Continuous administration of a p38[alpha] inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level

There is unmet need for effective stroke therapies. Numerous neuroprotection attempts for acute cerebral ischemia have failed and as a result there is growing interest in developing therapies to promote functional recovery through increasing synaptic plasticity. For this research study, we hypothesi...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0233073
Hauptverfasser:	Alam, John J, Krakovsky, Michael, Germann, Ursula, Levy, Aharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain-derived neurotrophic factor Chemical inhibitors Dosage and administration Drug therapy Physiological aspects Stroke
Online-Zugang:	Volltext
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