A perspective on potential antibody-dependent enhancement of SARS-CoV-2

Antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie antibody protection against any virus have a theoretical potential to amplify the infection or trigger harmful immunopathology. This possib...

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Veröffentlicht in:	Nature (London) 2020-08, Vol.584 (7821), p.353-363
Hauptverfasser:	Arvin, Ann M., Fink, Katja, Schmid, Michael A., Cathcart, Andrea, Spreafico, Roberto, Havenar-Daughton, Colin, Lanzavecchia, Antonio, Corti, Davide, Virgin, Herbert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/2153 631/250/590 631/326/596/4130 Analysis Animals Antibodies, Neutralizing - adverse effects Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Antibodies, Viral - adverse effects Antibodies, Viral - immunology Antibodies, Viral - therapeutic use Antibody-dependent cell cytotoxicity Antibody-Dependent Enhancement - immunology Betacoronavirus - immunology Betacoronavirus - pathogenicity Complications and side effects Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - virology COVID-19 COVID-19 Vaccines Dengue Virus - immunology Disease Models, Animal HEK293 Cells Humanities and Social Sciences Humans Immunoglobulin Fab Fragments - immunology Immunoglobulin Fc Fragments - immunology Immunoglobulin G - immunology Immunotherapy Macaca mulatta Mice Middle East Respiratory Syndrome Coronavirus - immunology multidisciplinary Orthomyxoviridae - immunology Pandemics Perspective Pneumonia, Viral - immunology Pneumonia, Viral - virology Rats SARS Virus - immunology SARS-CoV-2 Science Science (multidisciplinary) Viral Vaccines - adverse effects Viral Vaccines - immunology
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