The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer open access to scientific and medical research
Objective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer. Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our h...
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| Veröffentlicht in: | Cancer management and research 2020-09, Vol.12, p.8445 |
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| container_title | Cancer management and research |
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| creator | Chen, Xiaorao Han, Xiaoling Zhou, Honglian Liang, Yahai Huang, Zhong Li, Shujun Lin, Yanming Huang, Xiaobi Wu, Jiancong Su, Wenmei Lai, Zhennan Yang, Zhixiong |
| description | Objective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer. Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: [less than or equal to]40 y/o, 41-50 y/o, 51~60 y/o, 61~70 y/o, 71~ 80 y/o and >80 y/o. The clinical characteristics and prognosis of these patients were evaluated. Results: There were 1143 cases diagnosed in our hospital from 2012 to 2017. There were more non-smokers (p |
| doi_str_mv | 10.2147/CMAR.S240318 |
| format | Article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A639027355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A639027355</galeid><sourcerecordid>A639027355</sourcerecordid><originalsourceid>FETCH-LOGICAL-g675-c5f07df193ac72ef62a12269c919ed9ebb3ce866d91050df7d23f1207f15e0c13</originalsourceid><addsrcrecordid>eNptj81OwzAQhC0EEqVw4wFW4pzinyauj1H4lYqooPfKXa8To9RBcRAvwIMTCoce0B52tPpmRsvYpeAzKeb6unoqX2avcs6VWByxiRDaZEJJeXygT9lZSm-cF0ao-YR9rRuCqg0xoG2hamxvcaA-pCFgAhsdrPqujl0KCToPN8F76ikOUNYEKzuEUSf4DEMDy49YQ2UjUg_dO0WwiJQSDB0k_OGCD7iP3JHb1_WUyPbYnLMTb9tEF397ytZ3t-vqIVs-3z9W5TKrC51nmHuunRdGWdSSfCGtkLIwaIQhZ2i7VUiLonBG8Jw7r51UXkiuvciJo1BTdvUbW9uWNiH6bhi_3YWEm7JQhkut8nykZv9Q4zjaBewi-TDeDwzfsBdyiw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer open access to scientific and medical research</title><source>Taylor & Francis Open Access</source><source>DOVE Medical Press Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Chen, Xiaorao ; Han, Xiaoling ; Zhou, Honglian ; Liang, Yahai ; Huang, Zhong ; Li, Shujun ; Lin, Yanming ; Huang, Xiaobi ; Wu, Jiancong ; Su, Wenmei ; Lai, Zhennan ; Yang, Zhixiong</creator><creatorcontrib>Chen, Xiaorao ; Han, Xiaoling ; Zhou, Honglian ; Liang, Yahai ; Huang, Zhong ; Li, Shujun ; Lin, Yanming ; Huang, Xiaobi ; Wu, Jiancong ; Su, Wenmei ; Lai, Zhennan ; Yang, Zhixiong</creatorcontrib><description>Objective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer. Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: [less than or equal to]40 y/o, 41-50 y/o, 51~60 y/o, 61~70 y/o, 71~ 80 y/o and >80 y/o. The clinical characteristics and prognosis of these patients were evaluated. Results: There were 1143 cases diagnosed in our hospital from 2012 to 2017. There were more non-smokers (p<0.01), stage IV (p<0.01) and anaplastic lymphoma kinase (ALK) fusion (p<0.01) patients but less stage I patients in [less than or equal to]40 y/o group compared with other age groups. It seemed that older patients were more likely had co-exist driver gene mutations (p=0.04). There was no significant difference in overall survival (OS) among these 6 age groups. However, the age may be an independent prognostic factor compared with the patients in [less than or equal to]40 y/o group, the patients in >80 y/o group were associated with a higher mortality risk, while the patients in other groups had the similar mortality risk. Conclusion: There are some differences in clinical characteristics and prognosis among different age groups. The reasons behind the phenomenon are largely unclear. The age should be taken into account when we develop clinical trials. Keywords: age, lung cancer, clinical characteristics, clinical trials</description><identifier>ISSN: 1179-1322</identifier><identifier>EISSN: 1179-1322</identifier><identifier>DOI: 10.2147/CMAR.S240318</identifier><language>eng</language><publisher>Dove Medical Press Limited</publisher><subject>Cancer patients ; Cancer research ; China ; Gene mutation ; Lung cancer ; Lymphomas ; Mortality ; Prognosis</subject><ispartof>Cancer management and research, 2020-09, Vol.12, p.8445</ispartof><rights>COPYRIGHT 2020 Dove Medical Press Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Chen, Xiaorao</creatorcontrib><creatorcontrib>Han, Xiaoling</creatorcontrib><creatorcontrib>Zhou, Honglian</creatorcontrib><creatorcontrib>Liang, Yahai</creatorcontrib><creatorcontrib>Huang, Zhong</creatorcontrib><creatorcontrib>Li, Shujun</creatorcontrib><creatorcontrib>Lin, Yanming</creatorcontrib><creatorcontrib>Huang, Xiaobi</creatorcontrib><creatorcontrib>Wu, Jiancong</creatorcontrib><creatorcontrib>Su, Wenmei</creatorcontrib><creatorcontrib>Lai, Zhennan</creatorcontrib><creatorcontrib>Yang, Zhixiong</creatorcontrib><title>The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer open access to scientific and medical research</title><title>Cancer management and research</title><description>Objective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer. Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: [less than or equal to]40 y/o, 41-50 y/o, 51~60 y/o, 61~70 y/o, 71~ 80 y/o and >80 y/o. The clinical characteristics and prognosis of these patients were evaluated. Results: There were 1143 cases diagnosed in our hospital from 2012 to 2017. There were more non-smokers (p<0.01), stage IV (p<0.01) and anaplastic lymphoma kinase (ALK) fusion (p<0.01) patients but less stage I patients in [less than or equal to]40 y/o group compared with other age groups. It seemed that older patients were more likely had co-exist driver gene mutations (p=0.04). There was no significant difference in overall survival (OS) among these 6 age groups. However, the age may be an independent prognostic factor compared with the patients in [less than or equal to]40 y/o group, the patients in >80 y/o group were associated with a higher mortality risk, while the patients in other groups had the similar mortality risk. Conclusion: There are some differences in clinical characteristics and prognosis among different age groups. The reasons behind the phenomenon are largely unclear. The age should be taken into account when we develop clinical trials. Keywords: age, lung cancer, clinical characteristics, clinical trials</description><subject>Cancer patients</subject><subject>Cancer research</subject><subject>China</subject><subject>Gene mutation</subject><subject>Lung cancer</subject><subject>Lymphomas</subject><subject>Mortality</subject><subject>Prognosis</subject><issn>1179-1322</issn><issn>1179-1322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj81OwzAQhC0EEqVw4wFW4pzinyauj1H4lYqooPfKXa8To9RBcRAvwIMTCoce0B52tPpmRsvYpeAzKeb6unoqX2avcs6VWByxiRDaZEJJeXygT9lZSm-cF0ao-YR9rRuCqg0xoG2hamxvcaA-pCFgAhsdrPqujl0KCToPN8F76ikOUNYEKzuEUSf4DEMDy49YQ2UjUg_dO0WwiJQSDB0k_OGCD7iP3JHb1_WUyPbYnLMTb9tEF397ytZ3t-vqIVs-3z9W5TKrC51nmHuunRdGWdSSfCGtkLIwaIQhZ2i7VUiLonBG8Jw7r51UXkiuvciJo1BTdvUbW9uWNiH6bhi_3YWEm7JQhkut8nykZv9Q4zjaBewi-TDeDwzfsBdyiw</recordid><startdate>20200930</startdate><enddate>20200930</enddate><creator>Chen, Xiaorao</creator><creator>Han, Xiaoling</creator><creator>Zhou, Honglian</creator><creator>Liang, Yahai</creator><creator>Huang, Zhong</creator><creator>Li, Shujun</creator><creator>Lin, Yanming</creator><creator>Huang, Xiaobi</creator><creator>Wu, Jiancong</creator><creator>Su, Wenmei</creator><creator>Lai, Zhennan</creator><creator>Yang, Zhixiong</creator><general>Dove Medical Press Limited</general><scope/></search><sort><creationdate>20200930</creationdate><title>The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer open access to scientific and medical research</title><author>Chen, Xiaorao ; Han, Xiaoling ; Zhou, Honglian ; Liang, Yahai ; Huang, Zhong ; Li, Shujun ; Lin, Yanming ; Huang, Xiaobi ; Wu, Jiancong ; Su, Wenmei ; Lai, Zhennan ; Yang, Zhixiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g675-c5f07df193ac72ef62a12269c919ed9ebb3ce866d91050df7d23f1207f15e0c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer patients</topic><topic>Cancer research</topic><topic>China</topic><topic>Gene mutation</topic><topic>Lung cancer</topic><topic>Lymphomas</topic><topic>Mortality</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xiaorao</creatorcontrib><creatorcontrib>Han, Xiaoling</creatorcontrib><creatorcontrib>Zhou, Honglian</creatorcontrib><creatorcontrib>Liang, Yahai</creatorcontrib><creatorcontrib>Huang, Zhong</creatorcontrib><creatorcontrib>Li, Shujun</creatorcontrib><creatorcontrib>Lin, Yanming</creatorcontrib><creatorcontrib>Huang, Xiaobi</creatorcontrib><creatorcontrib>Wu, Jiancong</creatorcontrib><creatorcontrib>Su, Wenmei</creatorcontrib><creatorcontrib>Lai, Zhennan</creatorcontrib><creatorcontrib>Yang, Zhixiong</creatorcontrib><jtitle>Cancer management and research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xiaorao</au><au>Han, Xiaoling</au><au>Zhou, Honglian</au><au>Liang, Yahai</au><au>Huang, Zhong</au><au>Li, Shujun</au><au>Lin, Yanming</au><au>Huang, Xiaobi</au><au>Wu, Jiancong</au><au>Su, Wenmei</au><au>Lai, Zhennan</au><au>Yang, Zhixiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer open access to scientific and medical research</atitle><jtitle>Cancer management and research</jtitle><date>2020-09-30</date><risdate>2020</risdate><volume>12</volume><spage>8445</spage><pages>8445-</pages><issn>1179-1322</issn><eissn>1179-1322</eissn><abstract>Objective: Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on the relationship between age and clinical characteristics of lung cancer. Patients and Methods: We collected all the consecutive lung cancer cases from 2012 to 2017 in our hospital and divided them into 6 groups according to their ages: [less than or equal to]40 y/o, 41-50 y/o, 51~60 y/o, 61~70 y/o, 71~ 80 y/o and >80 y/o. The clinical characteristics and prognosis of these patients were evaluated. Results: There were 1143 cases diagnosed in our hospital from 2012 to 2017. There were more non-smokers (p<0.01), stage IV (p<0.01) and anaplastic lymphoma kinase (ALK) fusion (p<0.01) patients but less stage I patients in [less than or equal to]40 y/o group compared with other age groups. It seemed that older patients were more likely had co-exist driver gene mutations (p=0.04). There was no significant difference in overall survival (OS) among these 6 age groups. However, the age may be an independent prognostic factor compared with the patients in [less than or equal to]40 y/o group, the patients in >80 y/o group were associated with a higher mortality risk, while the patients in other groups had the similar mortality risk. Conclusion: There are some differences in clinical characteristics and prognosis among different age groups. The reasons behind the phenomenon are largely unclear. The age should be taken into account when we develop clinical trials. Keywords: age, lung cancer, clinical characteristics, clinical trials</abstract><pub>Dove Medical Press Limited</pub><doi>10.2147/CMAR.S240318</doi></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Cancer patients Cancer research China Gene mutation Lung cancer Lymphomas Mortality Prognosis |
| title | The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer open access to scientific and medical research |
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