Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis

Aurora B is a serine/threonine kinase that has been implicated in regulating cell proliferation in distinct cancers, including breast cancer. Here we show that Aurora B expression is elevated in basal-like breast cancer (BLBC) compared with other breast cancer subtypes. This high level of expression...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2020-03, Vol.39 (12), p.2550-2567
Hauptverfasser:	Zhang, Jianchao, Lin, Xinxin, Wu, Liufeng, Huang, Jia-Jia, Jiang, Wen-Qi, Kipps, Thomas J., Zhang, Suping
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/105 13/109 13/44 13/51 13/89 13/95 14/34 38/22 59 59/5 631/67/395 64 692/53/2423 82 AKT protein Animals Apoptosis Aurora B protein Aurora Kinase B - antagonists & inhibitors Aurora Kinase B - metabolism Biochemistry & Molecular Biology Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal - metabolism Carcinoma, Ductal - pathology Care and treatment Cell Biology Cell Line, Tumor Cell proliferation Complications and side effects Down-Regulation Enzyme inhibitors Epithelial-Mesenchymal Transition Female Gene expression Genetic aspects Genetics & Heredity Glycogen Synthase Kinase 3 beta - metabolism Health aspects Human Genetics Humans Internal Medicine Kinases Life Sciences & Biomedicine Lung Neoplasms - secondary Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Inbred NOD Neoplasm Invasiveness Neoplasm Metastasis Oct-4 protein Octamer Transcription Factor-3 - metabolism Oncology Organophosphates - pharmacology Phosphorylation Phosphotransferases Protein Kinase Inhibitors - pharmacology Protein Stability Protein-serine/threonine kinase Quinazolines - pharmacology Risk factors Science & Technology Signal Transduction Snail Family Transcription Factors - metabolism Triple Negative Breast Neoplasms - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!