Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus
Objectives To evaluate cancer treatment–related toxicities in young head and neck cancer (HNC) patients. Material and methods A total of 44 patients were included in the present retrospective cohort study, which was designed to access oral toxicities of cancer treatment in young ( 58 years of age, G...
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| Veröffentlicht in: | Supportive care in cancer 2020-09, Vol.28 (9), p.4345-4352 |
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| creator | Morais-Faria, Karina Palmier, Natalia Rangel de Lima Correia, Jaqueline de Castro Júnior, Gilberto Dias, Reinaldo Brito da Graça Pinto, Henrique Lopes, Marcio Ajudarte Ribeiro, Ana Carolina Prado Brandão, Thaís Bianca Santos-Silva, Alan Roger |
| description | Objectives
To evaluate cancer treatment–related toxicities in young head and neck cancer (HNC) patients.
Material and methods
A total of 44 patients were included in the present retrospective cohort study, which was designed to access oral toxicities of cancer treatment in young ( 58 years of age, Group II,
n
= 22) HNC patients with similar tumor stage and treatment protocols. Oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis were assessed during days 7th, 21st, and 35th of head and neck radiotherapy (HNRT) according to previously validated scales (World Health Organization criteria and the National Cancer Institute and Common Terminology Criteria for Adverse Events version 4.0).
Results
Patients from both groups showed high incidence and severity of oral toxicities by the end of the HNRT with OM (81.9% (Group I); 63.6% (Group II)) and xerostomia (72.6% (Group I); 77.2% (Group II)) being the most prevalent toxicities. No differences regarding xerostomia, dysphagia, dysgeusia, and radiodermatitis incidences or severity could be observed between groups. However, higher incidences and severity of OM at 21st and 35th fractions (odds ratio = 2.22 and 5.71, respectively) and trismus at 21st and 35th fractions (odds ratio = 6.17 and 14.5, respectively) were observed throughout the treatment in young patients when compared to older patients (
p
|
| doi_str_mv | 10.1007/s00520-019-05241-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_gale_infotracmisc_A630447329</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A630447329</galeid><sourcerecordid>A630447329</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-b5e3c88c2ed553f0e815f1d7985693cd47df555cea3ba1b132df7b299bdb8b13</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lr9Ay4k4EaQqfmcmSzLxS8ouOnGVcgkZ65pZ5JrMqP133vaW1sUESeLScLzvhzyEPKcsxPOWPemMqYFaxg3DW4Ub64ekA1XUjadlOYh2TCDl0pqfUSe1HrBGO86LR6TI8kNF1KbDRk-5zXt6BdwgboUaAJ_Sb1LHgrduyVCWip1BahbaEy-gKsQaIn1kuaRBvgGU95HbMjFTXRefa5xifWma0FsXutT8mh0U4Vnt_9jcv7u7fn2Q3P26f3H7elZ45USSzNokL7vvYCgtRwZ9FyPPHSm162RPqgujFprD04Ojg9cijB2gzBmCEOPx2Py6lC7L_nrCnWxc6wepsklyGu1QkrVGvxaRF_-gV7ktSQczgolWtmaVvX31M5NYGMa81Kcvy61p61kSnVSGKRO_kLhCjBHnxOMEe9_C4hDwJdca4HR7kucXflhObPXXu3Bq0Wv9sarvcLQi9uJ12GGcBf5JRKB_gB8hyGP1aM4D3cYw0bNtegM7lS7jQuqzWmL7heMvv7_KNLyQFck0g7K_dv9Y_6fVdfNww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2426369648</pqid></control><display><type>article</type><title>Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus</title><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Morais-Faria, Karina ; Palmier, Natalia Rangel ; de Lima Correia, Jaqueline ; de Castro Júnior, Gilberto ; Dias, Reinaldo Brito ; da Graça Pinto, Henrique ; Lopes, Marcio Ajudarte ; Ribeiro, Ana Carolina Prado ; Brandão, Thaís Bianca ; Santos-Silva, Alan Roger</creator><creatorcontrib>Morais-Faria, Karina ; Palmier, Natalia Rangel ; de Lima Correia, Jaqueline ; de Castro Júnior, Gilberto ; Dias, Reinaldo Brito ; da Graça Pinto, Henrique ; Lopes, Marcio Ajudarte ; Ribeiro, Ana Carolina Prado ; Brandão, Thaís Bianca ; Santos-Silva, Alan Roger</creatorcontrib><description>Objectives
To evaluate cancer treatment–related toxicities in young head and neck cancer (HNC) patients.
Material and methods
A total of 44 patients were included in the present retrospective cohort study, which was designed to access oral toxicities of cancer treatment in young (< 45 years of age, Group I,
n
= 22) and old (> 58 years of age, Group II,
n
= 22) HNC patients with similar tumor stage and treatment protocols. Oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis were assessed during days 7th, 21st, and 35th of head and neck radiotherapy (HNRT) according to previously validated scales (World Health Organization criteria and the National Cancer Institute and Common Terminology Criteria for Adverse Events version 4.0).
Results
Patients from both groups showed high incidence and severity of oral toxicities by the end of the HNRT with OM (81.9% (Group I); 63.6% (Group II)) and xerostomia (72.6% (Group I); 77.2% (Group II)) being the most prevalent toxicities. No differences regarding xerostomia, dysphagia, dysgeusia, and radiodermatitis incidences or severity could be observed between groups. However, higher incidences and severity of OM at 21st and 35th fractions (odds ratio = 2.22 and 5.71, respectively) and trismus at 21st and 35th fractions (odds ratio = 6.17 and 14.5, respectively) were observed throughout the treatment in young patients when compared to older patients (
p
< 0.01 and
p
< 0.05, respectively).
Conclusion
Young HNC patients are more affected by cancer treatment–related OM and trismus despite the similarities in clinical staging and treatment protocols with elderly patients.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-019-05241-x</identifier><identifier>PMID: 31912359</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Cancer patients ; Cancer therapies ; Deglutition disorders ; Dysphagia ; Head & neck cancer ; Head and neck cancer ; Health Care Sciences & Services ; Life Sciences & Biomedicine ; Medical colleges ; Medicine ; Medicine & Public Health ; Mucositis ; Nursing ; Nursing Research ; Oncology ; Oncology, Experimental ; Original Article ; Pain Medicine ; Palliative care ; Radiation therapy ; Rehabilitation ; Rehabilitation Medicine ; Science & Technology ; Stomatitis ; Taste disorders ; World health</subject><ispartof>Supportive care in cancer, 2020-09, Vol.28 (9), p.4345-4352</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000551527900046</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c442t-b5e3c88c2ed553f0e815f1d7985693cd47df555cea3ba1b132df7b299bdb8b13</citedby><cites>FETCH-LOGICAL-c442t-b5e3c88c2ed553f0e815f1d7985693cd47df555cea3ba1b132df7b299bdb8b13</cites><orcidid>0000-0003-2040-6617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-019-05241-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-019-05241-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,28255,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31912359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morais-Faria, Karina</creatorcontrib><creatorcontrib>Palmier, Natalia Rangel</creatorcontrib><creatorcontrib>de Lima Correia, Jaqueline</creatorcontrib><creatorcontrib>de Castro Júnior, Gilberto</creatorcontrib><creatorcontrib>Dias, Reinaldo Brito</creatorcontrib><creatorcontrib>da Graça Pinto, Henrique</creatorcontrib><creatorcontrib>Lopes, Marcio Ajudarte</creatorcontrib><creatorcontrib>Ribeiro, Ana Carolina Prado</creatorcontrib><creatorcontrib>Brandão, Thaís Bianca</creatorcontrib><creatorcontrib>Santos-Silva, Alan Roger</creatorcontrib><title>Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>SUPPORT CARE CANCER</addtitle><addtitle>Support Care Cancer</addtitle><description>Objectives
To evaluate cancer treatment–related toxicities in young head and neck cancer (HNC) patients.
Material and methods
A total of 44 patients were included in the present retrospective cohort study, which was designed to access oral toxicities of cancer treatment in young (< 45 years of age, Group I,
n
= 22) and old (> 58 years of age, Group II,
n
= 22) HNC patients with similar tumor stage and treatment protocols. Oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis were assessed during days 7th, 21st, and 35th of head and neck radiotherapy (HNRT) according to previously validated scales (World Health Organization criteria and the National Cancer Institute and Common Terminology Criteria for Adverse Events version 4.0).
Results
Patients from both groups showed high incidence and severity of oral toxicities by the end of the HNRT with OM (81.9% (Group I); 63.6% (Group II)) and xerostomia (72.6% (Group I); 77.2% (Group II)) being the most prevalent toxicities. No differences regarding xerostomia, dysphagia, dysgeusia, and radiodermatitis incidences or severity could be observed between groups. However, higher incidences and severity of OM at 21st and 35th fractions (odds ratio = 2.22 and 5.71, respectively) and trismus at 21st and 35th fractions (odds ratio = 6.17 and 14.5, respectively) were observed throughout the treatment in young patients when compared to older patients (
p
< 0.01 and
p
< 0.05, respectively).
Conclusion
Young HNC patients are more affected by cancer treatment–related OM and trismus despite the similarities in clinical staging and treatment protocols with elderly patients.</description><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Deglutition disorders</subject><subject>Dysphagia</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Health Care Sciences & Services</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mucositis</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Palliative care</subject><subject>Radiation therapy</subject><subject>Rehabilitation</subject><subject>Rehabilitation Medicine</subject><subject>Science & Technology</subject><subject>Stomatitis</subject><subject>Taste disorders</subject><subject>World health</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9Ay4k4EaQqfmcmSzLxS8ouOnGVcgkZ65pZ5JrMqP133vaW1sUESeLScLzvhzyEPKcsxPOWPemMqYFaxg3DW4Ub64ekA1XUjadlOYh2TCDl0pqfUSe1HrBGO86LR6TI8kNF1KbDRk-5zXt6BdwgboUaAJ_Sb1LHgrduyVCWip1BahbaEy-gKsQaIn1kuaRBvgGU95HbMjFTXRefa5xifWma0FsXutT8mh0U4Vnt_9jcv7u7fn2Q3P26f3H7elZ45USSzNokL7vvYCgtRwZ9FyPPHSm162RPqgujFprD04Ojg9cijB2gzBmCEOPx2Py6lC7L_nrCnWxc6wepsklyGu1QkrVGvxaRF_-gV7ktSQczgolWtmaVvX31M5NYGMa81Kcvy61p61kSnVSGKRO_kLhCjBHnxOMEe9_C4hDwJdca4HR7kucXflhObPXXu3Bq0Wv9sarvcLQi9uJ12GGcBf5JRKB_gB8hyGP1aM4D3cYw0bNtegM7lS7jQuqzWmL7heMvv7_KNLyQFck0g7K_dv9Y_6fVdfNww</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Morais-Faria, Karina</creator><creator>Palmier, Natalia Rangel</creator><creator>de Lima Correia, Jaqueline</creator><creator>de Castro Júnior, Gilberto</creator><creator>Dias, Reinaldo Brito</creator><creator>da Graça Pinto, Henrique</creator><creator>Lopes, Marcio Ajudarte</creator><creator>Ribeiro, Ana Carolina Prado</creator><creator>Brandão, Thaís Bianca</creator><creator>Santos-Silva, Alan Roger</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2040-6617</orcidid></search><sort><creationdate>20200901</creationdate><title>Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus</title><author>Morais-Faria, Karina ; Palmier, Natalia Rangel ; de Lima Correia, Jaqueline ; de Castro Júnior, Gilberto ; Dias, Reinaldo Brito ; da Graça Pinto, Henrique ; Lopes, Marcio Ajudarte ; Ribeiro, Ana Carolina Prado ; Brandão, Thaís Bianca ; Santos-Silva, Alan Roger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b5e3c88c2ed553f0e815f1d7985693cd47df555cea3ba1b132df7b299bdb8b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Deglutition disorders</topic><topic>Dysphagia</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Health Care Sciences & Services</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mucositis</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Palliative care</topic><topic>Radiation therapy</topic><topic>Rehabilitation</topic><topic>Rehabilitation Medicine</topic><topic>Science & Technology</topic><topic>Stomatitis</topic><topic>Taste disorders</topic><topic>World health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morais-Faria, Karina</creatorcontrib><creatorcontrib>Palmier, Natalia Rangel</creatorcontrib><creatorcontrib>de Lima Correia, Jaqueline</creatorcontrib><creatorcontrib>de Castro Júnior, Gilberto</creatorcontrib><creatorcontrib>Dias, Reinaldo Brito</creatorcontrib><creatorcontrib>da Graça Pinto, Henrique</creatorcontrib><creatorcontrib>Lopes, Marcio Ajudarte</creatorcontrib><creatorcontrib>Ribeiro, Ana Carolina Prado</creatorcontrib><creatorcontrib>Brandão, Thaís Bianca</creatorcontrib><creatorcontrib>Santos-Silva, Alan Roger</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morais-Faria, Karina</au><au>Palmier, Natalia Rangel</au><au>de Lima Correia, Jaqueline</au><au>de Castro Júnior, Gilberto</au><au>Dias, Reinaldo Brito</au><au>da Graça Pinto, Henrique</au><au>Lopes, Marcio Ajudarte</au><au>Ribeiro, Ana Carolina Prado</au><au>Brandão, Thaís Bianca</au><au>Santos-Silva, Alan Roger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><stitle>SUPPORT CARE CANCER</stitle><addtitle>Support Care Cancer</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>28</volume><issue>9</issue><spage>4345</spage><epage>4352</epage><pages>4345-4352</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Objectives
To evaluate cancer treatment–related toxicities in young head and neck cancer (HNC) patients.
Material and methods
A total of 44 patients were included in the present retrospective cohort study, which was designed to access oral toxicities of cancer treatment in young (< 45 years of age, Group I,
n
= 22) and old (> 58 years of age, Group II,
n
= 22) HNC patients with similar tumor stage and treatment protocols. Oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis were assessed during days 7th, 21st, and 35th of head and neck radiotherapy (HNRT) according to previously validated scales (World Health Organization criteria and the National Cancer Institute and Common Terminology Criteria for Adverse Events version 4.0).
Results
Patients from both groups showed high incidence and severity of oral toxicities by the end of the HNRT with OM (81.9% (Group I); 63.6% (Group II)) and xerostomia (72.6% (Group I); 77.2% (Group II)) being the most prevalent toxicities. No differences regarding xerostomia, dysphagia, dysgeusia, and radiodermatitis incidences or severity could be observed between groups. However, higher incidences and severity of OM at 21st and 35th fractions (odds ratio = 2.22 and 5.71, respectively) and trismus at 21st and 35th fractions (odds ratio = 6.17 and 14.5, respectively) were observed throughout the treatment in young patients when compared to older patients (
p
< 0.01 and
p
< 0.05, respectively).
Conclusion
Young HNC patients are more affected by cancer treatment–related OM and trismus despite the similarities in clinical staging and treatment protocols with elderly patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31912359</pmid><doi>10.1007/s00520-019-05241-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2040-6617</orcidid></addata></record> |
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| ispartof | Supportive care in cancer, 2020-09, Vol.28 (9), p.4345-4352 |
| issn | 0941-4355 1433-7339 |
| language | eng |
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| source | SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Cancer Cancer patients Cancer therapies Deglutition disorders Dysphagia Head & neck cancer Head and neck cancer Health Care Sciences & Services Life Sciences & Biomedicine Medical colleges Medicine Medicine & Public Health Mucositis Nursing Nursing Research Oncology Oncology, Experimental Original Article Pain Medicine Palliative care Radiation therapy Rehabilitation Rehabilitation Medicine Science & Technology Stomatitis Taste disorders World health |
| title | Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus |
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