Synthesis and Antidepressant Activity of 8-Amino-Substituted 1-Butyl-3-Methylxanthines Containing a Thietane Ring
A series of 8-amino-substituted 1-butyl-3-methylxanthines containing a thietane ring were obtained in 47 – 96% yields by reacting 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-1-butyl-3-methylxanthines with piperidine and morpholine. Reaction of 8-amino-substituted 1-...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2020-02, Vol.53 (11), p.1009-1012 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Shabalina, Yu. V. Khaliullin, F. A. Nikitina, I. L. Miftakhova, A. F. Sharafutdinov, R. M. |
| description | A series of 8-amino-substituted 1-butyl-3-methylxanthines containing a thietane ring were obtained in 47 – 96% yields by reacting 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-1-butyl-3-methylxanthines with piperidine and morpholine. Reaction of 8-amino-substituted 1-butyl-3-methyl-7-(1,1-dioxothietanyl-3)xanthines with sodium ethoxide synthesized 8-amino-substituted 1-butyl-3-methylxanthines in 85 – 98% yields. The structures of the compounds were confirmed by IR and PMR spectroscopy. The synthesized compounds exhibited antidepressant activity. |
| doi_str_mv | 10.1007/s11094-020-02114-0 |
| format | Article |
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The synthesized compounds exhibited antidepressant activity.</description><subject>Antidepressants</subject><subject>Medicine</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Xanthine</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kdtKAzEQhoMoWA8v4FXA6-jMpts1l2vxBBXBA3gXsruTbkqbrZtU3Lc3Wm8EkWGYA_83MPyMnSCcIUBxHhBBjQVkkBIxdTtshHkhhQKJu2wEoFBgDq_77CCEBUDCZDZib0-Djy0FF7jxDS99dA2tewrB-MjLOrp3FwfeWX4hypXznXjaVCG6uInUcBSXmzgshRT3FNth-ZGg1nkKfNr5aJx3fs4Nf24dReOJP6b5iO1Zswx0_FMP2cv11fP0Vswebu6m5UzUMr-IIkNlx6omklVFisDmGRZUV4UiaSeKcjsBkzdVUYBtsDLGSlSUigWDVWHlITvd3p2bJWnnbRd7U69cqHU5QZWNMcdxUp39oUrR0MrVnSfr0v4XkG2Buu9C6Mnqde9Wph80gv7yQm-90MkL_e2FhgTJLRSS2M-p14tu0_v0_n_UJw2Pjcc</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Shabalina, Yu. 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Reaction of 8-amino-substituted 1-butyl-3-methyl-7-(1,1-dioxothietanyl-3)xanthines with sodium ethoxide synthesized 8-amino-substituted 1-butyl-3-methylxanthines in 85 – 98% yields. The structures of the compounds were confirmed by IR and PMR spectroscopy. The synthesized compounds exhibited antidepressant activity.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-020-02114-0</doi><tpages>4</tpages></addata></record> |
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| subjects | Antidepressants Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Xanthine |
| title | Synthesis and Antidepressant Activity of 8-Amino-Substituted 1-Butyl-3-Methylxanthines Containing a Thietane Ring |
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