The CHEK2 Variant C.349AG Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor

It is well-recognised the strong contribution of genetic factors to prostate cancer (PrCa) susceptibility, thus genetic screening is critical for presymptomatic diagnosis and identification of individuals at high-risk. In this context, recurrent founder variants in cancer predisposing genes, by prov...

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Veröffentlicht in:	Cancers 2020-11, Vol.12 (11), p.1
Hauptverfasser:	Brandao, Andreia, Paulo, Paula, Maia, Sofia, Pinheiro, Manuela, Peixoto, Ana, Cardoso, Marta, Silva, Maria P, Santos, Catarina, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Wang, Ying, Pashayan, Nora, Batra, Jyotsna, Gronberg, Henrik, Neal, David E, Nordestgaard, Borge G, Tangen, Catherine M, Southey, Melissa C, Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A, Travis, Ruth C, Stanford, Janet L, Mucci, Lorelei A, West, Catharine M.L, Nielsen, Sune F, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sorensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Rosenstein, Barry S, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, de Ruyck, Kim, Razack, Azad, Newcomb, Lisa F, Lessel, Davor, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Roobol, Monique J, Teixeira, Manuel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic aspects Genetic variation Health aspects Prostate cancer Risk factors
Online-Zugang:	Volltext
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