Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data

Background: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. Methods: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled...

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Veröffentlicht in:	American journal of nephrology 2018-11, Vol.48 (4), p.260-268
Hauptverfasser:	Macdougall, Iain C., White, Claire, Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Kalra, Philip A., McMurray, John J.V., Murray, Heather, Steenkamp, Retha, Tomson, Charles R.V., Wheeler, David C., Winearls, Christopher G., Ford, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Aged Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - drug therapy Anemia, Iron-Deficiency - etiology Care and treatment Chronic kidney failure Dietary supplements Dosage and administration Dose-Response Relationship, Drug Female Ferric Oxide, Saccharated - administration & dosage Ferric Oxide, Saccharated - adverse effects Ferritins - blood Follow-Up Studies Health aspects Hematinics - administration & dosage Hematinics - adverse effects Hemodialysis patients Humans Intravenous therapy Iron in the body Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Methods Middle Aged Original Report: Patient-Oriented, Translational Research Prospective Studies Renal Dialysis - adverse effects Thrombosis - chemically induced Thrombosis - epidemiology Treatment Outcome
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