Divergent Cl.sup.- and H.sup.+ pathways underlie transport coupling and gating in CLC exchangers and channels

The CLC family comprises H.sup.+-coupled exchangers and Cl.sup.- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrates through partially congruent pathways. H...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	eLife 2020-04, Vol.9
Hauptverfasser:	Leisle, Lilia, Xu, Yanyan, Fortea, Eva, Lee, Sangyun, Galpin, Jason D, Vien, Malvin, Ahern, Christopher A, Accardi, Alessio, Bernèche, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Chemical plants Membrane proteins Phenylalanine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!