Experimental Study of the Biodistribution of New Bone-Seeking Compounds Based on Phosphonic Acids and Gallium-68

We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid ( 68 Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) ( 68 Ga-DTPMP) in intact Wistar rats. It was shown that 68 Ga-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/m...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2020-04, Vol.168 (6), p.777-780
Hauptverfasser:	Tishchenko, V. K., Petriev, V. M., Mikhailovskaya, A. A., Stepchenkova, E. D., Timoshenko, V. Yu, Postnov, A. A., Zavestovskaya, I. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Biomedical and Life Sciences Biomedicine Cell Biology Etidronic Acid - blood Etidronic Acid - pharmacokinetics Female Femur - diagnostic imaging Gallium Radioisotopes - blood Gallium Radioisotopes - pharmacokinetics Internal Medicine Laboratory Medicine Metastasis Oncology Organ Specificity Pathology Phosphonates Phosphorous Acids - blood Phosphorous Acids - pharmacokinetics Positron-Emission Tomography - methods Prostate cancer Radiopharmaceuticals - blood Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Tissue Distribution
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