Dosimetric comparison of modern radiotherapy techniques for gastric cancer after total gastrectomy
Purpose: The purpose of this study is to investigate the optimal radiotherapy technique for postoperative irradiation of gastric cancer treated with total gastrectomy. Materials and Methods: The database of ten patients was used for this study. Three-dimensional (3D) conformal radiotherapy, intensit...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2020-12, Vol.16 (Supplement), p.S133-S137 |
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| creator | Altinok, Pelin Tekce, Ertugrul Karakose, Fatih Berk, Kemal Kalafat, UEmmuehan Kiziltan, Huriye Senay Akgun, Zueleyha Mayadagli, Alpaslan |
| description | Purpose: The purpose of this study is to investigate the optimal radiotherapy technique for postoperative irradiation of gastric cancer treated with total gastrectomy. Materials and Methods: The database of ten patients was used for this study. Three-dimensional (3D) conformal radiotherapy, intensity-modulated therapy (IMRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) plans were created for each dataset. The prescription dose was 45 Gy in 25 fractions. Comparative analyses of the target volume coverage and the doses of organs at risk were performed. Results: HT was significantly provided more homogeneity. The best conformal plans were achieved with VMAT. Both kidneys were better preserved with HT and VMAT. HT significantly lowered the V13 of the left kidney and VMAT significantly lowered V20. However, the mean left kidney doses were not statistically different. The lowest liver V30 was obtained with VMAT but not with statistically different than IMRT and HT. Mean liver doses were statistically inferior with 3D. The worst spinal cord doses were seen with 3D. The integral dose of the body did not differ among the techniques. Conclusion: In comparison of the four techniques, 3D seems to be the most unsuitable method regarding sparing the normal tissues. According to availability, HT and VMAT should be primarily preferred. IMRT can also be used with carefully paying attention to the clinical condition of the patient. |
| doi_str_mv | 10.4103/jcrt.JCRT_548_18 |
| format | Article |
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Materials and Methods: The database of ten patients was used for this study. Three-dimensional (3D) conformal radiotherapy, intensity-modulated therapy (IMRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) plans were created for each dataset. The prescription dose was 45 Gy in 25 fractions. Comparative analyses of the target volume coverage and the doses of organs at risk were performed. Results: HT was significantly provided more homogeneity. The best conformal plans were achieved with VMAT. Both kidneys were better preserved with HT and VMAT. HT significantly lowered the V13 of the left kidney and VMAT significantly lowered V20. However, the mean left kidney doses were not statistically different. The lowest liver V30 was obtained with VMAT but not with statistically different than IMRT and HT. Mean liver doses were statistically inferior with 3D. The worst spinal cord doses were seen with 3D. The integral dose of the body did not differ among the techniques. Conclusion: In comparison of the four techniques, 3D seems to be the most unsuitable method regarding sparing the normal tissues. According to availability, HT and VMAT should be primarily preferred. IMRT can also be used with carefully paying attention to the clinical condition of the patient.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/jcrt.JCRT_548_18</identifier><identifier>PMID: 33380667</identifier><language>eng</language><publisher>MUMBAI: Wolters Kluwer Medknow Publications</publisher><subject>Care and treatment ; Dosimetry ; Gastrectomy ; Gastrectomy - methods ; Gastric cancer ; Gastrointestinal surgery ; Humans ; Kidneys ; Life Sciences & Biomedicine ; Methods ; Oncology ; Organs at Risk - radiation effects ; Patient outcomes ; Postoperative care ; Prognosis ; Radiation therapy ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Conformal - methods ; Radiotherapy, Intensity-Modulated - methods ; Science & Technology ; Stomach cancer ; Stomach Neoplasms - pathology ; Stomach Neoplasms - radiotherapy ; Stomach Neoplasms - surgery</subject><ispartof>Journal of cancer research and therapeutics, 2020-12, Vol.16 (Supplement), p.S133-S137</ispartof><rights>COPYRIGHT 2020 Medknow Publications and Media Pvt. Ltd.</rights><rights>2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>4</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000612861200023</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c474t-638a2f6a02ee2afbc03ea74fa875d7ebf517a19009a5526f4343bffed7a577f3</citedby><cites>FETCH-LOGICAL-c474t-638a2f6a02ee2afbc03ea74fa875d7ebf517a19009a5526f4343bffed7a577f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930,28253</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33380667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altinok, Pelin</creatorcontrib><creatorcontrib>Tekce, Ertugrul</creatorcontrib><creatorcontrib>Karakose, Fatih</creatorcontrib><creatorcontrib>Berk, Kemal</creatorcontrib><creatorcontrib>Kalafat, UEmmuehan</creatorcontrib><creatorcontrib>Kiziltan, Huriye Senay</creatorcontrib><creatorcontrib>Akgun, Zueleyha</creatorcontrib><creatorcontrib>Mayadagli, Alpaslan</creatorcontrib><title>Dosimetric comparison of modern radiotherapy techniques for gastric cancer after total gastrectomy</title><title>Journal of cancer research and therapeutics</title><addtitle>J CANCER RES THER</addtitle><addtitle>J Cancer Res Ther</addtitle><description>Purpose: The purpose of this study is to investigate the optimal radiotherapy technique for postoperative irradiation of gastric cancer treated with total gastrectomy. Materials and Methods: The database of ten patients was used for this study. Three-dimensional (3D) conformal radiotherapy, intensity-modulated therapy (IMRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) plans were created for each dataset. The prescription dose was 45 Gy in 25 fractions. Comparative analyses of the target volume coverage and the doses of organs at risk were performed. Results: HT was significantly provided more homogeneity. The best conformal plans were achieved with VMAT. Both kidneys were better preserved with HT and VMAT. HT significantly lowered the V13 of the left kidney and VMAT significantly lowered V20. However, the mean left kidney doses were not statistically different. The lowest liver V30 was obtained with VMAT but not with statistically different than IMRT and HT. Mean liver doses were statistically inferior with 3D. The worst spinal cord doses were seen with 3D. The integral dose of the body did not differ among the techniques. Conclusion: In comparison of the four techniques, 3D seems to be the most unsuitable method regarding sparing the normal tissues. According to availability, HT and VMAT should be primarily preferred. IMRT can also be used with carefully paying attention to the clinical condition of the patient.</description><subject>Care and treatment</subject><subject>Dosimetry</subject><subject>Gastrectomy</subject><subject>Gastrectomy - methods</subject><subject>Gastric cancer</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Life Sciences & Biomedicine</subject><subject>Methods</subject><subject>Oncology</subject><subject>Organs at Risk - radiation effects</subject><subject>Patient outcomes</subject><subject>Postoperative care</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Conformal - methods</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Science & Technology</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - radiotherapy</subject><subject>Stomach Neoplasms - surgery</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNktuLEzEUxgdR3Lr67pMM-CLIrLlO0sel3lkQpO_hTOakmzKT1CRl6X9vStf1Qh8k5ELy-05Ocr6meUnJlaCEv9vaVK6-rr6vjRTaUP2oWdDlUneCcv24WZCl4h0Vml00z3LeEiIVY_ppc8E516Tv1aIZ3sfsZyzJ29bGeQfJ5xja6No5jphCm2D0sdxigt2hLWhvg_-xx9y6mNoN5JMQgsXUgit1LLHAdDpCW-J8eN48cTBlfHE_Xzbrjx_Wq8_dzbdPX1bXN50VSpSu5xqY64EwRAZusIQjKOFAKzkqHJykCuiSkCVIyXonuOCDczgqkEo5ftm8OYXdpXjMsJjZZ4vTBAHjPhtWbxG9JpJW9PU_6DbuU6jJGSY563suJflNbWBC44OLJYE9BjXXvVBcEc2Osboz1AZD_bEpBnS-bv_FX53haxtx9vasgJwENsWcEzqzS36GdDCUmKMLzNEF5g8XVMmr-_fthxnHB8Gvslfg7Qm4wyG6bD3WAj5ghJCeMl17XTFeaf3_9MoXKD6GVdyHwn8CVDzPsA</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Altinok, Pelin</creator><creator>Tekce, Ertugrul</creator><creator>Karakose, Fatih</creator><creator>Berk, Kemal</creator><creator>Kalafat, UEmmuehan</creator><creator>Kiziltan, Huriye Senay</creator><creator>Akgun, Zueleyha</creator><creator>Mayadagli, Alpaslan</creator><general>Wolters Kluwer Medknow Publications</general><general>Medknow Publications and Media Pvt. 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Materials and Methods: The database of ten patients was used for this study. Three-dimensional (3D) conformal radiotherapy, intensity-modulated therapy (IMRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) plans were created for each dataset. The prescription dose was 45 Gy in 25 fractions. Comparative analyses of the target volume coverage and the doses of organs at risk were performed. Results: HT was significantly provided more homogeneity. The best conformal plans were achieved with VMAT. Both kidneys were better preserved with HT and VMAT. HT significantly lowered the V13 of the left kidney and VMAT significantly lowered V20. However, the mean left kidney doses were not statistically different. The lowest liver V30 was obtained with VMAT but not with statistically different than IMRT and HT. Mean liver doses were statistically inferior with 3D. The worst spinal cord doses were seen with 3D. The integral dose of the body did not differ among the techniques. Conclusion: In comparison of the four techniques, 3D seems to be the most unsuitable method regarding sparing the normal tissues. According to availability, HT and VMAT should be primarily preferred. IMRT can also be used with carefully paying attention to the clinical condition of the patient.</abstract><cop>MUMBAI</cop><pub>Wolters Kluwer Medknow Publications</pub><pmid>33380667</pmid><doi>10.4103/jcrt.JCRT_548_18</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Care and treatment Dosimetry Gastrectomy Gastrectomy - methods Gastric cancer Gastrointestinal surgery Humans Kidneys Life Sciences & Biomedicine Methods Oncology Organs at Risk - radiation effects Patient outcomes Postoperative care Prognosis Radiation therapy Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Conformal - methods Radiotherapy, Intensity-Modulated - methods Science & Technology Stomach cancer Stomach Neoplasms - pathology Stomach Neoplasms - radiotherapy Stomach Neoplasms - surgery |
| title | Dosimetric comparison of modern radiotherapy techniques for gastric cancer after total gastrectomy |
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