Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with BetaThalassemia Minor for Severe Aplastic Anemia
The first-line treatment for severe aplastic anemia (SAA) patients is hematopoietic stem cell transplantation (HSCT), with full-matched related donors considered the most suitable. We report a case of SAA in which the patient successfully underwent HSCT from a donor with [beta]-thalassemia minor. Th...
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| Veröffentlicht in: | Children (Basel) 2020-10, Vol.7 (10), p.1 |
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| creator | Jung, Mi Young Lim, Young Tae Lim, Hyunji Hah, Jeong Ok Lee, Jae Min |
| description | The first-line treatment for severe aplastic anemia (SAA) patients is hematopoietic stem cell transplantation (HSCT), with full-matched related donors considered the most suitable. We report a case of SAA in which the patient successfully underwent HSCT from a donor with [beta]-thalassemia minor. The patient in this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger brother with [beta]-thalassemia minor. A 7-year-old girl was referred to our facility following a 6-month history of easy bruising and pallor. Laboratory examinations showed pancytopenia and hypocellular bone marrow with cellularity of |
| doi_str_mv | 10.3390/children7100162 |
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We report a case of SAA in which the patient successfully underwent HSCT from a donor with [beta]-thalassemia minor. The patient in this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger brother with [beta]-thalassemia minor. A 7-year-old girl was referred to our facility following a 6-month history of easy bruising and pallor. Laboratory examinations showed pancytopenia and hypocellular bone marrow with cellularity of <5%. She was diagnosed with acquired SAA, and HLA typing of her family members was performed. Her younger brother was an HLA-matched sibling but had [beta]-thalassemia minor. Since his hemoglobin levels were maintained at 10-11 d/dL, he was considered a suitable HSCT donor. The conditioning regimen included fludarabine, cyclophosphamide, and anti-thymocyte globulin. The CD34+ and CD3+ cell counts were 6.6 * 10 (6)/kg and 0.48 * [10.sup.8]/kg, respectively. White blood cell engraftment was evident on day +11. Regimen-associated toxicities, such as anorexia and enteritis, were mild; no infections occurred, and no symptoms of acute graft-versus-host disease (GVHD) were observed. The 30-day follow-up bone marrow examination revealed normocellular marrow with 80%-90% cellularity. Acute or chronic GVHD has not been reported, and good performance status has been observed throughout the 5 years after HSCT. [beta]-thalassemia minor patients can be considered as bone marrow donors for SAA patients.</description><identifier>ISSN: 2227-9067</identifier><identifier>EISSN: 2227-9067</identifier><identifier>DOI: 10.3390/children7100162</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Aplastic anemia ; Care and treatment ; Case studies ; Patient outcomes ; Stem cells ; Thalassemia ; Transplantation</subject><ispartof>Children (Basel), 2020-10, Vol.7 (10), p.1</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Jung, Mi Young</creatorcontrib><creatorcontrib>Lim, Young Tae</creatorcontrib><creatorcontrib>Lim, Hyunji</creatorcontrib><creatorcontrib>Hah, Jeong Ok</creatorcontrib><creatorcontrib>Lee, Jae Min</creatorcontrib><title>Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with BetaThalassemia Minor for Severe Aplastic Anemia</title><title>Children (Basel)</title><description>The first-line treatment for severe aplastic anemia (SAA) patients is hematopoietic stem cell transplantation (HSCT), with full-matched related donors considered the most suitable. We report a case of SAA in which the patient successfully underwent HSCT from a donor with [beta]-thalassemia minor. The patient in this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger brother with [beta]-thalassemia minor. A 7-year-old girl was referred to our facility following a 6-month history of easy bruising and pallor. Laboratory examinations showed pancytopenia and hypocellular bone marrow with cellularity of <5%. She was diagnosed with acquired SAA, and HLA typing of her family members was performed. Her younger brother was an HLA-matched sibling but had [beta]-thalassemia minor. Since his hemoglobin levels were maintained at 10-11 d/dL, he was considered a suitable HSCT donor. The conditioning regimen included fludarabine, cyclophosphamide, and anti-thymocyte globulin. The CD34+ and CD3+ cell counts were 6.6 * 10 (6)/kg and 0.48 * [10.sup.8]/kg, respectively. White blood cell engraftment was evident on day +11. Regimen-associated toxicities, such as anorexia and enteritis, were mild; no infections occurred, and no symptoms of acute graft-versus-host disease (GVHD) were observed. The 30-day follow-up bone marrow examination revealed normocellular marrow with 80%-90% cellularity. Acute or chronic GVHD has not been reported, and good performance status has been observed throughout the 5 years after HSCT. [beta]-thalassemia minor patients can be considered as bone marrow donors for SAA patients.</description><subject>Aplastic anemia</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Patient outcomes</subject><subject>Stem cells</subject><subject>Thalassemia</subject><subject>Transplantation</subject><issn>2227-9067</issn><issn>2227-9067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNjT9PwzAUxC0EEhV0Zn0Sc8FxIKnHUEBdWEj26sl9Jkb-U9mv8An43iQSA2OH0510P90JcVPJu7rW8t6Mzu8zxbaSsmrUmVgopdqVlk17_i9fimUpn3JiavWo1u1C_PRHY6gUe_SwpYCcDskROwM9U4ANeQ9DxlgOHiMjuxTB5hQA4Q3ZjLSHd_LIkz-nmDJ8Ox7hiRiHET2WQsFNqJsrO6mnL8oE3TRX5pcuzsC1uLDoCy3__Ercvr4Mm-3qAz3tXLSJM5rgitl1zYPUWq-1rk-jfgGzGlpb</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Jung, Mi Young</creator><creator>Lim, Young Tae</creator><creator>Lim, Hyunji</creator><creator>Hah, Jeong Ok</creator><creator>Lee, Jae Min</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20201001</creationdate><title>Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with BetaThalassemia Minor for Severe Aplastic Anemia</title><author>Jung, Mi Young ; Lim, Young Tae ; Lim, Hyunji ; Hah, Jeong Ok ; Lee, Jae Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_infotracmisc_A6409998993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aplastic anemia</topic><topic>Care and treatment</topic><topic>Case studies</topic><topic>Patient outcomes</topic><topic>Stem cells</topic><topic>Thalassemia</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Mi Young</creatorcontrib><creatorcontrib>Lim, Young Tae</creatorcontrib><creatorcontrib>Lim, Hyunji</creatorcontrib><creatorcontrib>Hah, Jeong Ok</creatorcontrib><creatorcontrib>Lee, Jae Min</creatorcontrib><jtitle>Children (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Mi Young</au><au>Lim, Young Tae</au><au>Lim, Hyunji</au><au>Hah, Jeong Ok</au><au>Lee, Jae Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with BetaThalassemia Minor for Severe Aplastic Anemia</atitle><jtitle>Children (Basel)</jtitle><date>2020-10-01</date><risdate>2020</risdate><volume>7</volume><issue>10</issue><spage>1</spage><pages>1-</pages><issn>2227-9067</issn><eissn>2227-9067</eissn><abstract>The first-line treatment for severe aplastic anemia (SAA) patients is hematopoietic stem cell transplantation (HSCT), with full-matched related donors considered the most suitable. We report a case of SAA in which the patient successfully underwent HSCT from a donor with [beta]-thalassemia minor. The patient in this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger brother with [beta]-thalassemia minor. A 7-year-old girl was referred to our facility following a 6-month history of easy bruising and pallor. Laboratory examinations showed pancytopenia and hypocellular bone marrow with cellularity of <5%. She was diagnosed with acquired SAA, and HLA typing of her family members was performed. Her younger brother was an HLA-matched sibling but had [beta]-thalassemia minor. Since his hemoglobin levels were maintained at 10-11 d/dL, he was considered a suitable HSCT donor. The conditioning regimen included fludarabine, cyclophosphamide, and anti-thymocyte globulin. The CD34+ and CD3+ cell counts were 6.6 * 10 (6)/kg and 0.48 * [10.sup.8]/kg, respectively. White blood cell engraftment was evident on day +11. Regimen-associated toxicities, such as anorexia and enteritis, were mild; no infections occurred, and no symptoms of acute graft-versus-host disease (GVHD) were observed. The 30-day follow-up bone marrow examination revealed normocellular marrow with 80%-90% cellularity. Acute or chronic GVHD has not been reported, and good performance status has been observed throughout the 5 years after HSCT. [beta]-thalassemia minor patients can be considered as bone marrow donors for SAA patients.</abstract><pub>MDPI AG</pub><doi>10.3390/children7100162</doi></addata></record> |
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| ispartof | Children (Basel), 2020-10, Vol.7 (10), p.1 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Aplastic anemia Care and treatment Case studies Patient outcomes Stem cells Thalassemia Transplantation |
| title | Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor with BetaThalassemia Minor for Severe Aplastic Anemia |
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