IgA nephropathy. Multivariate logistic regression analysis revealed that glomerular IgG staining (aOR: 5.86, 95% CI: 1.26-27.14) and IgM staining (aOR: 3.90, 95%CI: 1.07-14.18) were significantly associated with C4d positivity. Conclusion: C4d staining along with immunoglobulin markers such as IgG and IgM and complement proteins can be useful in delineating different complement activation pathways in glomerular diseases and understanding the disease pathogenesis. |
| doi_str_mv | 10.4103/IJPM.IJPM_364_20 |
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Methods: This cross-sectional study was conducted during the year 2018-19 involving 107 native renal biopsies with histologically diagnosed cases of proliferative glomerular diseases. C4d immunohistochemical evaluation of renal tissue sections was performed using polyclonal antihuman C4d as the primary antibody. Patients were classified as positive and negative groups based on their glomerular C4d deposition. Results: The overall prevalence of C4d positivity was 80.4% in proliferative glomerular diseases ranging between 60.0% in C3 glomerulonephritis to 92.9% in membranoproliferative glomerulonephritis. Mixed capillary and mesangial deposition were noted in all cases of proliferative glomerulonephritis. Classical pathway was dominantly involved in all glomerular diseases except C3 glomerulonephritis and IgA nephropathy. Multivariate logistic regression analysis revealed that glomerular IgG staining (aOR: 5.86, 95% CI: 1.26-27.14) and IgM staining (aOR: 3.90, 95%CI: 1.07-14.18) were significantly associated with C4d positivity. Conclusion: C4d staining along with immunoglobulin markers such as IgG and IgM and complement proteins can be useful in delineating different complement activation pathways in glomerular diseases and understanding the disease pathogenesis.</description><identifier>ISSN: 0377-4929</identifier><identifier>EISSN: 0974-5130</identifier><identifier>DOI: 10.4103/IJPM.IJPM_364_20</identifier><identifier>PMID: 33433412</identifier><language>eng</language><publisher>MUMBAI: Wolters Kluwer Medknow Publications</publisher><subject>Adult ; Antibodies ; Biomarkers - analysis ; Biopsy ; c4d positivity ; Classical pathway ; Complement ; Complement activation ; Complement C4 - classification ; Complement C4 - genetics ; Complement C4 - immunology ; Complement component C3 ; complement proteins ; Cross-Sectional Studies ; Deposition ; Disease Progression ; Evaluation ; Female ; Glomerulonephritis ; Glomerulonephritis, Membranoproliferative - diagnosis ; Glomerulonephritis, Membranoproliferative - physiopathology ; Humans ; IgA nephropathy ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; immunoglobulin markers ; Immunoglobulins ; Immunohistochemistry - methods ; Immunohistochemistry - statistics & numerical data ; Kidney - pathology ; Kidney Glomerulus - pathology ; Kidneys ; Life Sciences & Biomedicine ; Male ; Markers ; Medical research ; Medicine, Experimental ; Methenamine ; Middle Aged ; Pathogenesis ; Pathology ; proliferative glomerular disease ; Proliferative kidney disease ; Proteins ; Regression analysis ; renal biopsy ; Retrospective Studies ; Science & Technology ; Staining ; Staining and Labeling ; Viral antibodies</subject><ispartof>Indian journal of pathology & microbiology, 2021-01, Vol.64 (1), p.69-77</ispartof><rights>COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd.</rights><rights>2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000609889300013</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c455t-49f2ed5a21f43995e458e4ac190db742679a4ed202ee24b2049c928aeae022263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,2103,2115,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33433412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raman, Sarojini</creatorcontrib><creatorcontrib>Mishra, Pallavi</creatorcontrib><creatorcontrib>Panigrahi, Ansuman</creatorcontrib><creatorcontrib>Rout, Nikunj K.</creatorcontrib><creatorcontrib>Dash, Kanakalata</creatorcontrib><title>Glomerular C4d deposition in proliferative glomerular diseases</title><title>Indian journal of pathology & microbiology</title><addtitle>INDIAN J PATHOL MICR</addtitle><addtitle>Indian J Pathol Microbiol</addtitle><description>Introduction: The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and clinicopathological parameters, other complement proteins, and immunoglobulin markers. Methods: This cross-sectional study was conducted during the year 2018-19 involving 107 native renal biopsies with histologically diagnosed cases of proliferative glomerular diseases. C4d immunohistochemical evaluation of renal tissue sections was performed using polyclonal antihuman C4d as the primary antibody. Patients were classified as positive and negative groups based on their glomerular C4d deposition. Results: The overall prevalence of C4d positivity was 80.4% in proliferative glomerular diseases ranging between 60.0% in C3 glomerulonephritis to 92.9% in membranoproliferative glomerulonephritis. Mixed capillary and mesangial deposition were noted in all cases of proliferative glomerulonephritis. Classical pathway was dominantly involved in all glomerular diseases except C3 glomerulonephritis and IgA nephropathy. Multivariate logistic regression analysis revealed that glomerular IgG staining (aOR: 5.86, 95% CI: 1.26-27.14) and IgM staining (aOR: 3.90, 95%CI: 1.07-14.18) were significantly associated with C4d positivity. Conclusion: C4d staining along with immunoglobulin markers such as IgG and IgM and complement proteins can be useful in delineating different complement activation pathways in glomerular diseases and understanding the disease pathogenesis.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Biomarkers - analysis</subject><subject>Biopsy</subject><subject>c4d positivity</subject><subject>Classical pathway</subject><subject>Complement</subject><subject>Complement activation</subject><subject>Complement C4 - classification</subject><subject>Complement C4 - genetics</subject><subject>Complement C4 - immunology</subject><subject>Complement component C3</subject><subject>complement proteins</subject><subject>Cross-Sectional Studies</subject><subject>Deposition</subject><subject>Disease Progression</subject><subject>Evaluation</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis, Membranoproliferative - diagnosis</subject><subject>Glomerulonephritis, Membranoproliferative - physiopathology</subject><subject>Humans</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>immunoglobulin markers</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry - methods</subject><subject>Immunohistochemistry - statistics & numerical data</subject><subject>Kidney - pathology</subject><subject>Kidney Glomerulus - pathology</subject><subject>Kidneys</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Markers</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Methenamine</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>proliferative glomerular disease</subject><subject>Proliferative kidney disease</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>renal biopsy</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><subject>Staining</subject><subject>Staining and Labeling</subject><subject>Viral antibodies</subject><issn>0377-4929</issn><issn>0974-5130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk2LFDEQhhtR3HX17kkavAgyY1Kp_shFWBpdR1b0oOeQTipDhu7OmHQr_nszO-usigdJSIrieStVqSqKp5ytkTPxavP-04f14VCiRgXsXnHOZIOrigt2P9uiaVYoQZ4Vj1LaMVYjVOJhcSYE5s3hvHh9NYSR4jLoWHZoS0v7kPzsw1T6qdzHMHhHUc_-G5XbO9T6RDpRelw8cHpI9OT2vii-vH3zuXu3uv54tekur1cGq2rOOTggW2ngDoWUFWHVEmrDJbN9g1A3UiNZYEAE2ANDaSS0mjQxAKjFRbE5xrVB79Q--lHHHypor24cIW6VjrM3AynXCl1ZaRHaHltOvZM9l2ChFzU5NDnWi2OsXN3XhdKsRp8MDYOeKCxJATYN1AAoM_r8L3QXljjlSlX-SKh5hYzfUVud3_eTC3PU5hBUXdbYQpXrEpla_4PKy9LoTZjI-ez_Q8COAhNDSpHcqW7O1KH96qbzv7U_S57d5rv0I9mT4Fe_M9Aege_UB5eMp8nQCWN5QphsWymyxUXnZ32YhC4s05ylL_9fKn4CJwDJNA</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Raman, Sarojini</creator><creator>Mishra, Pallavi</creator><creator>Panigrahi, Ansuman</creator><creator>Rout, Nikunj K.</creator><creator>Dash, Kanakalata</creator><general>Wolters Kluwer Medknow Publications</general><general>Medknow Publications and Media Pvt. 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analysis</topic><topic>Biopsy</topic><topic>c4d positivity</topic><topic>Classical pathway</topic><topic>Complement</topic><topic>Complement activation</topic><topic>Complement C4 - classification</topic><topic>Complement C4 - genetics</topic><topic>Complement C4 - immunology</topic><topic>Complement component C3</topic><topic>complement proteins</topic><topic>Cross-Sectional Studies</topic><topic>Deposition</topic><topic>Disease Progression</topic><topic>Evaluation</topic><topic>Female</topic><topic>Glomerulonephritis</topic><topic>Glomerulonephritis, Membranoproliferative - diagnosis</topic><topic>Glomerulonephritis, Membranoproliferative - physiopathology</topic><topic>Humans</topic><topic>IgA nephropathy</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>immunoglobulin markers</topic><topic>Immunoglobulins</topic><topic>Immunohistochemistry - methods</topic><topic>Immunohistochemistry - statistics & numerical data</topic><topic>Kidney - pathology</topic><topic>Kidney Glomerulus - pathology</topic><topic>Kidneys</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Markers</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Methenamine</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>proliferative glomerular disease</topic><topic>Proliferative kidney disease</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>renal biopsy</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><topic>Staining</topic><topic>Staining and Labeling</topic><topic>Viral antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raman, Sarojini</creatorcontrib><creatorcontrib>Mishra, Pallavi</creatorcontrib><creatorcontrib>Panigrahi, Ansuman</creatorcontrib><creatorcontrib>Rout, Nikunj K.</creatorcontrib><creatorcontrib>Dash, Kanakalata</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - 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Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Indian journal of pathology & microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raman, Sarojini</au><au>Mishra, Pallavi</au><au>Panigrahi, Ansuman</au><au>Rout, Nikunj K.</au><au>Dash, Kanakalata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glomerular C4d deposition in proliferative glomerular diseases</atitle><jtitle>Indian journal of pathology & microbiology</jtitle><stitle>INDIAN J PATHOL MICR</stitle><addtitle>Indian J Pathol Microbiol</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>64</volume><issue>1</issue><spage>69</spage><epage>77</epage><pages>69-77</pages><issn>0377-4929</issn><eissn>0974-5130</eissn><abstract>Introduction: The aim of this study was to evaluate the immunohistochemical expression of C4d in native renal biopsies of proliferative glomerular diseases, complement pathways in these diseases, and assess the relationship of C4d with histological and clinicopathological parameters, other complement proteins, and immunoglobulin markers. Methods: This cross-sectional study was conducted during the year 2018-19 involving 107 native renal biopsies with histologically diagnosed cases of proliferative glomerular diseases. C4d immunohistochemical evaluation of renal tissue sections was performed using polyclonal antihuman C4d as the primary antibody. Patients were classified as positive and negative groups based on their glomerular C4d deposition. Results: The overall prevalence of C4d positivity was 80.4% in proliferative glomerular diseases ranging between 60.0% in C3 glomerulonephritis to 92.9% in membranoproliferative glomerulonephritis. Mixed capillary and mesangial deposition were noted in all cases of proliferative glomerulonephritis. Classical pathway was dominantly involved in all glomerular diseases except C3 glomerulonephritis and IgA nephropathy. Multivariate logistic regression analysis revealed that glomerular IgG staining (aOR: 5.86, 95% CI: 1.26-27.14) and IgM staining (aOR: 3.90, 95%CI: 1.07-14.18) were significantly associated with C4d positivity. Conclusion: C4d staining along with immunoglobulin markers such as IgG and IgM and complement proteins can be useful in delineating different complement activation pathways in glomerular diseases and understanding the disease pathogenesis.</abstract><cop>MUMBAI</cop><pub>Wolters Kluwer Medknow Publications</pub><pmid>33433412</pmid><doi>10.4103/IJPM.IJPM_364_20</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antibodies Biomarkers - analysis Biopsy c4d positivity Classical pathway Complement Complement activation Complement C4 - classification Complement C4 - genetics Complement C4 - immunology Complement component C3 complement proteins Cross-Sectional Studies Deposition Disease Progression Evaluation Female Glomerulonephritis Glomerulonephritis, Membranoproliferative - diagnosis Glomerulonephritis, Membranoproliferative - physiopathology Humans IgA nephropathy Immunoglobulin A Immunoglobulin G Immunoglobulin M immunoglobulin markers Immunoglobulins Immunohistochemistry - methods Immunohistochemistry - statistics & numerical data Kidney - pathology Kidney Glomerulus - pathology Kidneys Life Sciences & Biomedicine Male Markers Medical research Medicine, Experimental Methenamine Middle Aged Pathogenesis Pathology proliferative glomerular disease Proliferative kidney disease Proteins Regression analysis renal biopsy Retrospective Studies Science & Technology Staining Staining and Labeling Viral antibodies |
| title | Glomerular C4d deposition in proliferative glomerular diseases |
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