A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 channels via its sulfur-aromatic interactions with...

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Veröffentlicht in:eLife 2020-10, Vol.9
Hauptverfasser: Yeung, Priscilla S-W, Ing, Christopher E, Yamashita, Megumi, Pomès, Régis, Prakriya, Murali
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Sprache:eng
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