Mutational signature in colorectal cancer caused by genotoxic pks.sup.+E. coli

Various species of the intestinal microbiota have been associated with the development of colorectal cancer.sup.1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a se...

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Veröffentlicht in:	Nature (London) 2020-04, Vol.580 (7802), p.269
Hauptverfasser:	Pleguezuelos-Manzano, Cayetano, Puschhof, Jens, Rosendahl Huber, Axel, van Hoeck, Arne, Wood, Henry M, Nomburg, Jason, Gurjao, Carino
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Causes of Chromosome abnormalities Colorectal cancer Escherichia coli Genetic aspects Genetic toxicology Methods
Online-Zugang:	Volltext
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