Long-range single-molecule mapping of chromatin accessibility in eukaryotes

Mapping open chromatin regions has emerged as a widely used tool for identifying active regulatory elements in eukaryotes. However, existing approaches, limited by reliance on DNA fragmentation and short-read sequencing, cannot provide information about large-scale chromatin states or reveal coordin...

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Veröffentlicht in:	Nature methods 2020-03, Vol.17 (3), p.319-327
Hauptverfasser:	Shipony, Zohar, Marinov, Georgi K., Swaffer, Matthew P., Sinnott-Armstrong, Nicholas A., Skotheim, Jan M., Kundaje, Anshul, Greenleaf, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2210/2211 631/1647/2210/2213 631/208/176 Accessibility Adenosine - analogs & derivatives Adenosine - chemistry Biochemical Research Methods Biochemistry & Molecular Biology Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Cell Line Chromatin Chromatin - chemistry Chromatin Immunoprecipitation Chromosome mapping CpG Islands Deoxyribonucleic acid DIABLO protein DNA DNA Fragmentation DNA Methylation DNA sequencing Eukaryotes Fibers Gene mapping Genetic aspects High-Throughput Nucleotide Sequencing Humans Life Sciences Life Sciences & Biomedicine Mapping Methods Methylation Methyltransferase Methyltransferases - genetics N6-methyladenosine Nucleosomes Nucleosomes - chemistry Nucleotide sequence Porosity Promoter Regions, Genetic Properties Protein Binding Proteomics Regulatory sequences Saccharomyces cerevisiae - chemistry Science & Technology
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