Association of MUC1 5640GA and PSCA 5057CT polymorphisms with the risk of gastric cancer in Northern Iran
Gastric cancer is one of the four most common cancer that causing death worldwide. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was avaluating the associatio...
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| Veröffentlicht in: | BMC medical genetics 2020-07, Vol.21 (1) |
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| description | Gastric cancer is one of the four most common cancer that causing death worldwide. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was avaluating the association of rs4072037G > A polymorphism in MUC1 and rs2294008 C > T in PSCA gene with risk of gastric cancer in northern Iran. DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 peripheral blood samples from healthy individuals (sex matched) as controls. Two desired polymorphisms, 5640G > A and 5057C > T for MUC1 and PSCA genes were genotyped using PCR-RFLP method. The G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322-0.799, p = 0.003). A significant decreased risk of gastric cancer was observed in people with either AG vs. AA, AG + AA vs. GG and AA+GG vs. AG genotypes of MUC1 polymorphism (OR = 4.296, 95% CI: 1.190-15.517, p = 0.026), (OR = 3.726, 95% CI: 2.033-6.830, p = 0.0001) and (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001) respectively. Finally, there was no significant association between the PSCA 5057C > T polymorphism and risk of gastric cancer in all genetic models. |
| doi_str_mv | 10.1186/s12881-020-01085-z |
| format | Article |
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Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was avaluating the association of rs4072037G > A polymorphism in MUC1 and rs2294008 C > T in PSCA gene with risk of gastric cancer in northern Iran. DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 peripheral blood samples from healthy individuals (sex matched) as controls. Two desired polymorphisms, 5640G > A and 5057C > T for MUC1 and PSCA genes were genotyped using PCR-RFLP method. The G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322-0.799, p = 0.003). A significant decreased risk of gastric cancer was observed in people with either AG vs. AA, AG + AA vs. GG and AA+GG vs. AG genotypes of MUC1 polymorphism (OR = 4.296, 95% CI: 1.190-15.517, p = 0.026), (OR = 3.726, 95% CI: 2.033-6.830, p = 0.0001) and (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001) respectively. Finally, there was no significant association between the PSCA 5057C > T polymorphism and risk of gastric cancer in all genetic models.</description><identifier>ISSN: 1471-2350</identifier><identifier>EISSN: 1471-2350</identifier><identifier>DOI: 10.1186/s12881-020-01085-z</identifier><language>eng</language><publisher>BioMed Central Ltd</publisher><subject>Antigens ; Cancer ; Cancer research ; Cancer screening ; Development and progression ; EDTA ; Formaldehyde ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genomics ; Health aspects ; Mucins ; Risk factors ; Stem cells ; Stomach cancer</subject><ispartof>BMC medical genetics, 2020-07, Vol.21 (1)</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Alikhani, Reza</creatorcontrib><creatorcontrib>Taravati, Ali</creatorcontrib><creatorcontrib>Hashemi-Soteh, Mohammad Bagher</creatorcontrib><title>Association of MUC1 5640GA and PSCA 5057CT polymorphisms with the risk of gastric cancer in Northern Iran</title><title>BMC medical genetics</title><description>Gastric cancer is one of the four most common cancer that causing death worldwide. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was avaluating the association of rs4072037G > A polymorphism in MUC1 and rs2294008 C > T in PSCA gene with risk of gastric cancer in northern Iran. DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 peripheral blood samples from healthy individuals (sex matched) as controls. Two desired polymorphisms, 5640G > A and 5057C > T for MUC1 and PSCA genes were genotyped using PCR-RFLP method. The G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322-0.799, p = 0.003). A significant decreased risk of gastric cancer was observed in people with either AG vs. AA, AG + AA vs. GG and AA+GG vs. AG genotypes of MUC1 polymorphism (OR = 4.296, 95% CI: 1.190-15.517, p = 0.026), (OR = 3.726, 95% CI: 2.033-6.830, p = 0.0001) and (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001) respectively. Finally, there was no significant association between the PSCA 5057C > T polymorphism and risk of gastric cancer in all genetic models.</description><subject>Antigens</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer screening</subject><subject>Development and progression</subject><subject>EDTA</subject><subject>Formaldehyde</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Mucins</subject><subject>Risk factors</subject><subject>Stem cells</subject><subject>Stomach cancer</subject><issn>1471-2350</issn><issn>1471-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNptjk1PwzAMhiMEEmPwBzhF4sShI26aJjtWFYxJ40NsO09emnaBNUFJER-_niI4bBLywdar57FNyDmwEYDKryKkSkHCUpYwYEokXwdkAJmEJOWCHe7Mx-QkxmfGQCrOB8QWMXptsbPeUV_Tu2UJVOQZmxQUXUUf52VBBROyXNBXv_1sfXjd2NhG-m67De02hgYbX37UBmMXrKYanTaBWkfvfeiB4Og0oDslRzVuozn760OyvLlelLfJ7GEyLYtZ0kD_emJQVEyiShk3qBjWWqd6LDCXkufrDCATIs-lUutKyWqthMJUGwk4Rhwrw_iQXPzubXBrVtbVvguoWxv1qsg5qDHvz_TU6B-qr8q0Vntnatvne8LlntAznfnoGnyLcTWdP-2y31UsdJE</recordid><startdate>20200713</startdate><enddate>20200713</enddate><creator>Alikhani, Reza</creator><creator>Taravati, Ali</creator><creator>Hashemi-Soteh, Mohammad Bagher</creator><general>BioMed Central Ltd</general><scope>ISR</scope></search><sort><creationdate>20200713</creationdate><title>Association of MUC1 5640GA and PSCA 5057CT polymorphisms with the risk of gastric cancer in Northern Iran</title><author>Alikhani, Reza ; Taravati, Ali ; Hashemi-Soteh, Mohammad Bagher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1010-ea5d07a8203ea80afcc2c95a67736b41145566788bd87db858a2ce71a9aa98e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigens</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cancer screening</topic><topic>Development and progression</topic><topic>EDTA</topic><topic>Formaldehyde</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Mucins</topic><topic>Risk factors</topic><topic>Stem cells</topic><topic>Stomach cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alikhani, Reza</creatorcontrib><creatorcontrib>Taravati, Ali</creatorcontrib><creatorcontrib>Hashemi-Soteh, Mohammad Bagher</creatorcontrib><collection>Gale In Context: Science</collection><jtitle>BMC medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alikhani, Reza</au><au>Taravati, Ali</au><au>Hashemi-Soteh, Mohammad Bagher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of MUC1 5640GA and PSCA 5057CT polymorphisms with the risk of gastric cancer in Northern Iran</atitle><jtitle>BMC medical genetics</jtitle><date>2020-07-13</date><risdate>2020</risdate><volume>21</volume><issue>1</issue><issn>1471-2350</issn><eissn>1471-2350</eissn><abstract>Gastric cancer is one of the four most common cancer that causing death worldwide. Genome-Wide Association Studies (GWAS) have shown that genetic diversities MUC1 (Mucin 1) and PSCA (Prostate Stem Cell Antigen) genes are involved in gastric cancer. The aim of this study was avaluating the association of rs4072037G > A polymorphism in MUC1 and rs2294008 C > T in PSCA gene with risk of gastric cancer in northern Iran. DNA was extracted from 99 formalin fixed paraffin-embedded (FFPE) tissue samples of gastric cancer and 96 peripheral blood samples from healthy individuals (sex matched) as controls. Two desired polymorphisms, 5640G > A and 5057C > T for MUC1 and PSCA genes were genotyped using PCR-RFLP method. The G allele at rs4072037 of MUC1 gene was associated with a significant decreased gastric cancer risk (OR = 0.507, 95% CI: 0.322-0.799, p = 0.003). A significant decreased risk of gastric cancer was observed in people with either AG vs. AA, AG + AA vs. GG and AA+GG vs. AG genotypes of MUC1 polymorphism (OR = 4.296, 95% CI: 1.190-15.517, p = 0.026), (OR = 3.726, 95% CI: 2.033-6.830, p = 0.0001) and (OR = 0.223, 95% CI: 0.120-0.413, p = 0.0001) respectively. Finally, there was no significant association between the PSCA 5057C > T polymorphism and risk of gastric cancer in all genetic models.</abstract><pub>BioMed Central Ltd</pub><doi>10.1186/s12881-020-01085-z</doi></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Antigens Cancer Cancer research Cancer screening Development and progression EDTA Formaldehyde Genes Genetic aspects Genetic polymorphisms Genomics Health aspects Mucins Risk factors Stem cells Stomach cancer |
| title | Association of MUC1 5640GA and PSCA 5057CT polymorphisms with the risk of gastric cancer in Northern Iran |
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