Modulation of the Erwinia ligand-gated ion channel and the 5-HT.sub.3 receptor via a common vestibule site

Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of ligand binding to channel opening. In this study, we d...

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Veröffentlicht in:	eLife 2020-01, Vol.9
Hauptverfasser:	Brams, Marijke, Govaerts, Cedric, Kambara, Kumiko, Price, Kerry L, Spurny, Radovan, Gharpure, Anant, Pardon, Els, Evans, Genevieve L, Bertrand, Daniel, Lummis, Sarah CR, Hibbs, Ryan E, Steyaert, Jan, Ulens, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Crystal structure Flurazepam Ion channels
Online-Zugang:	Volltext
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