Hypoxia-Inducible Factor-1[alpha] Activates the Transforming Growth Factor-[beta]/SMAD3 Pathway in Kidney Tubular Epithelial Cells

Background: Kidney injury, including chronic kidney disease and acute kidney injury, is a worldwide health problem. Hypoxia and transforming growth factor-[beta] (TGF-[beta]) are well-known factors that promote kidney injury. Hypoxia-inducible factor (HIF) and SMAD3 are their main downstream transcr...

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Veröffentlicht in:	American journal of nephrology 2016-10, Vol.44 (4), p.276
Hauptverfasser:	Kushida, Natsuki, Nomura, Seitaro, Mimura, Imari, Fujita, Takanori, Yamamoto, Shogo, Nangaku, Masaomi, Aburatani, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Epithelial cells Kidney diseases Physiological aspects Transcription factors Transforming growth factors
Online-Zugang:	Volltext
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